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-Structure paper
| Title | Design of amidobenzimidazole STING receptor agonists with systemic activity. |
|---|---|
| Journal, issue, pages | Nature, Vol. 564, Page 439-443, Year 2018 |
| Publish date | Jun 28, 2018 (structure data deposition date) |
 Authors | Ramanjulu, J.M. / Pesiridis, G.S. / Yang, J. / Concha, N. / Singhaus, R. / Zhang, S.Y. / Tran, J.L. / Moore, P. / Lehmann, S. / Eberl, H.C. ...Ramanjulu, J.M. / Pesiridis, G.S. / Yang, J. / Concha, N. / Singhaus, R. / Zhang, S.Y. / Tran, J.L. / Moore, P. / Lehmann, S. / Eberl, H.C. / Muelbaier, M. / Schneck, J.L. / Clemens, J. / Adam, M. / Mehlmann, J. / Romano, J. / Morales, A. / Kang, J. / Leister, L. / Graybill, T.L. / Charnley, A.K. / Ye, G. / Nevins, N. / Behnia, K. / Wolf, A.I. / Kasparcova, V. / Nurse, K. / Wang, L. / Li, Y. / Klein, M. / Hopson, C.B. / Guss, J. / Bantscheff, M. / Bergamini, G. / Reilly, M.A. / Lian, Y. / Duffy, K.J. / Adams, J. / Foley, K.P. / Gough, P.J. / Marquis, R.W. / Smothers, J. / Hoos, A. / Bertin, J. |
 External links | Nature / PubMed:30405246 |
| Methods | X-ray diffraction |
| Resolution | 1.905 - 2.45 Å |
| Structure data |  PDB-6dxg:  PDB-6dxl: |
| Chemicals |  ChemComp-CA:  ChemComp-HGJ:  ChemComp-HOH:  ChemComp-HG4: |
| Source |
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 Keywords | immune system/agonist / agonist / STING (stimulator of Interferon genes) / transmembrane protein 173 (TMEM173) / IMMUNE SYSTEM / immune system-inhibitor complex / immune system-agonist complex / DNA-sensor / cGAS / TBK1 |
homo sapiens (human)