登録情報 | データベース: PDB / ID: 4m13 |
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タイトル | Crystal structure of ITK in complex with compound 8 [4-(carbamoylamino)-1-(7-propoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide] |
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要素 | Tyrosine-protein kinase ITK/TSK |
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キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / Kinase / TRANSFERASE-TRANSFERASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
gamma-delta T cell activation / NK T cell differentiation / : / Generation of second messenger molecules / cellular defense response / T cell activation / FCERI mediated Ca+2 mobilization / positive regulation of cytokine production / B cell receptor signaling pathway / non-specific protein-tyrosine kinase ...gamma-delta T cell activation / NK T cell differentiation / : / Generation of second messenger molecules / cellular defense response / T cell activation / FCERI mediated Ca+2 mobilization / positive regulation of cytokine production / B cell receptor signaling pathway / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / cell-cell junction / T cell receptor signaling pathway / adaptive immune response / intracellular signal transduction / signal transduction / ATP binding / nucleus / metal ion binding / plasma membrane / cytosol類似検索 - 分子機能 Tyrosine-protein kinase ITK, SH3 domain / Tyrosine-protein kinase ITK/TSK, catalytic domain / Zinc finger, Btk motif / BTK motif / Zinc finger Btk-type profile. / Bruton's tyrosine kinase Cys-rich motif / : / PH domain / PH domain profile. / Pleckstrin homology domain. ...Tyrosine-protein kinase ITK, SH3 domain / Tyrosine-protein kinase ITK/TSK, catalytic domain / Zinc finger, Btk motif / BTK motif / Zinc finger Btk-type profile. / Bruton's tyrosine kinase Cys-rich motif / : / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / PH-like domain superfamily / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / フーリエ合成 / 解像度: 1.85 Å |
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データ登録者 | Han, S. / Caspers, N.L. |
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引用 | ジャーナル: Biochem.J. / 年: 2014 タイトル: Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors. 著者: Han, S. / Czerwinski, R.M. / Caspers, N.L. / Limburg, D.C. / Ding, W. / Wang, H. / Ohren, J.F. / Rajamohan, F. / McLellan, T.J. / Unwalla, R. / Choi, C. / Parikh, M.D. / Seth, N. / Edmonds, J. ...著者: Han, S. / Czerwinski, R.M. / Caspers, N.L. / Limburg, D.C. / Ding, W. / Wang, H. / Ohren, J.F. / Rajamohan, F. / McLellan, T.J. / Unwalla, R. / Choi, C. / Parikh, M.D. / Seth, N. / Edmonds, J. / Phillips, C. / Shakya, S. / Li, X. / Spaulding, V. / Hughes, S. / Cook, A. / Robinson, C. / Mathias, J.P. / Navratilova, I. / Medley, Q.G. / Anderson, D.R. / Kurumbail, R.G. / Aulabaugh, A. |
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履歴 | 登録 | 2013年8月2日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2014年4月2日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2014年6月4日 | Group: Database references |
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改定 1.2 | 2024年2月28日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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