Entry Database : PDB / ID : 4rmi Structure visualization Downloads & linksTitle Human Sirt2 in complex with SirReal1 and Ac-Lys-OTC peptide ComponentsAc-Lys-OTC peptide NAD-dependent protein deacetylase sirtuin-2 DetailsKeywords Hydrolase/Hydrolase Inbititor / Hydrolase-Hydrolase Inbititor complexFunction / homology Function and homology informationFunction Domain/homology Component
cellular response to caloric restriction / negative regulation of oligodendrocyte progenitor proliferation / cellular lipid catabolic process / negative regulation of striated muscle tissue development / NAD-dependent histone H4K16 deacetylase activity / positive regulation of meiotic nuclear division / positive regulation of attachment of spindle microtubules to kinetochore / NAD-dependent protein demyristoylase activity / NAD-dependent protein depalmitoylase activity / paranodal junction ... cellular response to caloric restriction / negative regulation of oligodendrocyte progenitor proliferation / cellular lipid catabolic process / negative regulation of striated muscle tissue development / NAD-dependent histone H4K16 deacetylase activity / positive regulation of meiotic nuclear division / positive regulation of attachment of spindle microtubules to kinetochore / NAD-dependent protein demyristoylase activity / NAD-dependent protein depalmitoylase activity / paranodal junction / tubulin deacetylation / lateral loop / NLRP3 inflammasome complex assembly / peptidyl-lysine deacetylation / mitotic nuclear membrane reassembly / negative regulation of NLRP3 inflammasome complex assembly / tubulin deacetylase activity / regulation of exit from mitosis / paranode region of axon / NAD-dependent protein lysine deacetylase activity / Schmidt-Lanterman incisure / positive regulation of fatty acid biosynthetic process / myelination in peripheral nervous system / rDNA heterochromatin formation / protein acetyllysine N-acetyltransferase / chromatin silencing complex / regulation of phosphorylation / Initiation of Nuclear Envelope (NE) Reformation / protein deacetylation / NAD-dependent histone deacetylase activity / juxtaparanode region of axon / positive regulation of oocyte maturation / protein lysine deacetylase activity / meiotic spindle / response to redox state / regulation of myelination / histone acetyltransferase binding / histone deacetylase activity / negative regulation of fat cell differentiation / negative regulation of peptidyl-threonine phosphorylation / positive regulation of execution phase of apoptosis / glial cell projection / positive regulation of cell division / NAD+ ADP-ribosyltransferase activity / NAD+ binding / subtelomeric heterochromatin formation / negative regulation of reactive oxygen species metabolic process / positive regulation of DNA binding / heterochromatin / heterochromatin formation / epigenetic regulation of gene expression / Transferases; Acyltransferases; Transferring groups other than aminoacyl groups / cellular response to epinephrine stimulus / substantia nigra development / centriole / negative regulation of autophagy / meiotic cell cycle / ubiquitin binding / negative regulation of protein catabolic process / mitotic spindle / autophagy / histone deacetylase binding / spindle / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / myelin sheath / chromosome / midbody / cellular response to oxidative stress / growth cone / cellular response to hypoxia / perikaryon / proteasome-mediated ubiquitin-dependent protein catabolic process / DNA-binding transcription factor binding / microtubule / chromosome, telomeric region / regulation of cell cycle / cell division / innate immune response / negative regulation of DNA-templated transcription / centrosome / chromatin binding / nucleolus / perinuclear region of cytoplasm / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / mitochondrion / zinc ion binding / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function Sirtuin, class I / SIR2/SIRT2 'Small Domain' / SIR2/SIRT2 'Small Domain' / Sirtuin, catalytic core small domain superfamily / Sirtuin family / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. / TPP-binding domain / DHS-like NAD/FAD-binding domain superfamily ... Sirtuin, class I / SIR2/SIRT2 'Small Domain' / SIR2/SIRT2 'Small Domain' / Sirtuin, catalytic core small domain superfamily / Sirtuin family / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. / TPP-binding domain / DHS-like NAD/FAD-binding domain superfamily / Rossmann fold / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)synthetic construct (others) Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.45 Å DetailsAuthors Rumpf, T. / Schiedel, M. / Karaman, B. / Roessler, C. / North, B.J. / Lehotzky, A. / Olah, J. / Ladwein, K.I. / Schmidtkunz, K. / Gajer, M. ...Rumpf, T. / Schiedel, M. / Karaman, B. / Roessler, C. / North, B.J. / Lehotzky, A. / Olah, J. / Ladwein, K.I. / Schmidtkunz, K. / Gajer, M. / Pannek, M. / Steegborn, C. / Sinclair, D.A. / Gerhardt, S. / Ovadi, J. / Schutkowski, M. / Sippl, W. / Einsle, O. / Jung, M. CitationJournal : Nat Commun / Year : 2015Title : Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.Authors: Rumpf, T. / Schiedel, M. / Karaman, B. / Roessler, C. / North, B.J. / Lehotzky, A. / Olah, J. / Ladwein, K.I. / Schmidtkunz, K. / Gajer, M. / Pannek, M. / Steegborn, C. / Sinclair, D.A. / ... Authors : Rumpf, T. / Schiedel, M. / Karaman, B. / Roessler, C. / North, B.J. / Lehotzky, A. / Olah, J. / Ladwein, K.I. / Schmidtkunz, K. / Gajer, M. / Pannek, M. / Steegborn, C. / Sinclair, D.A. / Gerhardt, S. / Ovadi, J. / Schutkowski, M. / Sippl, W. / Einsle, O. / Jung, M. History Deposition Oct 21, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Feb 25, 2015 Provider : repository / Type : Initial release