登録情報 データベース : PDB / ID : 4xt9 構造の表示 ダウンロードとリンクタイトル RORgamma (263-509) complexed with GSK2435341A and SRC2 要素LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN Nuclear receptor ROR-gamma 詳細キーワード Unknown protein機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
ligand-activated transcription factor activity / cellular response to sterol / T-helper 17 cell differentiation / regulation of steroid metabolic process / Peyer's patch development / positive regulation of circadian rhythm / oxysterol binding / T-helper cell differentiation / RUNX3 Regulates Immune Response and Cell Migration / negative regulation of thymocyte apoptotic process ... ligand-activated transcription factor activity / cellular response to sterol / T-helper 17 cell differentiation / regulation of steroid metabolic process / Peyer's patch development / positive regulation of circadian rhythm / oxysterol binding / T-helper cell differentiation / RUNX3 Regulates Immune Response and Cell Migration / negative regulation of thymocyte apoptotic process / regulation of fat cell differentiation / regulation of glucose metabolic process / lymph node development / adipose tissue development / xenobiotic metabolic process / circadian regulation of gene expression / DNA-binding transcription repressor activity, RNA polymerase II-specific / Nuclear Receptor transcription pathway / nuclear receptor activity / sequence-specific double-stranded DNA binding / Interleukin-4 and Interleukin-13 signaling / nuclear body / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / zinc ion binding / nucleoplasm / nucleus 類似検索 - 分子機能 Nuclear receptor ROR / Retinoid-related orphan receptors, DNA-binding domain / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors ... Nuclear receptor ROR / Retinoid-related orphan receptors, DNA-binding domain / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)synthetic construct (人工物) 手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.25 Å 詳細データ登録者 Wang, Y. / Ma, Y. 引用ジャーナル : Bioorg.Med.Chem. / 年 : 2015タイトル : Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent ROR gamma t inverse agonists著者: Wang, Y. / Yang, T. / Liu, Q. / Ma, Y. / Yang, L. / Zhou, L. / Xiang, Z. / Cheng, Z. / Lu, S. / Orband-Miller, L.A. / Zhang, W. / Wu, Q. / Zhang, K. / Li, Y. / Xiang, J.N. / Elliott, J.D. / ... 著者 : Wang, Y. / Yang, T. / Liu, Q. / Ma, Y. / Yang, L. / Zhou, L. / Xiang, Z. / Cheng, Z. / Lu, S. / Orband-Miller, L.A. / Zhang, W. / Wu, Q. / Zhang, K. / Li, Y. / Xiang, J.N. / Elliott, J.D. / Leung, S. / Ren, F. / Lin, X. 履歴 登録 2015年1月23日 登録サイト : RCSB / 処理サイト : PDBJ改定 1.0 2015年8月12日 Provider : repository / タイプ : Initial release改定 1.1 2015年9月16日 Group : Database references改定 1.2 2023年11月8日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_initial_refinement_model / pdbx_struct_oper_list / struct_conf / struct_conf_type Item : _citation.journal_id_CSD / _database_2.pdbx_DOI ... _citation.journal_id_CSD / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation
すべて表示 表示を減らす Remark 650 HELIX DETERMINATION METHOD: MOE Remark 700 SHEET DETERMINATION METHOD: MOE