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Open data
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Basic information
Entry | Database: PDB / ID: 7ejv | ||||||
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Title | The co-crystal structure of DYRK2 with YK-2-69 | ||||||
![]() | (Dual specificity tyrosine-phosphorylation-regulated kinase 2) x 2 | ||||||
![]() | TRANSFERASE / Phosphorylase Kinase | ||||||
Function / homology | ![]() dual-specificity kinase / negative regulation of calcineurin-NFAT signaling cascade / smoothened signaling pathway / positive regulation of glycogen biosynthetic process / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / ubiquitin ligase complex / protein serine/threonine/tyrosine kinase activity / regulation of signal transduction by p53 class mediator / manganese ion binding / protein tyrosine kinase activity ...dual-specificity kinase / negative regulation of calcineurin-NFAT signaling cascade / smoothened signaling pathway / positive regulation of glycogen biosynthetic process / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / ubiquitin ligase complex / protein serine/threonine/tyrosine kinase activity / regulation of signal transduction by p53 class mediator / manganese ion binding / protein tyrosine kinase activity / Regulation of TP53 Activity through Phosphorylation / cytoskeleton / ribonucleoprotein complex / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / DNA damage response / magnesium ion binding / nucleoplasm / ATP binding / nucleus / cytosol / cytoplasm Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Li, Z. / Xiao, Y. / Yuan, K. / Kuang, W. / Xiuquan, Y. / Yang, P. | ||||||
![]() | ![]() Title: Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer. Authors: Yuan, K. / Li, Z. / Kuang, W. / Wang, X. / Ji, M. / Chen, W. / Ding, J. / Li, J. / Min, W. / Sun, C. / Ye, X. / Lu, M. / Wang, L. / Ge, H. / Jiang, Y. / Hao, H. / Xiao, Y. / Yang, P. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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PDBx/mmCIF format | ![]() | 335.5 KB | Display | ![]() |
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PDB format | ![]() | 270.8 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 5lxdS S: Starting model for refinement |
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Similar structure data | Similarity search - Function & homology ![]() |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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