登録情報 | データベース: PDB / ID: 5zgg |
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タイトル | NMR structure of p75NTR transmembrane domain in complex with NSC49652 |
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要素 | Tumor necrosis factor receptor superfamily member 16 |
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キーワード | MEMBRANE PROTEIN / transmembrane / complex |
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機能・相同性 | 機能・相同性情報
NFG and proNGF binds to p75NTR / detection of temperature stimulus / dorsal aorta development / Ceramide signalling / death receptor activity / positive regulation of odontogenesis of dentin-containing tooth / negative regulation of hair follicle development / negative regulation of fibroblast growth factor receptor signaling pathway / p75NTR negatively regulates cell cycle via SC1 / negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ...NFG and proNGF binds to p75NTR / detection of temperature stimulus / dorsal aorta development / Ceramide signalling / death receptor activity / positive regulation of odontogenesis of dentin-containing tooth / negative regulation of hair follicle development / negative regulation of fibroblast growth factor receptor signaling pathway / p75NTR negatively regulates cell cycle via SC1 / negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / neurotrophin binding / nerve development / Axonal growth inhibition (RHOA activation) / Axonal growth stimulation / nerve growth factor binding / NADE modulates death signalling / Regulated proteolysis of p75NTR / hair follicle morphogenesis / NRAGE signals death through JNK / intracellular glucose homeostasis / odontogenesis of dentin-containing tooth / Rho protein signal transduction / fibroblast growth factor receptor signaling pathway / coreceptor activity / p75NTR recruits signalling complexes / presynaptic modulation of chemical synaptic transmission / NF-kB is activated and signals survival / NRIF signals cell death from the nucleus / negative regulation of cell migration / central nervous system development / positive regulation of apoptotic signaling pathway / axon guidance / intracellular protein transport / circadian regulation of gene expression / neuromuscular junction / small GTPase binding / positive regulation of miRNA transcription / positive regulation of protein localization to nucleus / cellular response to amyloid-beta / transmembrane signaling receptor activity / activation of cysteine-type endopeptidase activity involved in apoptotic process / positive regulation of fibroblast proliferation / cell-cell junction / presynapse / glucose homeostasis / signaling receptor activity / amyloid-beta binding / growth cone / fibroblast proliferation / perikaryon / neuron apoptotic process / dendritic spine / postsynaptic density / calmodulin binding / endosome / ubiquitin protein ligase binding / cell surface / extracellular region / nucleoplasm / membrane / plasma membrane / cytosol類似検索 - 分子機能 Tumour necrosis factor receptor 16 / Tumor necrosis factor receptor 16, N-terminal / Tumor necrosis factor receptor member 16, transmembrane domain / Tumor necrosis factor receptor member 16 trans-membrane domain / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / TNFR/NGFR cysteine-rich region / Death domain profile. ...Tumour necrosis factor receptor 16 / Tumor necrosis factor receptor 16, N-terminal / Tumor necrosis factor receptor member 16, transmembrane domain / Tumor necrosis factor receptor member 16 trans-membrane domain / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / TNFR/NGFR cysteine-rich region / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). / Death domain / Death domain / Death-like domain superfamily類似検索 - ドメイン・相同性 Chem-9F6 / Tumor necrosis factor receptor superfamily member 16類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / molecular dynamics |
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データ登録者 | Lin, Z. / Ibanez, C. |
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資金援助 | 中国, 1件 組織 | 認可番号 | 国 |
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Tianjin | 17JCYBJC24200 | 中国 |
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引用 | ジャーナル: Cell Chem Biol / 年: 2018 タイトル: A Small Molecule Targeting the Transmembrane Domain of Death Receptor p75NTRInduces Melanoma Cell Death and Reduces Tumor Growth. 著者: Goh, E.T.H. / Lin, Z. / Ahn, B.Y. / Lopes-Rodrigues, V. / Dang, N.H. / Salim, S. / Berger, B. / Dymock, B. / Senger, D.L. / Ibanez, C.F. |
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履歴 | 登録 | 2018年3月8日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2019年3月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年9月25日 | Group: Data collection / Database references カテゴリ: citation / citation_author / pdbx_nmr_software Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _pdbx_nmr_software.name |
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