登録情報 データベース : PDB / ID : 7lzd 構造の表示 ダウンロードとリンクタイトル Crystal Structure of SETD2 bound to Compound 35 要素Histone-lysine N-methyltransferase SETD2 詳細 キーワード TRANSFERASE機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
mesoderm morphogenesis / coronary vasculature morphogenesis / morphogenesis of a branching structure / peptidyl-lysine trimethylation / cell migration involved in vasculogenesis / microtubule cytoskeleton organization involved in mitosis / [histone H3]-lysine36 N-trimethyltransferase / histone H3K36 trimethyltransferase activity / embryonic placenta morphogenesis / regulation of mRNA export from nucleus ... mesoderm morphogenesis / coronary vasculature morphogenesis / morphogenesis of a branching structure / peptidyl-lysine trimethylation / cell migration involved in vasculogenesis / microtubule cytoskeleton organization involved in mitosis / [histone H3]-lysine36 N-trimethyltransferase / histone H3K36 trimethyltransferase activity / embryonic placenta morphogenesis / regulation of mRNA export from nucleus / pericardium development / stem cell development / histone H3K36 methyltransferase activity / nucleosome organization / protein-lysine N-methyltransferase activity / response to type I interferon / response to alkaloid / embryonic cranial skeleton morphogenesis / positive regulation of ossification / regulation of protein localization to chromatin / response to metal ion / histone H3 methyltransferase activity / regulation of double-strand break repair via homologous recombination / endodermal cell differentiation / positive regulation of interferon-alpha production / alpha-tubulin binding / mismatch repair / positive regulation of autophagy / forebrain development / 転移酵素; 一炭素原子の基を移すもの; メチル基を移すもの / regulation of cytokinesis / neural tube closure / stem cell differentiation / transcription elongation by RNA polymerase II / response to organic cyclic compound / PKMTs methylate histone lysines / chromosome / regulation of gene expression / angiogenesis / defense response to virus / regulation of DNA-templated transcription / nucleoplasm / nucleus / metal ion binding / cytoplasm 類似検索 - 分子機能 Histone-lysine N-methyltransferase SETD2, animal / Set2 Rpb1 interacting domain / Set2 Rpb1 interacting domain superfamily / SRI (Set2 Rpb1 interacting) domain / SETD2/Set2, SET domain / AWS domain / AWS domain / AWS domain profile. / associated with SET domains / TFIIS/LEDGF domain superfamily ... Histone-lysine N-methyltransferase SETD2, animal / Set2 Rpb1 interacting domain / Set2 Rpb1 interacting domain superfamily / SRI (Set2 Rpb1 interacting) domain / SETD2/Set2, SET domain / AWS domain / AWS domain / AWS domain profile. / associated with SET domains / TFIIS/LEDGF domain superfamily / Cysteine-rich motif following a subset of SET domains / Post-SET domain / Post-SET domain profile. / WW domain / WW/rsp5/WWP domain signature. / WW domain superfamily / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / SET domain superfamily / WW domain / SET domain / SET domain profile. / SET domain 類似検索 - ドメイン・相同性 S-ADENOSYLMETHIONINE / Chem-YHY / Histone-lysine N-methyltransferase SETD2 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.8 Å 詳細データ登録者 Farrow, N.A. / Boriack-Sjodin, P. 引用ジャーナル : Acs Med.Chem.Lett. / 年 : 2021タイトル : Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies.著者: Lampe, J.W. / Alford, J.S. / Boriak-Sjodin, P.A. / Brach, D. / Cosmopoulos, K. / Duncan, K.W. / Eckley, S.T. / Foley, M.A. / Harvey, D.M. / Motwani, V. / Munchhof, M.J. / Raimondi, A. / ... 著者 : Lampe, J.W. / Alford, J.S. / Boriak-Sjodin, P.A. / Brach, D. / Cosmopoulos, K. / Duncan, K.W. / Eckley, S.T. / Foley, M.A. / Harvey, D.M. / Motwani, V. / Munchhof, M.J. / Raimondi, A. / Riera, T.V. / Tang, C. / Thomenius, M.J. / Totman, J. / Farrow, N.A. 履歴 登録 2021年3月9日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2021年9月22日 Provider : repository / タイプ : Initial release改定 1.1 2021年11月3日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID 改定 1.2 2023年10月18日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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