登録情報 | データベース: PDB / ID: 4lxm |
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タイトル | Crystal Structure of Human Beta Secretase in Complex with compound 12a |
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要素 | Beta-secretase 1 |
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / Structure-based drug design / Aspartyl protease / Membrane / HYDROLASE-HYDROLASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition ...memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / recycling endosome / protein processing / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / aspartic-type endopeptidase activity / early endosome / lysosome / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membrane類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ...Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / フーリエ合成 / 解像度: 2.3 Å |
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データ登録者 | Rondeau, J.M. / Bourgier, E. |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2013 タイトル: Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides. 著者: Rueeger, H. / Lueoend, R. / Machauer, R. / Veenstra, S.J. / Jacobson, L.H. / Staufenbiel, M. / Desrayaud, S. / Rondeau, J.M. / Mobitz, H. / Neumann, U. |
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履歴 | 登録 | 2013年7月30日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2013年8月28日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2013年10月23日 | Group: Other |
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改定 1.2 | 2013年11月20日 | Group: Database references |
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改定 1.3 | 2017年11月15日 | Group: Refinement description / カテゴリ: software |
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