登録情報 | データベース: PDB / ID: 5o3i |
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タイトル | Human Brd2(BD2) mutant in complex with AL-tBu |
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要素 | Bromodomain-containing protein 2 |
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キーワード | TRANSCRIPTION / The Bromodomain and Extra-Terminal Domain (BET) Family Chromatin binding protein |
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機能・相同性 | 機能・相同性情報
acetylation-dependent protein binding / chromatin looping / RUNX3 regulates p14-ARF / positive regulation of T-helper 17 cell lineage commitment / protein localization to chromatin / neural tube closure / lysine-acetylated histone binding / nucleosome assembly / spermatogenesis / nuclear speck ...acetylation-dependent protein binding / chromatin looping / RUNX3 regulates p14-ARF / positive regulation of T-helper 17 cell lineage commitment / protein localization to chromatin / neural tube closure / lysine-acetylated histone binding / nucleosome assembly / spermatogenesis / nuclear speck / protein serine/threonine kinase activity / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytoplasm類似検索 - 分子機能 : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site ...: / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Chem-9HN / (2~{S})-1-[(2~{S})-2-oxidanylpropoxy]propan-2-ol / Bromodomain-containing protein 2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.2 Å |
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データ登録者 | Chan, K.-H. / Runcie, A.C. / Ciulli, A. |
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資金援助 | 英国, 3件 組織 | 認可番号 | 国 |
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Biotechnology and Biological Sciences Research Council | BB/J001201/2 | 英国 | Biotechnology and Biological Sciences Research Council | BB/G023123/2 | 英国 | European Research Council | ERC-2012-StG-311460 DrugE3CRLs | |
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引用 | ジャーナル: Chem Sci / 年: 2018 タイトル: Optimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition. 著者: Runcie, A.C. / Zengerle, M. / Chan, K.H. / Testa, A. / van Beurden, L. / Baud, M.G.J. / Epemolu, O. / Ellis, L.C.J. / Read, K.D. / Coulthard, V. / Brien, A. / Ciulli, A. |
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履歴 | 登録 | 2017年5月23日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2018年2月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年5月16日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_id_ISSN / _citation.journal_volume ..._citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name |
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改定 1.2 | 2018年7月11日 | Group: Data collection / Derived calculations / Structure summary カテゴリ: pdbx_struct_special_symmetry / struct / Item: _struct.title |
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改定 1.3 | 2024年1月17日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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