登録情報 | データベース: PDB / ID: 7f61 |
---|
タイトル | Crystal structure of human histamine receptor H3R in complex with antagonist PF03654746 |
---|
要素 | - Histamine H3 receptor
- Soluble cytochrome b562
|
---|
キーワード | MEMBRANE PROTEIN / GPCR / histamine receptor |
---|
機能・相同性 | 機能・相同性情報
Histamine receptors / histamine receptor activity / negative regulation of glutamate secretion / regulation of norepinephrine secretion / G protein-coupled acetylcholine receptor activity / negative regulation of serotonin secretion / adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway / neurotransmitter secretion / G protein-coupled serotonin receptor activity / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger ...Histamine receptors / histamine receptor activity / negative regulation of glutamate secretion / regulation of norepinephrine secretion / G protein-coupled acetylcholine receptor activity / negative regulation of serotonin secretion / adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway / neurotransmitter secretion / G protein-coupled serotonin receptor activity / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / electron transport chain / cognition / presynapse / chemical synaptic transmission / periplasmic space / electron transfer activity / iron ion binding / synapse / dendrite / heme binding / plasma membrane類似検索 - 分子機能 Histamine H3 receptor / Cytochrome b562 / Cytochrome b562 / Cytochrome c/b562 / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family)類似検索 - ドメイン・相同性 Chem-1IB / CHOLESTEROL / Soluble cytochrome b562 / Histamine H3 receptor類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト)
![](img/tx_bacteria.gif) Escherichia coli (大腸菌) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.6 Å |
---|
データ登録者 | Peng, X. / Zhang, H. |
---|
資金援助 | 中国, 6件 組織 | 認可番号 | 国 |
---|
Ministry of Science and Technology (MoST, China) | 2018YFA0508100 | 中国 | National Natural Science Foundation of China (NSFC) | 81722044 | 中国 | National Natural Science Foundation of China (NSFC) | 91753115 | 中国 | National Natural Science Foundation of China (NSFC) | 21778049 | 中国 | National Natural Science Foundation of China (NSFC) | 81861148018 | 中国 | Ministry of Science and Technology (MoST, China) | 2018ZX09711002 | 中国 |
|
---|
引用 | ジャーナル: Nat Commun / 年: 2022 タイトル: Structural basis for recognition of antihistamine drug by human histamine receptor. 著者: Peng, X. / Yang, L. / Liu, Z. / Lou, S. / Mei, S. / Li, M. / Chen, Z. / Zhang, H. |
---|
履歴 | 登録 | 2021年6月23日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
---|
改定 1.0 | 2022年10月26日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2023年11月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
---|
|
---|