登録情報 | データベース: PDB / ID: 4s1g |
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タイトル | Renin in complex with (S)-1-(3-fluoro-5-(((S)-1-phenylethyl)carbamoyl)benzyl)-4-isopropyl-4-methyl-6-oxotetrahydropyrimidin-2(1H)-iminium |
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要素 | Renin |
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / Aspartic protease / Blood Preasure / angiotensinogen / HYDROLASE-HYDROLASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
renin / juxtaglomerular apparatus development / mesonephros development / response to cGMP / renin-angiotensin regulation of aldosterone production / drinking behavior / regulation of MAPK cascade / response to immobilization stress / angiotensin maturation / amyloid-beta metabolic process ...renin / juxtaglomerular apparatus development / mesonephros development / response to cGMP / renin-angiotensin regulation of aldosterone production / drinking behavior / regulation of MAPK cascade / response to immobilization stress / angiotensin maturation / amyloid-beta metabolic process / Metabolism of Angiotensinogen to Angiotensins / cell maturation / response to cAMP / hormone-mediated signaling pathway / kidney development / insulin-like growth factor receptor binding / regulation of blood pressure / male gonad development / cellular response to xenobiotic stimulus / apical part of cell / peptidase activity / response to lipopolysaccharide / aspartic-type endopeptidase activity / signaling receptor binding / proteolysis / extracellular space / extracellular region / plasma membrane類似検索 - 分子機能 Renin-like domain / Aspartic peptidase, N-terminal / A1 Propeptide / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ...Renin-like domain / Aspartic peptidase, N-terminal / A1 Propeptide / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / フーリエ合成 / 解像度: 2.1 Å |
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データ登録者 | Orth, P. |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2015 タイトル: Iminopyrimidinones: A novel pharmacophore for the development of orally active renin inhibitors. 著者: McKittrick, B.A. / Caldwell, J.P. / Bara, T. / Boykow, G. / Chintala, M. / Clader, J. / Czarniecki, M. / Courneya, B. / Duffy, R. / Fleming, L. / Giessert, R. / Greenlee, W.J. / Heap, C. / ...著者: McKittrick, B.A. / Caldwell, J.P. / Bara, T. / Boykow, G. / Chintala, M. / Clader, J. / Czarniecki, M. / Courneya, B. / Duffy, R. / Fleming, L. / Giessert, R. / Greenlee, W.J. / Heap, C. / Hong, L. / Huang, Y. / Iserloh, U. / Josien, H. / Khan, T. / Korfmacher, W. / Liang, X. / Mazzola, R. / Mitra, S. / Moore, K. / Orth, P. / Rajagopalan, M. / Roy, S. / Sakwa, S. / Strickland, C. / Vaccaro, H. / Voigt, J. / Wang, H. / Wong, J. / Zhang, R. / Zych, A. |
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履歴 | 登録 | 2015年1月13日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2015年2月25日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2015年3月18日 | Group: Database references |
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改定 1.2 | 2015年4月8日 | Group: Database references |
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改定 1.3 | 2018年2月21日 | Group: Structure summary / カテゴリ: struct / Item: _struct.title |
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改定 1.4 | 2020年7月29日 | Group: Data collection / Derived calculations / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_label_asym_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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