- PDB-6oqo: CDK6 in complex with Cpd24 N-(5-(6-ethyl-2,6-diazaspiro[3.3]hepta... -
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Database: PDB / ID: 6oqo
Title
CDK6 in complex with Cpd24 N-(5-(6-ethyl-2,6-diazaspiro[3.3]heptan-2-yl)pyridin-2-yl)-5-fluoro-4-(4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl)pyrimidin-2-amine
cyclin D2-CDK6 complex / cyclin D3-CDK6 complex / cyclin D1-CDK6 complex / cell dedifferentiation / Drug-mediated inhibition of CDK4/CDK6 activity / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / FBXO family protein binding / lateral ventricle development / negative regulation of myeloid cell differentiation ...cyclin D2-CDK6 complex / cyclin D3-CDK6 complex / cyclin D1-CDK6 complex / cell dedifferentiation / Drug-mediated inhibition of CDK4/CDK6 activity / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / FBXO family protein binding / lateral ventricle development / negative regulation of myeloid cell differentiation / Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) / type B pancreatic cell development / negative regulation of monocyte differentiation / astrocyte development / dentate gyrus development / gliogenesis / regulation of cell motility / cyclin-dependent kinase / Regulation of RUNX1 Expression and Activity / cyclin-dependent protein serine/threonine kinase activity / regulation of hematopoietic stem cell differentiation / positive regulation of cell-matrix adhesion / negative regulation of osteoblast differentiation / generation of neurons / cyclin-dependent protein kinase holoenzyme complex / regulation of G2/M transition of mitotic cell cycle / negative regulation of cellular senescence / negative regulation of cell differentiation / : / negative regulation of cell cycle / cyclin binding / hematopoietic stem cell differentiation / Notch signaling pathway / ruffle / response to virus / regulation of erythrocyte differentiation / Cyclin D associated events in G1 / Oncogene Induced Senescence / G1/S transition of mitotic cell cycle / positive regulation of fibroblast proliferation / negative regulation of epithelial cell proliferation / Senescence-Associated Secretory Phenotype (SASP) / regulation of gene expression / T cell differentiation in thymus / Oxidative Stress Induced Senescence / regulation of cell cycle / protein phosphorylation / cell division / negative regulation of cell population proliferation / protein serine kinase activity / centrosome / positive regulation of gene expression / negative regulation of transcription by RNA polymerase II / signal transduction / nucleoplasm / ATP binding / nucleus / cytoplasm / cytosol Similarity search - Function
Cyclin-dependent kinase 6 / : / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homology
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