- PDB-4l7f: Co-crystal Structure of JNK1 and AX13587 -
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Basic information
Entry
Database: PDB / ID: 4l7f
Title
Co-crystal Structure of JNK1 and AX13587
Components
Mitogen-activated protein kinase 8
Keywords
Transferase/Transferase Inhibitor / protein kinase fold / protein kinase / jun-c / phosphorylation / Transferase-Transferase Inhibitor complex
Function / homology
Function and homology information
positive regulation of cell killing / JUN phosphorylation / Interleukin-38 signaling / Activation of BMF and translocation to mitochondria / basal dendrite / Activation of BIM and translocation to mitochondria / JUN kinase activity / WNT5:FZD7-mediated leishmania damping / positive regulation of cyclase activity / histone deacetylase regulator activity ...positive regulation of cell killing / JUN phosphorylation / Interleukin-38 signaling / Activation of BMF and translocation to mitochondria / basal dendrite / Activation of BIM and translocation to mitochondria / JUN kinase activity / WNT5:FZD7-mediated leishmania damping / positive regulation of cyclase activity / histone deacetylase regulator activity / positive regulation of NLRP3 inflammasome complex assembly / NRAGE signals death through JNK / Activation of the AP-1 family of transcription factors / Fc-epsilon receptor signaling pathway / cellular response to cadmium ion / mitogen-activated protein kinase / regulation of macroautophagy / response to UV / stress-activated MAPK cascade / response to mechanical stimulus / protein serine/threonine kinase binding / energy homeostasis / JNK cascade / positive regulation of protein metabolic process / NRIF signals cell death from the nucleus / cellular response to amino acid starvation / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / negative regulation of protein binding / regulation of circadian rhythm / FCERI mediated MAPK activation / peptidyl-threonine phosphorylation / cellular response to reactive oxygen species / cellular response to mechanical stimulus / cellular senescence / histone deacetylase binding / rhythmic process / regulation of protein localization / Signaling by ALK fusions and activated point mutants / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / peptidyl-serine phosphorylation / cellular response to oxidative stress / protein phosphatase binding / cellular response to lipopolysaccharide / Oxidative Stress Induced Senescence / response to oxidative stress / positive regulation of apoptotic process / protein phosphorylation / axon / protein serine kinase activity / protein serine/threonine kinase activity / synapse / positive regulation of gene expression / negative regulation of apoptotic process / enzyme binding / nucleoplasm / ATP binding / nucleus / cytoplasm / cytosol Similarity search - Function
Mitogen-activated protein (MAP) kinase, JNK / : / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 ...Mitogen-activated protein (MAP) kinase, JNK / : / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homology
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