登録情報 | データベース: PDB / ID: 5uih |
---|
タイトル | structure of DHFR with bound phenformin and NADP |
---|
要素 | Dihydrofolate reductase |
---|
キーワード | OXIDOREDUCTASE / DHFR / phenformin / NADP |
---|
機能・相同性 | 機能・相同性情報
methotrexate binding / dihydrofolic acid binding / response to methotrexate / NADP+ binding / folic acid binding / dihydrofolate metabolic process / dihydrofolate reductase / dihydrofolate reductase activity / folic acid metabolic process / NADPH binding ...methotrexate binding / dihydrofolic acid binding / response to methotrexate / NADP+ binding / folic acid binding / dihydrofolate metabolic process / dihydrofolate reductase / dihydrofolate reductase activity / folic acid metabolic process / NADPH binding / tetrahydrofolate biosynthetic process / one-carbon metabolic process / NADP binding / response to xenobiotic stimulus / response to antibiotic / cytosol類似検索 - 分子機能 Dihydrofolate Reductase, subunit A / Dihydrofolate Reductase, subunit A / Dihydrofolate reductase / Dihydrofolate reductase conserved site / Dihydrofolate reductase (DHFR) domain signature. / Dihydrofolate reductase domain / Dihydrofolate reductase / Dihydrofolate reductase (DHFR) domain profile. / Dihydrofolate reductase-like domain superfamily / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 N-(2-phenylethyl)imidodicarbonimidic diamide / BETA-MERCAPTOETHANOL / NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / Dihydrofolate reductase類似検索 - 構成要素 |
---|
生物種 | Escherichia coli (大腸菌) |
---|
手法 | X線回折 / 分子置換 / 解像度: 1.647 Å |
---|
データ登録者 | Pedersen, L.C. / London, R.E. |
---|
引用 | ジャーナル: Biochemistry / 年: 2017 タイトル: A Structural Basis for Biguanide Activity. 著者: Gabel, S.A. / Duff, M.R. / Pedersen, L.C. / DeRose, E.F. / Krahn, J.M. / Howell, E.E. / London, R.E. |
---|
履歴 | 登録 | 2017年1月14日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2017年11月22日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2023年10月4日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_symmetry / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_symmetry / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_symmetry |
---|
|
---|