登録情報 | データベース: PDB / ID: 6rna |
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タイトル | RIP2 Kinase Catalytic Domain complex with 2({4[(1,3benzothiazol5yl)amino]6(2methylpropane2sulfonyl)quinazolin7yl}oxy)ethan1ol |
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要素 | Receptor-interacting serine/threonine-protein kinase 2 |
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キーワード | TRANSFERASE / Kinase / Structure Based drug discovery |
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機能・相同性 | 機能・相同性情報
response to interleukin-18 / positive regulation of T-helper 1 cell differentiation / toll-like receptor 2 signaling pathway / caspase binding / cellular response to muramyl dipeptide / positive regulation of cytokine-mediated signaling pathway / immature T cell proliferation in thymus / positive regulation of T-helper 1 type immune response / CARD domain binding / positive regulation of xenophagy ...response to interleukin-18 / positive regulation of T-helper 1 cell differentiation / toll-like receptor 2 signaling pathway / caspase binding / cellular response to muramyl dipeptide / positive regulation of cytokine-mediated signaling pathway / immature T cell proliferation in thymus / positive regulation of T-helper 1 type immune response / CARD domain binding / positive regulation of xenophagy / xenophagy / LIM domain binding / nucleotide-binding oligomerization domain containing 1 signaling pathway / positive regulation of protein K63-linked ubiquitination / positive regulation of stress-activated MAPK cascade / CD4-positive, alpha-beta T cell proliferation / positive regulation of immature T cell proliferation in thymus / JUN kinase kinase kinase activity / cellular response to peptidoglycan / response to interleukin-12 / activation of cysteine-type endopeptidase activity / positive regulation of CD4-positive, alpha-beta T cell proliferation / nucleotide-binding oligomerization domain containing 2 signaling pathway / positive regulation of macrophage cytokine production / toll-like receptor 4 signaling pathway / response to exogenous dsRNA / positive regulation of interferon-alpha production / cellular response to lipoteichoic acid / canonical NF-kappaB signal transduction / signaling adaptor activity / lipopolysaccharide-mediated signaling pathway / stress-activated MAPK cascade / positive regulation of chemokine production / JNK cascade / positive regulation of interleukin-12 production / positive regulation of interferon-beta production / p75NTR recruits signalling complexes / positive regulation of interleukin-2 production / ERK1 and ERK2 cascade / response to interleukin-1 / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / positive regulation of interleukin-1 beta production / positive regulation of peptidyl-threonine phosphorylation / positive regulation of protein ubiquitination / activated TAK1 mediates p38 MAPK activation / non-specific protein-tyrosine kinase / positive regulation of JNK cascade / non-membrane spanning protein tyrosine kinase activity / NOD1/2 Signaling Pathway / TAK1-dependent IKK and NF-kappa-B activation / protein homooligomerization / cytokine-mediated signaling pathway / positive regulation of interleukin-6 production / Interleukin-1 signaling / positive regulation of type II interferon production / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of tumor necrosis factor production / Ovarian tumor domain proteases / Downstream TCR signaling / positive regulation of protein binding / positive regulation of peptidyl-serine phosphorylation / positive regulation of NF-kappaB transcription factor activity / T cell receptor signaling pathway / positive regulation of canonical NF-kappaB signal transduction / vesicle / adaptive immune response / positive regulation of ERK1 and ERK2 cascade / cytoskeleton / non-specific serine/threonine protein kinase / defense response to Gram-positive bacterium / defense response to bacterium / inflammatory response / positive regulation of apoptotic process / innate immune response / signaling receptor binding / protein serine kinase activity / protein serine/threonine kinase activity / apoptotic process / SARS-CoV-2 activates/modulates innate and adaptive immune responses / signal transduction / endoplasmic reticulum / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / protein-containing complex / ATP binding / identical protein binding / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Receptor-interacting serine/threonine-protein kinase 2 / RIP2, CARD domain / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / : / Death-like domain superfamily / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Transferase(Phosphotransferase) domain 1 ...Receptor-interacting serine/threonine-protein kinase 2 / RIP2, CARD domain / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / : / Death-like domain superfamily / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Chem-KA2 / Receptor-interacting serine/threonine-protein kinase 2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / フーリエ合成 / 解像度: 2.62 Å |
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データ登録者 | Convery, M.A. / Haile, P.A. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2019 タイトル: Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl ...タイトル: Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases. 著者: Haile, P.A. / Casillas, L.N. / Votta, B.J. / Wang, G.Z. / Charnley, A.K. / Dong, X. / Bury, M.J. / Romano, J.J. / Mehlmann, J.F. / King, B.W. / Erhard, K.F. / Hanning, C.R. / Lipshutz, D.B. / ...著者: Haile, P.A. / Casillas, L.N. / Votta, B.J. / Wang, G.Z. / Charnley, A.K. / Dong, X. / Bury, M.J. / Romano, J.J. / Mehlmann, J.F. / King, B.W. / Erhard, K.F. / Hanning, C.R. / Lipshutz, D.B. / Desai, B.M. / Capriotti, C.A. / Schaeffer, M.C. / Berger, S.B. / Mahajan, M.K. / Reilly, M.A. / Nagilla, R. / Rivera, E.J. / Sun, H.H. / Kenna, J.K. / Beal, A.M. / Ouellette, M.T. / Kelly, M. / Stemp, G. / Convery, M.A. / Vossenkamper, A. / MacDonald, T.T. / Gough, P.J. / Bertin, J. / Marquis, R.W. |
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履歴 | 登録 | 2019年5月8日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年7月17日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年8月7日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.identifier_ORCID |
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改定 1.2 | 2024年1月24日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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