登録情報 | データベース: PDB / ID: 4igh |
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タイトル | High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog |
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要素 | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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キーワード | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / anti-viral / quinoline-4-carboxylic acid / redox / dehydrogenase / FMN / membrane / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane ...pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane / mitochondrion / nucleoplasm / plasma membrane / cytosol類似検索 - 分子機能 Dihydroorotate dehydrogenase, class 2 / Dihydroorotate dehydrogenase signature 1. / Dihydroorotate dehydrogenase signature 2. / Dihydroorotate dehydrogenase, conserved site / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Alpha Beta類似検索 - ドメイン・相同性 Chem-1EA / FLAVIN MONONUCLEOTIDE / OROTIC ACID / 3-[decyl(dimethyl)ammonio]propane-1-sulfonate / Dihydroorotate dehydrogenase (quinone), mitochondrial類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.3 Å |
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データ登録者 | Deng, X. / Das, P. / Fontoura, B.M.A. / Phillips, M.A. / De Brabander, J.K. |
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引用 | ジャーナル: ACS MED.CHEM.LETT. / 年: 2013 タイトル: SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity. 著者: Das, P. / Deng, X. / Zhang, L. / Roth, M.G. / Fontoura, B.M. / Phillips, M.A. / De Brabander, J.K. |
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履歴 | 登録 | 2012年12月17日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2013年8月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年9月20日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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