登録情報 | データベース: PDB / ID: 6jbj |
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タイトル | Cryo-EM structure of human lysosomal cobalamin exporter ABCD4 |
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要素 | ATP-binding cassette sub-family D member 4 |
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キーワード | MEMBRANE PROTEIN / Human ABCD4 / Lysosomal cobalamin exporter / ATP-bound / lysosome-open conformation |
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機能・相同性 | 機能・相同性情報
Defective ABCD4 causes MAHCJ / Cobalamin (Cbl, vitamin B12) transport and metabolism / cobalamin metabolic process / long-chain fatty acid import into peroxisome / very long-chain fatty acid catabolic process / peroxisome organization / peroxisomal membrane / long-chain fatty acid transmembrane transporter activity / fatty acid beta-oxidation / ATPase-coupled transmembrane transporter activity ...Defective ABCD4 causes MAHCJ / Cobalamin (Cbl, vitamin B12) transport and metabolism / cobalamin metabolic process / long-chain fatty acid import into peroxisome / very long-chain fatty acid catabolic process / peroxisome organization / peroxisomal membrane / long-chain fatty acid transmembrane transporter activity / fatty acid beta-oxidation / ATPase-coupled transmembrane transporter activity / ATP-binding cassette (ABC) transporter complex / cellular response to leukemia inhibitory factor / transmembrane transport / peroxisome / membrane => GO:0016020 / lysosomal membrane / endoplasmic reticulum membrane / ATP hydrolysis activity / ATP binding類似検索 - 分子機能 ABC transporter transmembrane region 2 / ABC transporter type 1, transmembrane domain / ABC transporter integral membrane type-1 fused domain profile. / ABC transporter type 1, transmembrane domain superfamily / ABC transporter-like, conserved site / ABC transporters family signature. / ABC transporter / ABC transporter-like, ATP-binding domain / ATP-binding cassette, ABC transporter-type domain profile. / ATPases associated with a variety of cellular activities ...ABC transporter transmembrane region 2 / ABC transporter type 1, transmembrane domain / ABC transporter integral membrane type-1 fused domain profile. / ABC transporter type 1, transmembrane domain superfamily / ABC transporter-like, conserved site / ABC transporters family signature. / ABC transporter / ABC transporter-like, ATP-binding domain / ATP-binding cassette, ABC transporter-type domain profile. / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 ADENOSINE-5'-TRIPHOSPHATE / Lysosomal cobalamin transporter ABCD4類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.6 Å |
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データ登録者 | Xu, D. / Feng, Z. / Hou, W.T. / Jiang, Y.L. / Wang, L. / Sun, L.F. / Zhou, C.Z. / Chen, Y. |
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資金援助 | 中国, 3件 組織 | 認可番号 | 国 |
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Ministry of Science and Technology (China) | 2015CB910103 | 中国 | Chinese Academy of Sciences | XDB08020304 | 中国 | National Natural Science Foundation of China | 31621002 | 中国 |
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引用 | ジャーナル: Cell Res / 年: 2019 タイトル: Cryo-EM structure of human lysosomal cobalamin exporter ABCD4. 著者: Da Xu / Zhang Feng / Wen-Tao Hou / Yong-Liang Jiang / Liang Wang / Linfeng Sun / Cong-Zhao Zhou / Yuxing Chen / ![](img/flg_china.gif) |
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履歴 | 登録 | 2019年1月25日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2019年9月11日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年12月18日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.2 | 2024年3月27日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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