+Search query
-Structure paper
Title | Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 62, Page 6482-6494, Year 2019 |
Publish date | May 8, 2019 (structure data deposition date) |
Authors | Haile, P.A. / Casillas, L.N. / Votta, B.J. / Wang, G.Z. / Charnley, A.K. / Dong, X. / Bury, M.J. / Romano, J.J. / Mehlmann, J.F. / King, B.W. ...Haile, P.A. / Casillas, L.N. / Votta, B.J. / Wang, G.Z. / Charnley, A.K. / Dong, X. / Bury, M.J. / Romano, J.J. / Mehlmann, J.F. / King, B.W. / Erhard, K.F. / Hanning, C.R. / Lipshutz, D.B. / Desai, B.M. / Capriotti, C.A. / Schaeffer, M.C. / Berger, S.B. / Mahajan, M.K. / Reilly, M.A. / Nagilla, R. / Rivera, E.J. / Sun, H.H. / Kenna, J.K. / Beal, A.M. / Ouellette, M.T. / Kelly, M. / Stemp, G. / Convery, M.A. / Vossenkamper, A. / MacDonald, T.T. / Gough, P.J. / Bertin, J. / Marquis, R.W. |
External links | J. Med. Chem. / PubMed:31265286 |
Methods | X-ray diffraction |
Resolution | 2.62 - 2.69 Å |
Structure data | PDB-6rn8: PDB-6rna: |
Chemicals | ChemComp-K9T: ChemComp-CA: ChemComp-HOH: ChemComp-KA2: |
Source |
|
Keywords | TRANSFERASE / Kinase / Structure Based drug discovery |