登録情報 データベース : PDB / ID : 5xqx 構造の表示 ダウンロードとリンクタイトル Human CDK8-CYCC in complex with compound 4: N-methyl-4-(4-pyridyl)-1H-pyrrole-2-carboxamide 要素Cyclin-C Cyclin-dependent kinase 8 詳細キーワード TRANSFERASE / CDK8 / CYCLIN C / MEDIATOR COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
CKM complex / G0 to G1 transition / negative regulation of triglyceride metabolic process / mediator complex / Generic Transcription Pathway / cyclin-dependent kinase / cyclin-dependent protein serine/threonine kinase activity / [RNA-polymerase]-subunit kinase / cyclin-dependent protein serine/threonine kinase regulator activity / RSV-host interactions ... CKM complex / G0 to G1 transition / negative regulation of triglyceride metabolic process / mediator complex / Generic Transcription Pathway / cyclin-dependent kinase / cyclin-dependent protein serine/threonine kinase activity / [RNA-polymerase]-subunit kinase / cyclin-dependent protein serine/threonine kinase regulator activity / RSV-host interactions / negative regulation of Notch signaling pathway / cyclin-dependent protein kinase holoenzyme complex / RNA polymerase II CTD heptapeptide repeat kinase activity / ubiquitin ligase complex / PPARA activates gene expression / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / Transcriptional regulation of white adipocyte differentiation / NOTCH1 Intracellular Domain Regulates Transcription / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / ubiquitin protein ligase activity / protein kinase activity / protein ubiquitination / protein serine kinase activity / protein serine/threonine kinase activity / nucleolus / positive regulation of transcription by RNA polymerase II / protein-containing complex / nucleoplasm / ATP binding / identical protein binding / nucleus 類似検索 - 分子機能 Cyclin, C-terminal domain 2 / Cyclin C-terminal domain / Cyclin/Cyclin-like subunit Ssn8 / Cyclin-like / : / Cyclin A; domain 1 / Cyclin, N-terminal / Cyclin, N-terminal domain / Cyclin-like / domain present in cyclins, TFIIB and Retinoblastoma ... Cyclin, C-terminal domain 2 / Cyclin C-terminal domain / Cyclin/Cyclin-like subunit Ssn8 / Cyclin-like / : / Cyclin A; domain 1 / Cyclin, N-terminal / Cyclin, N-terminal domain / Cyclin-like / domain present in cyclins, TFIIB and Retinoblastoma / Cyclin-like superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 N-methyl-4-pyridin-4-yl-1H-pyrrole-2-carboxamide / Cyclin-C / Cyclin-dependent kinase 8 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 解像度 : 2.3 Å 詳細データ登録者 Zhou, Z. / Xu, Z.H. 引用ジャーナル : Bioorg. Med. Chem. Lett. / 年 : 2017タイトル : Discovery of potent and selective CDK8 inhibitors through FBDD approach著者 : Han, X. / Jiang, M. / Zhou, C. / Zhou, Z. / Xu, Z. / Wang, L. / Mayweg, A.V. / Niu, R. / Jin, T.G. / Yang, S. 履歴 登録 2017年6月7日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2017年8月9日 Provider : repository / タイプ : Initial release改定 1.1 2017年8月30日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.name 改定 1.2 2017年9月20日 Group : Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_last改定 1.3 2024年3月27日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
すべて表示 表示を減らす