Entry Database : PDB / ID : 5ulg Structure visualization Downloads & linksTitle Crystal structure of RPE65 in complex with MB-008 and palmitate ComponentsRetinoid isomerohydrolase Details Keywords ISOMERASE/ISOMERASE INHIBITOR / retinoid isomerase / non-heme iron enzyme / inhibitor / ISOMERASE / ISOMERASE-ISOMERASE INHIBITOR complexFunction / homology Function and homology informationFunction Domain/homology Component
retinoid isomerohydrolase / lutein isomerase / beta-carotene 15,15'-dioxygenase activity / retinol isomerase activity / all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity / all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity / zeaxanthin biosynthetic process / The canonical retinoid cycle in rods (twilight vision) / retinal metabolic process / phosphatidylcholine binding ... retinoid isomerohydrolase / lutein isomerase / beta-carotene 15,15'-dioxygenase activity / retinol isomerase activity / all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity / all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity / zeaxanthin biosynthetic process / The canonical retinoid cycle in rods (twilight vision) / retinal metabolic process / phosphatidylcholine binding / cardiolipin binding / phosphatidylserine binding / visual perception / endoplasmic reticulum membrane / identical protein binding / membrane / metal ion binding / plasma membrane Similarity search - FunctionBiological species Bos taurus (cattle)Method X-RAY DIFFRACTION / SYNCHROTRON / FOURIER SYNTHESIS / Resolution : 2.1 Å DetailsAuthors Kiser, P.D. / Palczewski, K. Funding support United States, 2items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Eye Institute (NIH/NEI) EY009339 United States Dept of Veterans Affairs BX002683 United States
CitationJournal : J. Pharmacol. Exp. Ther. / Year : 2017Title : Rational Tuning of Visual Cycle Modulator Pharmacodynamics.Authors : Kiser, P.D. / Zhang, J. / Badiee, M. / Kinoshita, J. / Peachey, N.S. / Tochtrop, G.P. / Palczewski, K. History Deposition Jan 24, 2017 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 17, 2017 Provider : repository / Type : Initial releaseRevision 1.1 May 24, 2017 Group : Database referencesRevision 1.2 Jun 21, 2017 Group : Database references / Category : citationItem : _citation.country / _citation.journal_volume ... _citation.country / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title Revision 1.3 Sep 20, 2017 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.4 Dec 11, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.5 Oct 4, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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