登録情報 データベース : PDB / ID : 4op2 構造の表示 ダウンロードとリンクタイトル GKRP bound to AMG-0471 and Sorbitol-6-Phosphate 要素Glucokinase Regulatory Protein 詳細 キーワード CARBOHYDRATE BINDING PROTEIN/INHIBITOR / SIS domain containing protein / Binds to and inhibits Glucokinase / Glucokinase / CARBOHYDRATE BINDING PROTEIN-INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of glucokinase activity / glucose sensor activity / fructose-6-phosphate binding / carbohydrate derivative metabolic process / urate metabolic process / kinase inhibitor activity / Regulation of Glucokinase by Glucokinase Regulatory Protein / Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) / response to fructose / triglyceride homeostasis ... negative regulation of glucokinase activity / glucose sensor activity / fructose-6-phosphate binding / carbohydrate derivative metabolic process / urate metabolic process / kinase inhibitor activity / Regulation of Glucokinase by Glucokinase Regulatory Protein / Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) / response to fructose / triglyceride homeostasis / enzyme inhibitor activity / response to glucose / protein import into nucleus / glucose homeostasis / carbohydrate binding / enzyme binding / mitochondrion / nucleoplasm / cytoplasm / cytosol 類似検索 - 分子機能 C-terminal lid domain of glucokinase regulatory protein / Glucokinase regulatory protein, conserved site / N-acetylmuramic acid 6-phosphate etherase/glucokinase regulatory protein / Glucokinase regulatory protein family signature. / SIS domain / SIS domain profile. / SIS domain superfamily / Glucose-6-phosphate isomerase like protein; domain 1 / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 Chem-2UX / IODIDE ION / D-SORBITOL-6-PHOSPHATE / Glucokinase regulatory protein 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 2.24 Å 詳細データ登録者 Jordan, S.R. / Chmait, S. 引用ジャーナル : J.Med.Chem. / 年 : 2015タイトル : Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis.著者: Tamayo, N.A. / Norman, M.H. / Bartberger, M.D. / Hong, F.T. / Bo, Y. / Liu, L. / Nishimura, N. / Yang, K.C. / Tadesse, S. / Fotsch, C. / Chen, J. / Chmait, S. / Cupples, R. / Hale, C. / ... 著者 : Tamayo, N.A. / Norman, M.H. / Bartberger, M.D. / Hong, F.T. / Bo, Y. / Liu, L. / Nishimura, N. / Yang, K.C. / Tadesse, S. / Fotsch, C. / Chen, J. / Chmait, S. / Cupples, R. / Hale, C. / Jordan, S.R. / Lloyd, D.J. / Sivits, G. / Van, G. / St Jean, D.J. 履歴 登録 2014年2月4日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2014年7月30日 Provider : repository / タイプ : Initial release改定 1.1 2015年6月24日 Group : Database references改定 1.2 2023年9月20日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description / Structure summary カテゴリ : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ... _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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