登録情報 | データベース: PDB / ID: 7k6k |
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タイトル | Carbonic Anhydrase II complexed with 4-(2-(3-(3,5-dimethylphenyl)ureido)ethylsulfonamido)benzenesulfonamide |
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要素 | Carbonic anhydrase 2 |
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キーワード | LYASE/LYASE INHIBITOR / Carbonic Anhydrase / CAII / CAIX inhibitor / Structure guided drug design / Structure activity relationship study / Breast Cancer / LYASE / LYASE-LYASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
positive regulation of cellular pH reduction / positive regulation of dipeptide transmembrane transport / regulation of monoatomic anion transport / secretion / cyanamide hydratase / cyanamide hydratase activity / arylesterase activity / regulation of chloride transport / Reversible hydration of carbon dioxide / angiotensin-activated signaling pathway ...positive regulation of cellular pH reduction / positive regulation of dipeptide transmembrane transport / regulation of monoatomic anion transport / secretion / cyanamide hydratase / cyanamide hydratase activity / arylesterase activity / regulation of chloride transport / Reversible hydration of carbon dioxide / angiotensin-activated signaling pathway / positive regulation of synaptic transmission, GABAergic / morphogenesis of an epithelium / regulation of intracellular pH / carbonic anhydrase / carbonate dehydratase activity / carbon dioxide transport / Erythrocytes take up oxygen and release carbon dioxide / Erythrocytes take up carbon dioxide and release oxygen / neuron cellular homeostasis / one-carbon metabolic process / apical part of cell / myelin sheath / zinc ion binding / extracellular exosome / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Carbonic anhydrase, alpha-class, conserved site / Alpha-carbonic anhydrases signature. / Carbonic anhydrase, alpha-class / Alpha carbonic anhydrase domain / Alpha carbonic anhydrase domain superfamily / Eukaryotic-type carbonic anhydrase / Alpha-carbonic anhydrases profile. / Eukaryotic-type carbonic anhydrase類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.306 Å |
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データ登録者 | Andring, J.T. / Singh, S. / McKenna, R. |
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引用 | ジャーナル: Eur.J.Med.Chem. / 年: 2021 タイトル: Handling drug-target selectivity: A study on ureido containing Carbonic Anhydrase inhibitors. 著者: Akgul, O. / Singh, S. / Andring, J.T. / McKenna, R. / Selleri, S. / Carta, F. / Angeli, A. / Supuran, C.T. |
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履歴 | 登録 | 2020年9月20日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2020年12月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年2月24日 | Group: Database references / カテゴリ: citation / Item: _citation.journal_volume / _citation.year |
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改定 1.2 | 2023年10月18日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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