登録情報 | データベース: PDB / ID: 4id1 |
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タイトル | HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor |
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要素 | Gag-Pol polyprotein |
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / HIV Integrase / CCD / DDE motif / dimer interface / allosteric inhibitor / quinoline / HYDROLASE-HYDROLASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
symbiont-mediated activation of host apoptosis / HIV-1 retropepsin / retroviral ribonuclease H / exoribonuclease H / exoribonuclease H activity / host multivesicular body / DNA integration / viral genome integration into host DNA / RNA-directed DNA polymerase / establishment of integrated proviral latency ...symbiont-mediated activation of host apoptosis / HIV-1 retropepsin / retroviral ribonuclease H / exoribonuclease H / exoribonuclease H activity / host multivesicular body / DNA integration / viral genome integration into host DNA / RNA-directed DNA polymerase / establishment of integrated proviral latency / viral penetration into host nucleus / RNA stem-loop binding / RNA-directed DNA polymerase activity / host cell / RNA-DNA hybrid ribonuclease activity / 転移酵素; リンを含む基を移すもの; 核酸を移すもの / symbiont-mediated suppression of host gene expression / viral nucleocapsid / DNA recombination / DNA-directed DNA polymerase / 加水分解酵素; エステル加水分解酵素 / aspartic-type endopeptidase activity / DNA-directed DNA polymerase activity / symbiont entry into host cell / lipid binding / host cell nucleus / host cell plasma membrane / structural molecule activity / virion membrane / proteolysis / DNA binding / zinc ion binding / membrane類似検索 - 分子機能 Ribonuclease H-like superfamily/Ribonuclease H / Reverse transcriptase connection / Reverse transcriptase connection domain / Reverse transcriptase thumb / Reverse transcriptase thumb domain / Integrase Zinc binding domain / Zinc finger integrase-type profile. / Integrase-like, N-terminal / Integrase DNA binding domain / Integrase, C-terminal domain superfamily, retroviral ...Ribonuclease H-like superfamily/Ribonuclease H / Reverse transcriptase connection / Reverse transcriptase connection domain / Reverse transcriptase thumb / Reverse transcriptase thumb domain / Integrase Zinc binding domain / Zinc finger integrase-type profile. / Integrase-like, N-terminal / Integrase DNA binding domain / Integrase, C-terminal domain superfamily, retroviral / Integrase, N-terminal zinc-binding domain / Integrase, C-terminal, retroviral / Integrase DNA binding domain profile. / Immunodeficiency lentiviral matrix, N-terminal / gag gene protein p17 (matrix protein) / RNase H / Integrase core domain / Integrase, catalytic core / Integrase catalytic domain profile. / Retroviral nucleocapsid Gag protein p24, C-terminal domain / Gag protein p24 C-terminal domain / Retropepsin-like catalytic domain / Matrix protein, lentiviral and alpha-retroviral, N-terminal / Ribonuclease H domain / RNase H type-1 domain profile. / Reverse transcriptase (RNA-dependent DNA polymerase) / Reverse transcriptase domain / Reverse transcriptase (RT) catalytic domain profile. / Retropepsins / Retroviral aspartyl protease / Aspartyl protease, retroviral-type family profile. / Peptidase A2A, retrovirus, catalytic / Retrovirus capsid, C-terminal / Retroviral matrix protein / Retrovirus capsid, N-terminal / zinc finger / Zinc knuckle / Zinc finger, CCHC-type superfamily / Zinc finger, CCHC-type / Zinc finger CCHC-type profile. / Nucleotidyltransferase; domain 5 / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Ribonuclease H superfamily / Aspartic peptidase domain superfamily / Ribonuclease H-like superfamily / Reverse transcriptase/Diguanylate cyclase domain / DNA/RNA polymerase superfamily / 2-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_virus.gif) Human immunodeficiency virus type 1 (ヒト免疫不全ウイルス) |
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手法 | X線回折 / 分子置換 / 解像度: 1.87 Å |
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データ登録者 | Feng, L. / Kvaratskhelia, M. |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2013 タイトル: Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation. 著者: Jurado, K.A. / Wang, H. / Slaughter, A. / Feng, L. / Kessl, J.J. / Koh, Y. / Wang, W. / Ballandras-Colas, A. / Patel, P.A. / Fuchs, J.R. / Kvaratskhelia, M. / Engelman, A. |
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履歴 | 登録 | 2012年12月11日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2013年5月1日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2013年5月8日 | Group: Database references |
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改定 1.2 | 2013年6月5日 | Group: Database references |
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改定 1.3 | 2017年11月15日 | Group: Refinement description / カテゴリ: software |
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改定 1.4 | 2023年9月20日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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