Entry | Database: PDB / ID: 6qmd |
---|
Title | Small molecule inhibitor of the KEAP1-NRF2 protein-protein interaction |
---|
Components | Kelch-like ECH-associated protein 1 |
---|
Keywords | PROTEIN BINDING / Protein ubiquitination / oxidative stress / kelch motif |
---|
Function / homology | Function and homology information
cellular response to carbohydrate stimulus / KEAP1-NFE2L2 pathway / regulation of epidermal cell differentiation / Neddylation / Antigen processing: Ubiquitination & Proteasome degradation / Ub-specific processing proteases / negative regulation of response to oxidative stress / Cul3-RING ubiquitin ligase complex / centriolar satellite / ubiquitin-like ligase-substrate adaptor activity ...cellular response to carbohydrate stimulus / KEAP1-NFE2L2 pathway / regulation of epidermal cell differentiation / Neddylation / Antigen processing: Ubiquitination & Proteasome degradation / Ub-specific processing proteases / negative regulation of response to oxidative stress / Cul3-RING ubiquitin ligase complex / centriolar satellite / ubiquitin-like ligase-substrate adaptor activity / cellular response to interleukin-4 / inclusion body / regulation of autophagy / actin filament / adherens junction / disordered domain specific binding / cellular response to oxidative stress / midbody / ubiquitin-dependent protein catabolic process / in utero embryonic development / RNA polymerase II-specific DNA-binding transcription factor binding / protein ubiquitination / negative regulation of gene expression / focal adhesion / regulation of DNA-templated transcription / endoplasmic reticulum / protein-containing complex / nucleoplasm / identical protein binding / cytosol / cytoplasmSimilarity search - Function Kelch-type beta propeller / Kelch-like ECH-associated protein 1 / : / BTB-kelch protein / BTB/Kelch-associated / BTB And C-terminal Kelch / BTB And C-terminal Kelch / Kelch / Kelch repeat type 1 / Kelch motif ...Kelch-type beta propeller / Kelch-like ECH-associated protein 1 / : / BTB-kelch protein / BTB/Kelch-associated / BTB And C-terminal Kelch / BTB And C-terminal Kelch / Kelch / Kelch repeat type 1 / Kelch motif / Kelch-type beta propeller / BTB/POZ domain / BTB domain profile. / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain / 6 Propeller / Neuraminidase / SKP1/BTB/POZ domain superfamily / Mainly BetaSimilarity search - Domain/homology |
---|
Biological species | ![](img/tx_mammal.gif) Mus musculus (house mouse) |
---|
Method | X-RAY DIFFRACTION / FOURIER SYNTHESIS / Resolution: 1.94 Å |
---|
Authors | Davies, T.G. |
---|
Citation | Journal: J.Med.Chem. / Year: 2019 Title: Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) ...Title: Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction. Authors: Heightman, T.D. / Callahan, J.F. / Chiarparin, E. / Coyle, J.E. / Griffiths-Jones, C. / Lakdawala, A.S. / McMenamin, R. / Mortenson, P.N. / Norton, D. / Peakman, T.M. / Rich, S.J. / ...Authors: Heightman, T.D. / Callahan, J.F. / Chiarparin, E. / Coyle, J.E. / Griffiths-Jones, C. / Lakdawala, A.S. / McMenamin, R. / Mortenson, P.N. / Norton, D. / Peakman, T.M. / Rich, S.J. / Richardson, C. / Rumsey, W.L. / Sanchez, Y. / Saxty, G. / Willems, H.M.G. / Wolfe 3rd, L. / Woolford, A.J. / Wu, Z. / Yan, H. / Kerns, J.K. / Davies, T.G. |
---|
History | Deposition | Feb 7, 2019 | Deposition site: PDBE / Processing site: PDBE |
---|
Revision 1.0 | Apr 24, 2019 | Provider: repository / Type: Initial release |
---|
Revision 1.1 | May 22, 2019 | Group: Data collection / Database references Category: citation / citation_author ...citation / citation_author / database_PDB_rev / database_PDB_rev_record / pdbx_database_proc Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.name |
---|
Revision 1.2 | May 15, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|