Entry Database : PDB / ID : 6rx0 Structure visualization Downloads & linksTitle Trypanosoma brucei PTR1 (TbPTR1) in complex with inhibitor 3 (NMT-C0013) ComponentsPteridine reductase Details Keywords OXIDOREDUCTASE / Trypanosoma brucei / pteridine reductase / PTR1 / TbPTR1 / pteridine based inhibitorsFunction / homology Function and homology informationFunction Domain/homology Component
Pteridine reductase / Short-chain dehydrogenase/reductase, conserved site / Short-chain dehydrogenases/reductases family signature. / Enoyl-(Acyl carrier protein) reductase / Short-chain dehydrogenase/reductase SDR / NAD(P)-binding domain superfamily Similarity search - Domain/homologyBiological species Trypanosoma brucei brucei (eukaryote)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.2 Å DetailsAuthors Landi, G. / Pozzi, C. / Mangani, S. Funding support 1items Details Hide detailsOrganization Grant number Country European Union 603240
CitationJournal : J.Med.Chem. / Year : 2022Title : Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1.Authors: Pohner, I. / Quotadamo, A. / Panecka-Hofman, J. / Luciani, R. / Santucci, M. / Linciano, P. / Landi, G. / Di Pisa, F. / Dello Iacono, L. / Pozzi, C. / Mangani, S. / Gul, S. / Witt, G. / ... Authors : Pohner, I. / Quotadamo, A. / Panecka-Hofman, J. / Luciani, R. / Santucci, M. / Linciano, P. / Landi, G. / Di Pisa, F. / Dello Iacono, L. / Pozzi, C. / Mangani, S. / Gul, S. / Witt, G. / Ellinger, B. / Kuzikov, M. / Santarem, N. / Cordeiro-da-Silva, A. / Costi, M.P. / Venturelli, A. / Wade, R.C. History Deposition Jun 7, 2019 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jul 15, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Sep 13, 2023 Group : Data collection / Database referencesCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / citation_author / database_2 Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession Revision 1.2 Jan 24, 2024 Group : Refinement description / Category : pdbx_initial_refinement_model
Show all Show less