登録情報 | データベース: PDB / ID: 6ddj |
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タイトル | Crystal Structure of the human BRD2 BD2 bromodimain in complex with a Tetrahydroquinoline analogue |
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要素 | Bromodomain-containing protein 2 |
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キーワード | Transcription/Inhibitor / BET / BRD2 / bromodomain / Inhibitor / Complex / Transcription / Transcription-Inhibitor complex |
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機能・相同性 | 機能・相同性情報
acetylation-dependent protein binding / chromatin looping / RUNX3 regulates p14-ARF / positive regulation of T-helper 17 cell lineage commitment / protein localization to chromatin / neural tube closure / lysine-acetylated histone binding / nucleosome assembly / spermatogenesis / nuclear speck ...acetylation-dependent protein binding / chromatin looping / RUNX3 regulates p14-ARF / positive regulation of T-helper 17 cell lineage commitment / protein localization to chromatin / neural tube closure / lysine-acetylated histone binding / nucleosome assembly / spermatogenesis / nuclear speck / protein phosphorylation / protein serine/threonine kinase activity / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytoplasm類似検索 - 分子機能 NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. ...NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.05 Å |
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データ登録者 | White, S.W. / Yun, M. |
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引用 | ジャーナル: Cancer Res. / 年: 2020 タイトル: Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer. 著者: Slavish, P.J. / Chi, L. / Yun, M.K. / Tsurkan, L. / Martinez, N.E. / Jonchere, B. / Chai, S.C. / Connelly, M. / Waddell, M.B. / Das, S. / Neale, G. / Li, Z. / Shadrick, W.R. / Olsen, R.R. / ...著者: Slavish, P.J. / Chi, L. / Yun, M.K. / Tsurkan, L. / Martinez, N.E. / Jonchere, B. / Chai, S.C. / Connelly, M. / Waddell, M.B. / Das, S. / Neale, G. / Li, Z. / Shadrick, W.R. / Olsen, R.R. / Freeman, K.W. / Low, J.A. / Price, J.E. / Young, B.M. / Bharatham, N. / Boyd, V.A. / Yang, J. / Lee, R.E. / Morfouace, M. / Roussel, M.F. / Chen, T. / Savic, D. / Guy, R.K. / White, S.W. / Shelat, A.A. / Potter, P.M. |
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履歴 | 登録 | 2018年5月10日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年11月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年11月25日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2023年10月11日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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