Entry Database : PDB / ID : 6sze Structure visualization Downloads & linksTitle RIP2 Kinase Catalytic Domain complex with 5-Amino-1-Phenylpyrazole-4-Carboxamide. ComponentsReceptor-interacting serine/threonine-protein kinase 2 Details Keywords TRANSFERASE / Fragment Based Drug Design (FBDD) / Receptor interacting protein 2 kinase / RIPK2 / RIP2K / RIP2 / Structure based drug design (SBDD)Function / homology Function and homology informationFunction Domain/homology Component
response to interleukin-18 / positive regulation of T-helper 1 cell differentiation / toll-like receptor 2 signaling pathway / positive regulation of cytokine-mediated signaling pathway / immature T cell proliferation in thymus / positive regulation of T-helper 1 type immune response / positive regulation of xenophagy / LIM domain binding / xenophagy / nucleotide-binding oligomerization domain containing 1 signaling pathway ... response to interleukin-18 / positive regulation of T-helper 1 cell differentiation / toll-like receptor 2 signaling pathway / positive regulation of cytokine-mediated signaling pathway / immature T cell proliferation in thymus / positive regulation of T-helper 1 type immune response / positive regulation of xenophagy / LIM domain binding / xenophagy / nucleotide-binding oligomerization domain containing 1 signaling pathway / CD4-positive, alpha-beta T cell proliferation / positive regulation of protein K63-linked ubiquitination / positive regulation of stress-activated MAPK cascade / caspase binding / cellular response to muramyl dipeptide / CARD domain binding / positive regulation of immature T cell proliferation in thymus / JUN kinase kinase kinase activity / cellular response to peptidoglycan / response to interleukin-12 / positive regulation of CD4-positive, alpha-beta T cell proliferation / activation of cysteine-type endopeptidase activity / nucleotide-binding oligomerization domain containing 2 signaling pathway / positive regulation of macrophage cytokine production / toll-like receptor 4 signaling pathway / response to exogenous dsRNA / cellular response to lipoteichoic acid / positive regulation of interferon-alpha production / signaling adaptor activity / canonical NF-kappaB signal transduction / positive regulation of chemokine production / stress-activated MAPK cascade / JNK cascade / lipopolysaccharide-mediated signaling pathway / ERK1 and ERK2 cascade / positive regulation of interleukin-12 production / p75NTR recruits signalling complexes / positive regulation of interleukin-2 production / positive regulation of interferon-beta production / response to interleukin-1 / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / positive regulation of peptidyl-threonine phosphorylation / positive regulation of interleukin-1 beta production / positive regulation of protein ubiquitination / activated TAK1 mediates p38 MAPK activation / positive regulation of JNK cascade / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / TAK1-dependent IKK and NF-kappa-B activation / NOD1/2 Signaling Pathway / protein homooligomerization / cytokine-mediated signaling pathway / Interleukin-1 signaling / positive regulation of interleukin-6 production / positive regulation of type II interferon production / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of tumor necrosis factor production / Ovarian tumor domain proteases / phosphorylation / Downstream TCR signaling / positive regulation of protein binding / positive regulation of peptidyl-serine phosphorylation / positive regulation of NF-kappaB transcription factor activity / T cell receptor signaling pathway / positive regulation of canonical NF-kappaB signal transduction / adaptive immune response / vesicle / positive regulation of ERK1 and ERK2 cascade / cytoskeleton / non-specific serine/threonine protein kinase / defense response to Gram-positive bacterium / defense response to bacterium / inflammatory response / positive regulation of apoptotic process / innate immune response / protein serine kinase activity / signaling receptor binding / protein serine/threonine kinase activity / apoptotic process / SARS-CoV-2 activates/modulates innate and adaptive immune responses / signal transduction / endoplasmic reticulum / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / protein-containing complex / ATP binding / identical protein binding / plasma membrane / cytosol / cytoplasm Similarity search - Function Receptor-interacting serine/threonine-protein kinase 2 / RIP2, CARD domain / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / Death-like domain superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 ... Receptor-interacting serine/threonine-protein kinase 2 / RIP2, CARD domain / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / Death-like domain superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / FOURIER SYNTHESIS / Resolution : 2.94 Å DetailsAuthors Convery, M.A. / Charnley, A.K. / Shewchuk, L. CitationJournal : Acs Med.Chem.Lett. / Year : 2019Title : Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.Authors: Haffner, C.D. / Charnley, A.K. / Aquino, C.J. / Casillas, L. / Convery, M.A. / Cox, J.A. / Elban, M.A. / Goodwin, N.C. / Gough, P.J. / Haile, P.A. / Hughes, T.V. / Knapp-Reed, B. / ... Authors : Haffner, C.D. / Charnley, A.K. / Aquino, C.J. / Casillas, L. / Convery, M.A. / Cox, J.A. / Elban, M.A. / Goodwin, N.C. / Gough, P.J. / Haile, P.A. / Hughes, T.V. / Knapp-Reed, B. / Kreatsoulas, C. / Lakdawala, A.S. / Li, H. / Lian, Y. / Lipshutz, D. / Mehlmann, J.F. / Ouellette, M. / Romano, J. / Shewchuk, L. / Shu, A. / Votta, B.J. / Zhou, H. / Bertin, J. / Marquis, R.W. History Deposition Oct 2, 2019 Deposition site : PDBE / Processing site : PDBERevision 1.0 Oct 23, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Dec 4, 2019 Group : Database references / Category : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name Revision 1.2 May 15, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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