Entry Database : PDB / ID : 6dxl Structure visualization Downloads & linksTitle Linked amidobenzimidazole STING agonist ComponentsStimulator of interferon protein Details Keywords immune system/agonist / agonist / DNA-sensor / cGAS / TBK1 / IMMUNE SYSTEM / immune system-agonist complexFunction / homology Function and homology informationFunction Domain/homology Component
STING complex / STAT6-mediated induction of chemokines / protein localization to endoplasmic reticulum / serine/threonine protein kinase complex / proton channel activity / 2',3'-cyclic GMP-AMP binding / STING mediated induction of host immune responses / cyclic-di-GMP binding / IRF3-mediated induction of type I IFN / positive regulation of type I interferon-mediated signaling pathway ... STING complex / STAT6-mediated induction of chemokines / protein localization to endoplasmic reticulum / serine/threonine protein kinase complex / proton channel activity / 2',3'-cyclic GMP-AMP binding / STING mediated induction of host immune responses / cyclic-di-GMP binding / IRF3-mediated induction of type I IFN / positive regulation of type I interferon-mediated signaling pathway / cGAS/STING signaling pathway / reticulophagy / pattern recognition receptor signaling pathway / cytoplasmic pattern recognition receptor signaling pathway / cellular response to exogenous dsRNA / autophagosome membrane / antiviral innate immune response / positive regulation of macroautophagy / cellular response to organic cyclic compound / autophagosome assembly / autophagosome / positive regulation of type I interferon production / cellular response to interferon-beta / signaling adaptor activity / positive regulation of defense response to virus by host / activation of innate immune response / Regulation of innate immune responses to cytosolic DNA / positive regulation of interferon-beta production / endoplasmic reticulum-Golgi intermediate compartment membrane / secretory granule membrane / cytoplasmic vesicle membrane / positive regulation of DNA-binding transcription factor activity / peroxisome / SARS-CoV-1 activates/modulates innate immune responses / positive regulation of protein binding / protein complex oligomerization / regulation of inflammatory response / cytoplasmic vesicle / defense response to virus / RNA polymerase II-specific DNA-binding transcription factor binding / mitochondrial outer membrane / endosome / Golgi membrane / innate immune response / ubiquitin protein ligase binding / Neutrophil degranulation / endoplasmic reticulum membrane / protein kinase binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / perinuclear region of cytoplasm / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / nucleoplasm / identical protein binding / plasma membrane / cytosol Similarity search - Function Stimulator of interferon genes protein / : / Stimulator of interferon genes protein / Stimulator of interferon genes protein, C-terminal domain superfamily / Transmembrane protein 173 / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.45 Å DetailsAuthors Concha, N.O. CitationJournal : Nature / Year : 2018Title : Design of amidobenzimidazole STING receptor agonists with systemic activity.Authors: Ramanjulu, J.M. / Pesiridis, G.S. / Yang, J. / Concha, N. / Singhaus, R. / Zhang, S.Y. / Tran, J.L. / Moore, P. / Lehmann, S. / Eberl, H.C. / Muelbaier, M. / Schneck, J.L. / Clemens, J. / ... Authors : Ramanjulu, J.M. / Pesiridis, G.S. / Yang, J. / Concha, N. / Singhaus, R. / Zhang, S.Y. / Tran, J.L. / Moore, P. / Lehmann, S. / Eberl, H.C. / Muelbaier, M. / Schneck, J.L. / Clemens, J. / Adam, M. / Mehlmann, J. / Romano, J. / Morales, A. / Kang, J. / Leister, L. / Graybill, T.L. / Charnley, A.K. / Ye, G. / Nevins, N. / Behnia, K. / Wolf, A.I. / Kasparcova, V. / Nurse, K. / Wang, L. / Li, Y. / Klein, M. / Hopson, C.B. / Guss, J. / Bantscheff, M. / Bergamini, G. / Reilly, M.A. / Lian, Y. / Duffy, K.J. / Adams, J. / Foley, K.P. / Gough, P.J. / Marquis, R.W. / Smothers, J. / Hoos, A. / Bertin, J. History Deposition Jun 29, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Nov 7, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Nov 21, 2018 Group : Data collection / Database references / Category : citation / citation_author / Item : _citation.pdbx_database_id_PubMed / _citation.titleRevision 1.2 Jan 2, 2019 Group : Data collection / Database references / Category : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_lastRevision 1.3 Mar 13, 2024 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_symmetry / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_symmetry
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