登録情報 | データベース: EMDB / ID: EMD-50182 |
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タイトル | cryo-EM structure of human LST2 bound to human mTOR complex 1, focused on RAPTOR |
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マップデータ | |
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試料 | - 複合体: mTORC1 in complex with LST2
- タンパク質・ペプチド: Regulatory-associated protein of mTOR
- タンパク質・ペプチド: Lateral signaling target protein 2 homolog
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キーワード | MTOR / MTORC1 / LST2 / ZFYVE28 / EGFR / TOS / SIGNALING PROTEIN |
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機能・相同性 | 機能・相同性情報
negative regulation of epidermal growth factor-activated receptor activity / positive regulation of pentose-phosphate shunt / TORC1 complex / positive regulation of odontoblast differentiation / TORC1 signaling / negative regulation of epidermal growth factor receptor signaling pathway / cellular response to L-leucine / MTOR signalling / Amino acids regulate mTORC1 / Energy dependent regulation of mTOR by LKB1-AMPK ...negative regulation of epidermal growth factor-activated receptor activity / positive regulation of pentose-phosphate shunt / TORC1 complex / positive regulation of odontoblast differentiation / TORC1 signaling / negative regulation of epidermal growth factor receptor signaling pathway / cellular response to L-leucine / MTOR signalling / Amino acids regulate mTORC1 / Energy dependent regulation of mTOR by LKB1-AMPK / phosphatidylinositol-3-phosphate binding / protein serine/threonine kinase inhibitor activity / positive regulation of osteoclast differentiation / cellular response to osmotic stress / enzyme-substrate adaptor activity / positive regulation of transcription by RNA polymerase III / regulation of cell size / positive regulation of G1/S transition of mitotic cell cycle / Macroautophagy / protein kinase activator activity / mTORC1-mediated signalling / social behavior / HSF1-dependent transactivation / TOR signaling / positive regulation of TOR signaling / cellular response to nutrient levels / positive regulation of lipid biosynthetic process / 14-3-3 protein binding / Regulation of PTEN gene transcription / positive regulation of endothelial cell proliferation / cellular response to starvation / positive regulation of glycolytic process / negative regulation of autophagy / cellular response to amino acid stimulus / positive regulation of peptidyl-threonine phosphorylation / regulation of autophagy / regulation of cell growth / TP53 Regulates Metabolic Genes / cellular response to glucose stimulus / small GTPase binding / cytoplasmic stress granule / positive regulation of peptidyl-serine phosphorylation / early endosome membrane / cellular response to hypoxia / positive regulation of cell growth / protein-macromolecule adaptor activity / lysosome / response to xenobiotic stimulus / lysosomal membrane / neuronal cell body / DNA damage response / dendrite / protein-containing complex binding / protein kinase binding / nucleoplasm / metal ion binding / cytoplasm / cytosol類似検索 - 分子機能 Lateral signaling target protein 2, FYVE domain / : / Raptor, N-terminal CASPase-like domain / Raptor N-terminal CASPase like domain / Raptor N-terminal CASPase like domain / Regulatory associated protein of TOR / FYVE zinc finger / FYVE zinc finger / Protein present in Fab1, YOTB, Vac1, and EEA1 / Zinc finger, FYVE-related ...Lateral signaling target protein 2, FYVE domain / : / Raptor, N-terminal CASPase-like domain / Raptor N-terminal CASPase like domain / Raptor N-terminal CASPase like domain / Regulatory associated protein of TOR / FYVE zinc finger / FYVE zinc finger / Protein present in Fab1, YOTB, Vac1, and EEA1 / Zinc finger, FYVE-related / Zinc finger FYVE/FYVE-related type profile. / HEAT repeat / HEAT repeat / Zinc finger, FYVE/PHD-type / Armadillo-like helical / Armadillo-type fold / Zinc finger, RING/FYVE/PHD-type / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily類似検索 - ドメイン・相同性 Regulatory-associated protein of mTOR / Lateral signaling target protein 2 homolog類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.49 Å |
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データ登録者 | Craigie LM / Maier T |
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資金援助 | スイス, European Union, 2件 Organization | Grant number | 国 |
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Swiss National Science Foundation | 179323 | スイス | H2020 Marie Curie Actions of the European Commission | 812830 | European Union |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2024 タイトル: mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR 著者: Battaglioni S / Craigie LM / Filippini S / Maier T / Hall MN |
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履歴 | 登録 | 2024年4月26日 | - |
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ヘッダ(付随情報) 公開 | 2024年8月14日 | - |
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マップ公開 | 2024年8月14日 | - |
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更新 | 2024年8月14日 | - |
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現状 | 2024年8月14日 | 処理サイト: PDBe / 状態: 公開 |
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