- PDB-4o0a: Fragment-Based Discovery of a Potent Inhibitor of Replication Pro... -
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基本情報
登録情報
データベース: PDB / ID: 4o0a
タイトル
Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions
要素
Replication protein A 70 kDa DNA-binding subunit
キーワード
DNA BINDING protein/inhibitor / OB-Fold / Protein-Protein Interaction / DNA BINDING protein-inhibitor complex
機能・相同性
機能・相同性情報
protein localization to chromosome / DNA replication factor A complex / chromatin-protein adaptor activity / single-stranded telomeric DNA binding / Removal of the Flap Intermediate / Activation of the pre-replicative complex / Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) / Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) / protein localization to site of double-strand break / Removal of the Flap Intermediate from the C-strand ...protein localization to chromosome / DNA replication factor A complex / chromatin-protein adaptor activity / single-stranded telomeric DNA binding / Removal of the Flap Intermediate / Activation of the pre-replicative complex / Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) / Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) / protein localization to site of double-strand break / Removal of the Flap Intermediate from the C-strand / G-rich strand telomeric DNA binding / Activation of ATR in response to replication stress / HDR through Single Strand Annealing (SSA) / Impaired BRCA2 binding to RAD51 / site of DNA damage / Presynaptic phase of homologous DNA pairing and strand exchange / telomere maintenance via telomerase / Regulation of HSF1-mediated heat shock response / PCNA-Dependent Long Patch Base Excision Repair / HSF1 activation / meiotic cell cycle / mismatch repair / SUMOylation of DNA damage response and repair proteins / telomere maintenance / Translesion synthesis by REV1 / Translesion synthesis by POLK / Translesion synthesis by POLI / Gap-filling DNA repair synthesis and ligation in GG-NER / Meiotic recombination / nucleotide-excision repair / Fanconi Anemia Pathway / Recognition of DNA damage by PCNA-containing replication complex / Termination of translesion DNA synthesis / G2/M DNA damage checkpoint / Translesion Synthesis by POLH / double-strand break repair via homologous recombination / base-excision repair / HDR through Homologous Recombination (HRR) / PML body / Dual Incision in GG-NER / DNA-templated DNA replication / Formation of Incision Complex in GG-NER / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / Processing of DNA double-strand break ends / site of double-strand break / single-stranded DNA binding / chromosome, telomeric region / DNA replication / Regulation of TP53 Activity through Phosphorylation / DNA recombination / damaged DNA binding / DNA repair / DNA damage response / nucleoplasm / nucleus / metal ion binding 類似検索 - 分子機能
Replication factor-A protein 1, N-terminal domain / Replication factor A protein 1 / Replication factor-A protein 1, N-terminal / Replication protein A, OB domain / Replication protein A OB domain / : / Replication factor A, C-terminal / Replication factor-A C terminal domain / OB-fold nucleic acid binding domain, AA-tRNA synthetase-type / OB-fold nucleic acid binding domain ...Replication factor-A protein 1, N-terminal domain / Replication factor A protein 1 / Replication factor-A protein 1, N-terminal / Replication protein A, OB domain / Replication protein A OB domain / : / Replication factor A, C-terminal / Replication factor-A C terminal domain / OB-fold nucleic acid binding domain, AA-tRNA synthetase-type / OB-fold nucleic acid binding domain / Nucleic acid-binding proteins / OB fold (Dihydrolipoamide Acetyltransferase, E2P) / Nucleic acid-binding, OB-fold / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性
Chem-2P9 / Replication protein A 70 kDa DNA-binding subunit 類似検索 - 構成要素
ReplicationproteinA70kDaDNA-bindingsubunit / RP-A p70 / Replication factor A protein 1 / RF-A protein 1 / Single-stranded DNA-binding protein / ...RP-A p70 / Replication factor A protein 1 / RF-A protein 1 / Single-stranded DNA-binding protein / Replication protein A 70 kDa DNA-binding subunit / N-terminally processed
分子量: 13497.728 Da / 分子数: 1 / 断片: N-terminal domain of Replication Protein A / 変異: E7R / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 遺伝子: RPA1, REPA1, RPA70 / プラスミド: pET15b / 発現宿主: Escherichia coli (大腸菌) / 株 (発現宿主): BL21-BE3 / 参照: UniProt: P27694