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- EMDB-4494: Ovine respiratory supercomplex I+III2 open class 2 -

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Basic information

Entry
Database: EMDB / ID: EMD-4494
TitleOvine respiratory supercomplex I+III2 open class 2
Map dataOvine respiratory supercomplex I III2 open class 2.
Sample
  • Complex: Ovine mitochondrial respiratory supercomplex I+III2
    • Protein or peptide: x 54 types
  • Ligand: x 11 types
Function / homology
Function and homology information


: / : / quinol-cytochrome-c reductase / ubiquinol-cytochrome-c reductase activity / mitochondrial electron transport, ubiquinol to cytochrome c / NADH:ubiquinone reductase (H+-translocating) / apoptotic mitochondrial changes / NADH dehydrogenase activity / : / mitochondrial respiratory chain complex I assembly ...: / : / quinol-cytochrome-c reductase / ubiquinol-cytochrome-c reductase activity / mitochondrial electron transport, ubiquinol to cytochrome c / NADH:ubiquinone reductase (H+-translocating) / apoptotic mitochondrial changes / NADH dehydrogenase activity / : / mitochondrial respiratory chain complex I assembly / mitochondrial electron transport, NADH to ubiquinone / electron transport coupled proton transport / acyl binding / acyl carrier activity / NADH dehydrogenase (ubiquinone) activity / ATP synthesis coupled electron transport / membrane => GO:0016020 / : / ATP metabolic process / respiratory electron transport chain / reactive oxygen species metabolic process / FAD binding / regulation of mitochondrial membrane potential / electron transport chain / metalloendopeptidase activity / mitochondrial intermembrane space / 2 iron, 2 sulfur cluster binding / circadian rhythm / NAD binding / FMN binding / 4 iron, 4 sulfur cluster binding / response to oxidative stress / mitochondrial inner membrane / electron transfer activity / oxidoreductase activity / mitochondrial matrix / heme binding / protein-containing complex binding / proteolysis / nucleoplasm / metal ion binding
Similarity search - Function
Activator of Hsp90 ATPase homologue 1-like / Activator of Hsp90 ATPase homolog 1-like protein / Ubiquinol-cytochrome c reductase 8kDa, N-terminal / Ubiquinol-cytochrome c reductase 8 kDa, N-terminal / : / Globular protein, non-globular alpha/beta subunit / Cytochrome b-c1 complex subunit 8 / UcrQ family / Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily / Cytochrome b-c1 complex subunit 9 ...Activator of Hsp90 ATPase homologue 1-like / Activator of Hsp90 ATPase homolog 1-like protein / Ubiquinol-cytochrome c reductase 8kDa, N-terminal / Ubiquinol-cytochrome c reductase 8 kDa, N-terminal / : / Globular protein, non-globular alpha/beta subunit / Cytochrome b-c1 complex subunit 8 / UcrQ family / Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily / Cytochrome b-c1 complex subunit 9 / Cytochrome b-c1 complex subunit 8 superfamily / Cytochrome b-c1 complex subunit 9 superfamily / Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like / Cytochrome b-c1 complex subunit Rieske, transmembrane domain / Ubiquinol cytochrome reductase transmembrane region / Cytochrome c1, transmembrane anchor, C-terminal / Cytochrome b / : / Ubiquinol-cytochrome c reductase, iron-sulphur subunit / Cytochrome c1 / Cytochrome C1 family / : / Cytochrome b/b6, C-terminal / Cytochrome b(C-terminal)/b6/petD / Cytochrome b/b6 C-terminal region profile. / Cytochrome b/b6, C-terminal domain superfamily / Cytochrome b/b6/petB / FAD-binding domain / NADH:ubiquinone oxidoreductase, ESSS subunit / ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) / FAD binding domain / Peptidase M16, zinc-binding site / Insulinase family, zinc-binding region signature. / Rieske iron-sulphur protein, C-terminal / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1, NDUB1 / MNLL subunit / Cytochrome b/b6, N-terminal / Cytochrome b/b6-like domain superfamily / Cytochrome b/b6 N-terminal region profile. / Di-haem cytochrome, transmembrane / Rieske iron-sulphur protein / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, metazoa / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, animal type / NADH dehydrogenase 1 beta subcomplex subunit 2 / NADH dehydrogenase [ubiquinone] 1 subunit C2, NDUC2 / NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) / NADH dehydrogenase 1, beta subcomplex, subunit 6 / NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit / NADH:ubiquinone oxidoreductase chain 4, N-terminal / NADH:ubiquinone oxidoreductase, chain 2 / NADH dehydrogenase subunit 2, C-terminal / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial / NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit / : / NADH-ubiquinone oxidoreductase chain 4, amino terminus / NADH dehydrogenase subunit 2 C-terminus / NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit / Peptidase M16, C-terminal / Peptidase M16 inactive domain / Peptidase M16, N-terminal / Insulinase (Peptidase family M16) / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8 / NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 / NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 / NADH dehydrogenase 1 alpha subcomplex subunit 3 / Metalloenzyme, LuxS/M16 peptidase-like / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 / NADH dehydrogenase subunit 5, C-terminal / NADH dehydrogenase subunit 5 C-terminus / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 / NADH-ubiquinone oxidoreductase B12 subunit family / NADH:ubiquinone oxidoreductase, NDUFS5-15kDa / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7, NDUB7 / NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 / NDUFB9, LYR domain / NADH:ubiquinone oxidoreductase, iron-sulphur subunit 5 / NDUFA6, LYR domain / NADH dehydrogenase ubiquinone Fe-S protein 4-like superfamily / NADH dehydrogenase ubiquinone Fe-S protein 4 / NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2 / Deoxynucleoside kinase domain / Deoxynucleoside kinase / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 / NADH dehydrogenase ubiquinone Fe-S protein 4, mitochondrial / START-like domain superfamily / ETC complex I subunit conserved region / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 / NADH ubiquinone oxidoreductase subunit NDUFA12 / NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 6 / NADH-quinone oxidoreductase, chain G, C-terminal / NADH-ubiquinone oxidoreductase subunit G, C-terminal / SLBB domain / : / NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8 / NADH-plastoquinone oxidoreductase, chain 5 subgroup / NADH-quinone oxidoreductase, chain M/4 / Rieske [2Fe-2S] domain
Similarity search - Domain/homology
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 / NADH-ubiquinone oxidoreductase chain 1 / NADH-ubiquinone oxidoreductase chain 2 / NADH-ubiquinone oxidoreductase chain 3 / NADH-ubiquinone oxidoreductase chain 4L / NADH-ubiquinone oxidoreductase chain 4 / NADH-ubiquinone oxidoreductase chain 5 / PFC0360w protein / Cytochrome b / Acyl carrier protein ...NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 / NADH-ubiquinone oxidoreductase chain 1 / NADH-ubiquinone oxidoreductase chain 2 / NADH-ubiquinone oxidoreductase chain 3 / NADH-ubiquinone oxidoreductase chain 4L / NADH-ubiquinone oxidoreductase chain 4 / NADH-ubiquinone oxidoreductase chain 5 / PFC0360w protein / Cytochrome b / Acyl carrier protein / NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 / Cytochrome b-c1 complex subunit Rieske, mitochondrial / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 / Complex III subunit 9 / NADH dehydrogenase [ubiquinone] 1 subunit C2 / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 / NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial / NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 / Cytochrome b-c1 complex subunit 8 / NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 / cytochrome c1, heme protein, mitochondrial / Cytochrome b-c1 complex subunit 2, mitochondrial / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 / NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 / Flavoprotein/dehydrogenase / NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
Similarity search - Component
Biological speciesOvis aries (sheep) / Sheep (sheep)
Methodsingle particle reconstruction / cryo EM / Resolution: 4.2 Å
AuthorsLetts JA / Sazanov LA
Funding support Austria, 1 items
OrganizationGrant numberCountry
European Research Council701309 Austria
CitationJournal: Mol Cell / Year: 2019
Title: Structures of Respiratory Supercomplex I+III Reveal Functional and Conformational Crosstalk.
Authors: James A Letts / Karol Fiedorczuk / Gianluca Degliesposti / Mark Skehel / Leonid A Sazanov /
Abstract: The mitochondrial electron transport chain complexes are organized into supercomplexes (SCs) of defined stoichiometry, which have been proposed to regulate electron flux via substrate channeling. We ...The mitochondrial electron transport chain complexes are organized into supercomplexes (SCs) of defined stoichiometry, which have been proposed to regulate electron flux via substrate channeling. We demonstrate that CoQ trapping in the isolated SC I+III limits complex (C)I turnover, arguing against channeling. The SC structure, resolved at up to 3.8 Å in four distinct states, suggests that CoQ oxidation may be rate limiting because of unequal access of CoQ to the active sites of CIII. CI shows a transition between "closed" and "open" conformations, accompanied by the striking rotation of a key transmembrane helix. Furthermore, the state of CI affects the conformational flexibility within CIII, demonstrating crosstalk between the enzymes. CoQ was identified at only three of the four binding sites in CIII, suggesting that interaction with CI disrupts CIII symmetry in a functionally relevant manner. Together, these observations indicate a more nuanced functional role for the SCs.
History
DepositionDec 26, 2018-
Header (metadata) releaseAug 21, 2019-
Map releaseAug 21, 2019-
UpdateNov 25, 2020-
Current statusNov 25, 2020Processing site: PDBe / Status: Released

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Structure visualization

Movie
  • Surface view with section colored by density value
  • Surface level: 0.15
  • Imaged by UCSF Chimera
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  • Surface view colored by height
  • Surface level: 0.15
  • Imaged by UCSF Chimera
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  • Surface view with fitted model
  • Atomic models: PDB-6qc2
  • Surface level: 0.15
  • Imaged by UCSF Chimera
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Movie viewer
Structure viewerEM map:
SurfViewMolmilJmol/JSmol
Supplemental images

emd_4494.png

Downloads & links

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Map

FileDownload / File: emd_4494.map.gz / Format: CCP4 / Size: 512 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
AnnotationOvine respiratory supercomplex I III2 open class 2.
Projections & slices

Image control

Size
Brightness
Contrast
Others
AxesZ (Sec.)Y (Row.)X (Col.)
1.4 Å/pix.
x 512 pix.
= 716.8 Å		1.4 Å/pix.
x 512 pix.
= 716.8 Å		1.4 Å/pix.
x 512 pix.
= 716.8 Å

Surface

Projections

Slices (1/3)

Slices (1/2)

Slices (2/3)

Images are generated by Spider.

Voxel sizeX=Y=Z: 1.4 Å
Density

Histogram

Histogram (log scale)
Contour LevelBy AUTHOR: 0.15 / Movie #1: 0.15
Minimum - Maximum-0.30382824 - 1.1532286
Average (Standard dev.)0.00001359699 (±0.022648644)
SymmetrySpace group: 1
Details

EMDB XML:

Map geometry
Axis orderXYZ
Origin000
Dimensions512512512
Spacing512512512
CellA=B=C: 716.8 Å
α=β=γ: 90.0 °

CCP4 map header:

modeImage stored as Reals
Å/pix. X/Y/Z1.41.41.4
M x/y/z512512512
origin x/y/z0.0000.0000.000
length x/y/z716.800716.800716.800
α/β/γ90.00090.00090.000
MAP C/R/S123
start NC/NR/NS000
NC/NR/NS512512512
D min/max/mean-0.3041.1530.000

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Supplemental data

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Mask #1

Fileemd_4494_msk_1.map
Projections & Slices
AxesZYX

Projections

Slices (1/2)
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Histogram

Histogram (log scale)

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Half map: Ovine respiratory supercomplex I III2 open class 2. Half map 1.

Fileemd_4494_half_map_1.map
AnnotationOvine respiratory supercomplex I III2 open class 2. Half map 1.
Projections & Slices
AxesZYX

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Slices (1/2)
Density Histograms

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Histogram (log scale)

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Half map: Ovine respiratory supercomplex I III2 open class 2. Half map 3.

Fileemd_4494_half_map_2.map
AnnotationOvine respiratory supercomplex I III2 open class 2. Half map 3.
Projections & Slices
AxesZYX

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Slices (1/2)
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Sample components

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Entire : Ovine mitochondrial respiratory supercomplex I+III2

EntireName: Ovine mitochondrial respiratory supercomplex I+III2
Components
  • Complex: Ovine mitochondrial respiratory supercomplex I+III2
    • Protein or peptide: NADH-ubiquinone oxidoreductase chain 3
    • Protein or peptide: NADH-ubiquinone oxidoreductase chain 1
    • Protein or peptide: NADH-ubiquinone oxidoreductase chain 6
    • Protein or peptide: NADH-ubiquinone oxidoreductase chain 4L
    • Protein or peptide: NADH-ubiquinone oxidoreductase chain 5
    • Protein or peptide: NADH-ubiquinone oxidoreductase chain 4
    • Protein or peptide: NADH-ubiquinone oxidoreductase chain 2
    • Protein or peptide: NDUFA11
    • Protein or peptide: NADH:ubiquinone oxidoreductase subunit B5
    • Protein or peptide: Acyl carrier protein
    • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
    • Protein or peptide: NDUFB10
    • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
    • Protein or peptide: NADH:ubiquinone oxidoreductase subunit S5
    • Protein or peptide: NADH:ubiquinone oxidoreductase subunit A3
    • Protein or peptide: NADH:ubiquinone oxidoreductase subunit B3
    • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 subunit C2
    • Protein or peptide: NADH:ubiquinone oxidoreductase subunit B4
    • Protein or peptide: NDUFA13
    • Protein or peptide: NDUFB6
    • Protein or peptide: NADH:ubiquinone oxidoreductase subunit B7
    • Protein or peptide: NADH:ubiquinone oxidoreductase subunit B9
    • Protein or peptide: NADH:ubiquinone oxidoreductase subunit B2
    • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
    • Protein or peptide: NDUFB11
    • Protein or peptide: NDUFC1
    • Protein or peptide: NDUFB1
    • Protein or peptide: NDUFA1
    • Protein or peptide: UQCRC1
    • Protein or peptide: Ubiquinol-cytochrome c reductase core protein 2
    • Protein or peptide: Cytochrome b
    • Protein or peptide: Cytochrome c1
    • Protein or peptide: Cytochrome b-c1 complex subunit Rieske, mitochondrial
    • Protein or peptide: UQCRB
    • Protein or peptide: Ubiquinol-cytochrome c reductase complex III subunit VII
    • Protein or peptide: UQCRQH
    • Protein or peptide: UQCRFS1N
    • Protein or peptide: Ubiquinol-cytochrome c reductase, complex III subunit X
    • Protein or peptide: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
    • Protein or peptide: NDUFV2
    • Protein or peptide: NADH:ubiquinone oxidoreductase core subunit S1
    • Protein or peptide: NDUFS2
    • Protein or peptide: NADH:ubiquinone oxidoreductase core subunit S3
    • Protein or peptide: NDUFS7
    • Protein or peptide: NDUFS8
    • Protein or peptide: NDUFV3
    • Protein or peptide: NDUFS6
    • Protein or peptide: NADH:ubiquinone oxidoreductase subunit S4
    • Protein or peptide: NADH:ubiquinone oxidoreductase subunit A9
    • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
    • Protein or peptide: NDUFA5
    • Protein or peptide: NADH:ubiquinone oxidoreductase subunit A6
    • Protein or peptide: NDUFA7
    • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
  • Ligand: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE
  • Ligand: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
  • Ligand: S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate
  • Ligand: PROTOPORPHYRIN IX CONTAINING FE
  • Ligand: HEME C
  • Ligand: FE2/S2 (INORGANIC) CLUSTER
  • Ligand: CARDIOLIPIN
  • Ligand: IRON/SULFUR CLUSTER
  • Ligand: FLAVIN MONONUCLEOTIDE
  • Ligand: ZINC ION
  • Ligand: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

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Supramolecule #1: Ovine mitochondrial respiratory supercomplex I+III2

SupramoleculeName: Ovine mitochondrial respiratory supercomplex I+III2 / type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1-#54
Details: Open class 2 from ovine mitochondrial respiratory SC I+III2
Source (natural)Organism: Ovis aries (sheep) / Organ: Heart / Tissue: Cardiac / Organelle: Mitochondria / Location in cell: Mitochondrial inner membrane
Molecular weightTheoretical: 1.4 MDa

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Macromolecule #1: NADH-ubiquinone oxidoreductase chain 3

MacromoleculeName: NADH-ubiquinone oxidoreductase chain 3 / type: protein_or_peptide / ID: 1 / Number of copies: 1 / Enantiomer: LEVO / EC number: NADH:ubiquinone reductase (H+-translocating)
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 13.10652 KDa
SequenceString:
MNLMITLLTN FTLATLLVTI AFWLPQLNVY SEKTSPYECG FDPMGSARLP FSMKFFLVAI TFLLFDLEIA LLLPLPWASQ TTNLNTMLT MALLLIFLLA VSLAYEWTQK GLEWTE

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Macromolecule #2: NADH-ubiquinone oxidoreductase chain 1

MacromoleculeName: NADH-ubiquinone oxidoreductase chain 1 / type: protein_or_peptide / ID: 2 / Number of copies: 1 / Enantiomer: LEVO / EC number: NADH:ubiquinone reductase (H+-translocating)
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 35.884902 KDa
SequenceString: MFMINVLTLI IPILLAVAFL TLVERKVLGY MQFRKGPNVV GPYGLLQPIA DAIKLFIKEP LRPATSSISM FILAPILALT LALTMWIPL PMPYPLINMN LGVLFMLAMS SLAVYSILWS GWASNSKYAL IGALRAVAQT ISYEVTLAII LLSVLLMNGS F TLSTLIIT ...String:
MFMINVLTLI IPILLAVAFL TLVERKVLGY MQFRKGPNVV GPYGLLQPIA DAIKLFIKEP LRPATSSISM FILAPILALT LALTMWIPL PMPYPLINMN LGVLFMLAMS SLAVYSILWS GWASNSKYAL IGALRAVAQT ISYEVTLAII LLSVLLMNGS F TLSTLIIT QEQVWLIFPA WPLAMMWFIS TLAETNRAPF DLTEGESELV SGFNVEYAAG PFALFFMAEY ANIIMMNIFT TT LFLGAFH NPYMPELYTI NFTIKSLLLS ITFLWIRASY PRFRYDQLMH LLWKNFLPLT LALCMWHVSL PILLSSIPPQ T

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Macromolecule #3: NADH-ubiquinone oxidoreductase chain 6

MacromoleculeName: NADH-ubiquinone oxidoreductase chain 6 / type: protein_or_peptide / ID: 3 / Number of copies: 1 / Enantiomer: LEVO / EC number: NADH:ubiquinone reductase (H+-translocating)
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 19.126619 KDa
SequenceString:
MMTYIVFILS IIFVMGFVGF SSKPSPIYGG LGLIVSGGVG CGIVLNFGGS FLGLMVFLIY LGGMMVVFGY TTAMATEQYP EVWVSNKVV LGTFITGLLM EFLMVYYVLK DKEVEIVFKF NGMGDWVIYD TGDSGFFSEE AMGIAALYSY GTWLVIVTGW S LLIGVVVI MEITRGN

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Macromolecule #4: NADH-ubiquinone oxidoreductase chain 4L

MacromoleculeName: NADH-ubiquinone oxidoreductase chain 4L / type: protein_or_peptide / ID: 4 / Number of copies: 1 / Enantiomer: LEVO / EC number: NADH:ubiquinone reductase (H+-translocating)
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 10.840228 KDa
SequenceString:
MSLVYMNIMM AFTVSLTGLL MYRSHLMSSL LCLEGMMLSL FILATLMILN SHFTLASMMP IILLVFAACE AALGLSLLVM VSNTYGTDY VQNLNLLQC

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Macromolecule #5: NADH-ubiquinone oxidoreductase chain 5

MacromoleculeName: NADH-ubiquinone oxidoreductase chain 5 / type: protein_or_peptide / ID: 5 / Number of copies: 1 / Enantiomer: LEVO / EC number: NADH:ubiquinone reductase (H+-translocating)
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 68.410898 KDa
SequenceString: MNLFSSLTLV TLILLTMPIA AINFNTHKFT NYPLYVKTTI SCAFITSMIP TMMFIHTGQE MIISNWHWLT IQTLKLSLSF KMDFFSMMF VPVALFVTWS IMEFSMWYMH SDPNINQFFK YLLLFLITML ILVTANNLFQ LFIGWEGVGI MSFLLIGWWY G RTDANTAA ...String:
MNLFSSLTLV TLILLTMPIA AINFNTHKFT NYPLYVKTTI SCAFITSMIP TMMFIHTGQE MIISNWHWLT IQTLKLSLSF KMDFFSMMF VPVALFVTWS IMEFSMWYMH SDPNINQFFK YLLLFLITML ILVTANNLFQ LFIGWEGVGI MSFLLIGWWY G RTDANTAA LQAILYNRIG DIGFILAMAW FLINLNTWDL QQIFMLNPND SNLPLMGLIL AATGKSAQFG LHPWLPSAME GP TPVSALL HSSTMVVAGI FLLIRFYPLT ENNKFGQSIM LCLGAMTTLF TAMCALTQND IKKIIAFSTS SQLGLMMVTI GIN QPHLAF LHICTHAFFK AMLFMCSGSI IHSLNDEQDI RKMGGLFKAM PFTTTALIIG SLALTGMPFL TGFYSKDLII ESAN TSYTN AWALLMTLVA TSFTAIYSTR IIFFALLGQP RFPTLININE NNPFLINSIK RLLIGSLFAG FIISNNIPPM TIPQM TMPH YLKMTALTVT ILGFILALEI SNTTHYLKFN YPSNTFKFSN LLGYYPTIMH RLTPYMNLTM SQKSASSLLD LIWLET ILP KTISLAQMKM STTITSQKGL IKLYFLSFLI TILISTTLLN FHE

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Macromolecule #6: NADH-ubiquinone oxidoreductase chain 4

MacromoleculeName: NADH-ubiquinone oxidoreductase chain 4 / type: protein_or_peptide / ID: 6 / Number of copies: 1 / Enantiomer: LEVO / EC number: NADH:ubiquinone reductase (H+-translocating)
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 52.058734 KDa
SequenceString: MLKYIIPTMM LMPLTWLSKN SMIWINTTLH SLLISLTSLL LLNQFGDNSL NFSLTFFSDS LSTPLLILTM WLLPLMLMAS QHHLSKENL ARKKLFISML ILLQLFLIMT FTATELIFFY IMFEATLVPT LIIITRWGNQ TERLNAGLYF LFYTLAGSLP L LVALIYIQ ...String:
MLKYIIPTMM LMPLTWLSKN SMIWINTTLH SLLISLTSLL LLNQFGDNSL NFSLTFFSDS LSTPLLILTM WLLPLMLMAS QHHLSKENL ARKKLFISML ILLQLFLIMT FTATELIFFY IMFEATLVPT LIIITRWGNQ TERLNAGLYF LFYTLAGSLP L LVALIYIQ NTMGSLNFLI LQYWVQPMPN SWSNTFMWLA CMMAFMVKMP LYGLHLWLPK AHVEAPIAGS MVLAAILLKL GG YGMMRIT LLLNPITDFM AYPFIMLSLW GMIMTSSICL RQTDLKSLIA YSSVSHMALV IVAILIQTPW SYMGATALMI AHG LTSSML FCLANSNYER VHSRTMILAR GLQTLLPLMA AWWLLASLTN LALPPSINLI GELFVVMSTF SWSNITIILM GLNM VITAL YSLYMLITTQ RGKHTHHINN ILPSFTRENA LMSLHMLPLL LLSLNPKIIL GPLY

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Macromolecule #7: NADH-ubiquinone oxidoreductase chain 2

MacromoleculeName: NADH-ubiquinone oxidoreductase chain 2 / type: protein_or_peptide / ID: 7 / Number of copies: 1 / Enantiomer: LEVO / EC number: NADH:ubiquinone reductase (H+-translocating)
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 39.149805 KDa
SequenceString: MNPIILIIIL MTVMLGTIIV MISTHWLLIW IGFEMNMLAI IPIMMKKHNP RATEASTKYF LTQSTASMLL MMAIIINLMF SGQWTVMKL FNPMASMLMT MALAMKLGMA PFHFWVPEVT QGIPLSSGLI LLTWQKLAPM SVLYQILPSI NLDLILTLSI L SITIGGWG ...String:
MNPIILIIIL MTVMLGTIIV MISTHWLLIW IGFEMNMLAI IPIMMKKHNP RATEASTKYF LTQSTASMLL MMAIIINLMF SGQWTVMKL FNPMASMLMT MALAMKLGMA PFHFWVPEVT QGIPLSSGLI LLTWQKLAPM SVLYQILPSI NLDLILTLSI L SITIGGWG GLNQTQLRKI MAYSSIAHMG WMTAVLLYNP TMTLLNLIIY IIMTSTMFTL FMANSTTTTL SLSHTWNKAP IM TILVLIT LLSMGGLPPL SGFMPKWMII QEMTKNDSII LPTLMAITAL LNLYFYMRLT YSTALTMFPS TNNMKMKWQF PTT KRMTLL PTMTVLSTML LPLTPILSIL E

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Macromolecule #8: NDUFA11

MacromoleculeName: NDUFA11 / type: protein_or_peptide / ID: 8 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 14.610776 KDa
SequenceString:
AKTLLHQYWD IPEGTECHRK TYAATSIGGA SGLVVSAYSV ALKTPTSFLE GVARTGRYTF TAAAIGAIFG LTSCISAQVR EKPDDPLNY LIGGCAGGLT LGARTRSYGI GAAACAYMGL TAALVKMGQL EGWKVFAEPK V

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Macromolecule #9: NADH:ubiquinone oxidoreductase subunit B5

MacromoleculeName: NADH:ubiquinone oxidoreductase subunit B5 / type: protein_or_peptide / ID: 9 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 16.714369 KDa
SequenceString:
SGDHGKRLFI IKPSGFYDKR FLKLLRFYIL LTGIPVVIGI TLINVFIGEA ELAEIPEGYV PEHWEYFKHP ISRWIARTFF DAPEKNYER TMAILQIESE KAELRLKELE VRRLMRAKGD GPWFQYPTID KALIDHSPKA TPDN

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Macromolecule #10: Acyl carrier protein

MacromoleculeName: Acyl carrier protein / type: protein_or_peptide / ID: 10 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 10.119541 KDa
SequenceString:
SDAPPLTLEG IKDRVLYVLK LYDKIDPEKL SVNSHFMKDL GLDSLDQVEI IMAMEDEFGF EIPDIDAEKL MCPQEIVDYI ADKKDVYE

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Macromolecule #11: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

MacromoleculeName: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
type: protein_or_peptide / ID: 11 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 20.008014 KDa
SequenceString:
PGIVELPSLE DLKVQEVKVS SSVLKAAAHH YGAQCDKPNK EFMLCRWEEK DPRRCLEEGK LVNQCALEFF RQIKRHCAEP FTEYWTCID YSGLQLFRRC RKEQAQFDKC VLDKLGWVRP DLGELSKVTK VKTDRPLPEN PYHSRARPEP NPEVEGDLKP A RHGSRLFF WTM

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Macromolecule #12: NDUFB10

MacromoleculeName: NDUFB10 / type: protein_or_peptide / ID: 12 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Ovis aries (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 20.880752 KDa
SequenceString:
PDSWDKDVYP EPPRRTPAPS PQTSLPNPIT YLTKAFDLLV DRPVTLVREF IERQHAKNKY YYYHREFRRV PDITECHEKD VLCMFEAEM QWKRDYKVDQ EIVNIIQERL KACQQREGES HRQNCAKELQ QFTQVVKAYQ DRYHDLGAHY SARKCLAKQK Q RMLAERKA TKEAAAA

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Macromolecule #13: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mi...

MacromoleculeName: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
type: protein_or_peptide / ID: 13 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 36.803762 KDa
SequenceString: LQYGPLAYIL GEKTTKKMTE NSKLITVDGN ICSGKSKLAK EVAEKLGLKH FPEAGIHYAD STTGDGKPLP VRFSGNCSLE KFYDDPKSN DGNSYRLQAW LYASRLLQYA DALEHLLSTG QGVVLERSIY SDFVFLEAMY RQGFIRKQCV DHYNQVKKVT V CEYLPPHV ...String:
LQYGPLAYIL GEKTTKKMTE NSKLITVDGN ICSGKSKLAK EVAEKLGLKH FPEAGIHYAD STTGDGKPLP VRFSGNCSLE KFYDDPKSN DGNSYRLQAW LYASRLLQYA DALEHLLSTG QGVVLERSIY SDFVFLEAMY RQGFIRKQCV DHYNQVKKVT V CEYLPPHV VIYVDVPVSE VQSRIQKKGN PHEMKITSAY LQDIENVYKG TFLPEMSEKC EVLQYSAWEA EDAEKVVEDI QY LKYDKGP WLDQDDRKLH NLRMLVQDKL EVLNYTSIPV FLPEVTIGAH QSDRVFQEFT ELPGRKYRAG YNEDVGDKWI WLK

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Macromolecule #14: NADH:ubiquinone oxidoreductase subunit S5

MacromoleculeName: NADH:ubiquinone oxidoreductase subunit S5 / type: protein_or_peptide / ID: 14 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 12.474397 KDa
SequenceString:
PFFDVQKKLG VDLDHWMTIQ SAEQPHRIPA RCHAFEKEWI ECAHGIGSIR AEKECKIEFE DFRECLLRQK TMKRLNAIKR QRDKLIKEG KYTPPPHHSG QEDLRP

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Macromolecule #15: NADH:ubiquinone oxidoreductase subunit A3

MacromoleculeName: NADH:ubiquinone oxidoreductase subunit A3 / type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 9.194655 KDa
SequenceString:
APRVAAFLKN VWAKEPVLVA SFAIAGLAVI LPTLSPYTKY SLMINRATPY NYPVPLRDDG NMPDVPSHPQ DPQGPSLEWL KRL

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Macromolecule #16: NADH:ubiquinone oxidoreductase subunit B3

MacromoleculeName: NADH:ubiquinone oxidoreductase subunit B3 / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 11.015482 KDa
SequenceString:
AHGHGHEHGP SKMELPDYKQ WKIEGTPLET VQEKLAARGL RDPWGRNEAW RYMGGFANNV SFVGALLKGF KWGFAAFVVA VGAEYYLES QKKDKKHH

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Macromolecule #17: NADH dehydrogenase [ubiquinone] 1 subunit C2

MacromoleculeName: NADH dehydrogenase [ubiquinone] 1 subunit C2 / type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 14.23142 KDa
SequenceString:
MMTGRQARAP LQFLPDEARS LPPPKLTDPR LAYIGFLGYC SGLIDNAIRR RPVLSAGLHR QFLYITSFVF VGYYLLKRQD YMYAVRDHD MFSYIKSHPE DFPEKDKKTY REVFEEFHPV R

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Macromolecule #18: NADH:ubiquinone oxidoreductase subunit B4

MacromoleculeName: NADH:ubiquinone oxidoreductase subunit B4 / type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 14.975999 KDa
SequenceString:
SFPKYEPSRL ASLPTTLDPA EYDISSETRK AQAERLAIRS RLKREYQLQY NDPSRRGVVE DPALIRWTCA RSANVYPNFR PNTKTSLLG ALFGIGPLIF WYYVFKTDRD RKEKLIQEGK LDRTFNISY

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Macromolecule #19: NDUFA13

MacromoleculeName: NDUFA13 / type: protein_or_peptide / ID: 19 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Ovis aries (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 16.635264 KDa
SequenceString:
AASKVKQDMP PVGGYGPIDY KRNLPRRGLS GYSMFAVGIG ALLFGYWSMM RWNRERRRLQ IEDFEARIAL MPLLQAEKDR RVLQMLREN LEEEATIMKD VPGWKVGESV FHTTRWVTPM MGELYGLRTG EEILSSTYGF IWYT

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Macromolecule #20: NDUFB6

MacromoleculeName: NDUFB6 / type: protein_or_peptide / ID: 20 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 15.433929 KDa
SequenceString:
SGYTPDEKLR LQQLRELRRR WLKDQELSPR EPVLPPRRVS PVERFWNKFL QDGALWKNVI YKTYRHSIFA FTHVLIPVWI IHYYLKYHV TTKPYTIVEK KPRIFPGDTI LETGEVIPPM KEFPDQHH

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Macromolecule #21: NADH:ubiquinone oxidoreductase subunit B7

MacromoleculeName: NADH:ubiquinone oxidoreductase subunit B7 / type: protein_or_peptide / ID: 21 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 14.645718 KDa
SequenceString:
GAHLARRYLG DASVEPEPLR MPTFPPDYGF PERKEREMVA TQQEMNDAQL VLQQRDYCAH YLIRFLKCKR DSFPNFLACK HEQHDWDYC EHLDYVKRMK EFERERRLLQ RKKRREQREA

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Macromolecule #22: NADH:ubiquinone oxidoreductase subunit B9

MacromoleculeName: NADH:ubiquinone oxidoreductase subunit B9 / type: protein_or_peptide / ID: 22 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 21.648715 KDa
SequenceString:
AFLPSAAYLT HQQKVLQLYK RALRHLESRC VHRDKYRYFA CLLRARFDEH KNEKDMVKAT QLLREAEKEF WHGQHPQPYI FPESPGGTS YERYECYKVP EWCLDDWHPS EKAMYPDYFA KREQWKKLRR ESWEREVKQL QEETPVGGPR TEALPPARKQ G DLPPLWWH IVTRPRERPM

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Macromolecule #23: NADH:ubiquinone oxidoreductase subunit B2

MacromoleculeName: NADH:ubiquinone oxidoreductase subunit B2 / type: protein_or_peptide / ID: 23 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 8.500289 KDa
SequenceString:
AGGGAHIEPR YRQFPQLTRS QVIQAEFFSA TMWFWILWRF WHDSDAVLGH FPYPDPSQWT DEELGIPPDD ED

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Macromolecule #24: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mito...

MacromoleculeName: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
type: protein_or_peptide / ID: 24 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 18.81807 KDa
SequenceString:
ASHITKDMLP GPYPKTPEER AAAAKKYNMR VEDYEPYPDD GMGYGDYPKL PDRSQQERDP WYDWDHPDLR LNWGEPMHWD LDMYIRNRV DTSPTPVNWN LMCKHLFGFV AFMLFMFWVG ETYPTYQPVG PKQYPYNNLY LERGGDPNKE PEPVVHYEI

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Macromolecule #25: NDUFB11

MacromoleculeName: NDUFB11 / type: protein_or_peptide / ID: 25 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 14.455033 KDa
SequenceString:
ESSSSRAVIA PSTLAGKRPS EPTLRWQEDP EPEDENLYEK NPDSHGYDKD PAVDVWNMRV VFFFGFSIVL VLGSTFVAYL PDYRMQEWA RREAERLVKY REAHGLPLME SNCFDPSKIQ LPEDED

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Macromolecule #26: NDUFC1

MacromoleculeName: NDUFC1 / type: protein_or_peptide / ID: 26 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Ovis aries (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 5.808645 KDa
SequenceString:
KFYIQEPPHG SPNWLKVGLT LGTSAFLWIY LIKQHNEDVL EYKRRNGLE

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Macromolecule #27: NDUFB1

MacromoleculeName: NDUFB1 / type: protein_or_peptide / ID: 27 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 6.930083 KDa
SequenceString:
MNLLQVVRDH WIHVLVPVGF VFGYYLDRKN DEKLAAFRNK SLLYKRELKP NEEVTWK

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Macromolecule #28: NDUFA1

MacromoleculeName: NDUFA1 / type: protein_or_peptide / ID: 28 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Ovis aries (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 8.211519 KDa
SequenceString:
MWFEVLPGIA VMGVCLFIPG MATARIHRFS NGGREKRVAH YSYQWYLMER DRRVSGVNRY YVSKGLENID

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Macromolecule #29: UQCRC1

MacromoleculeName: UQCRC1 / type: protein_or_peptide / ID: 29 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Ovis aries (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 49.385414 KDa
SequenceString: TATYAQALQS VPETQVSQLD NGLRVASEQS SQPTCTVGVW IDAGSRYETE KNNGAGYFVE HLAFKGTKNR PGNALEKEVE SMGAHLNAY STREHTAYYI KALSKDLPKA VELLADIVQN CSLEDSQIEK ERDVILQELQ ENDTSMRDVV FNYLHATAFQ G TPLAQSVE ...String:
TATYAQALQS VPETQVSQLD NGLRVASEQS SQPTCTVGVW IDAGSRYETE KNNGAGYFVE HLAFKGTKNR PGNALEKEVE SMGAHLNAY STREHTAYYI KALSKDLPKA VELLADIVQN CSLEDSQIEK ERDVILQELQ ENDTSMRDVV FNYLHATAFQ G TPLAQSVE GPSENVRKLS RADLTEYLSR HYKAPRMVLA AAGGLEHRQL LDLAQKHFSG LSGTYDEDAV PTLTPCRFTG SE IRHREDG LPLAHVAIAV EGPGWANPDN VALQVANAII GHYDCTYGGG MHLSSPLASV AVTNKLCQSF QTFNICYADT GLL GAHFVC DHMSIDDMMF VLQGQWMRLC TSATESEVVR GKNLLRNALV SHLDGTTPVC EDIGRSLLTY GRRIPLAEWE SRIA EVDAR VVREVCSKYF YDQCPAVAGF GPIEQLPDYN RIRSGMFWLR F

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Macromolecule #30: Ubiquinol-cytochrome c reductase core protein 2

MacromoleculeName: Ubiquinol-cytochrome c reductase core protein 2 / type: protein_or_peptide / ID: 30 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 46.655531 KDa
SequenceString: SLKVAPKAKA TAAPAGVPQH PQDLEFTRLP NGLVIASLEN YAPASRIGLF IKAGSRYENF NNLGTSHLLR LASSLTTKGA SSFKITRGI EAVGGKLSVT STRENMAYTV ECLRDDVDIL MEFLLNVTTA PEFRRWEVAA LQSQLRIDKA VAFQNPQAHV I ENLHAAAY ...String:
SLKVAPKAKA TAAPAGVPQH PQDLEFTRLP NGLVIASLEN YAPASRIGLF IKAGSRYENF NNLGTSHLLR LASSLTTKGA SSFKITRGI EAVGGKLSVT STRENMAYTV ECLRDDVDIL MEFLLNVTTA PEFRRWEVAA LQSQLRIDKA VAFQNPQAHV I ENLHAAAY RNALANSLYC PDYRIGKVTP DELHDYVQNH FTSARMALIG LGVSHPVLKQ VAEQFLNIRG GLGLSGAKAK YR GGEIREQ NGDSLVHAAL VAESAAIGSA EANAFSVLQH VLGAGPHVKR GSNATSSLYQ AVAKGVHQPF DVSAFNASYS DSG LFGFYT ISQAASAGDV IKAAYNQVKT IAQGNLSNPD VQAAKNKLKA GYLMSVESSE GFLDEVGCQA LAAGSYTPPS TVLQ QIDAV ADADVINAAK KFVSGRKSMA ASGNLGHTPF IDEL

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Macromolecule #31: Cytochrome b

MacromoleculeName: Cytochrome b / type: protein_or_peptide / ID: 31 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 42.87784 KDa
SequenceString: MINIRKTHPL MKIVNNAFID LPAPSNISSW WNFGSLLGIC LILQILTGLF LAMHYTPDTT TAFSSVTHIC RDVNYGWIIR YMHANGASM FFICLFMHVG RGLYYGSYTF LETWNIGVIL LFATMATAFM GYVLPWGQMS FWGATVITNL LSAIPYIGTN L VEWIWGGF ...String:
MINIRKTHPL MKIVNNAFID LPAPSNISSW WNFGSLLGIC LILQILTGLF LAMHYTPDTT TAFSSVTHIC RDVNYGWIIR YMHANGASM FFICLFMHVG RGLYYGSYTF LETWNIGVIL LFATMATAFM GYVLPWGQMS FWGATVITNL LSAIPYIGTN L VEWIWGGF SVDKATLTRF FAFHFIFPFI IAALAMVHLL FLHETGSNNP TGIPSDTDKI PFHPYYTIKD ILGAILLILI LM LLVLFTP DLLGDPDNYT PANPLNTPPH IKPEWYFLFA YAILRSIPNK LGGVLALVLS ILVLVIMPLL HTSKQRSMMF RPI SQCMFW ILVADLLTLT WIGGQPVEHP YIIIGQLASI MYFLIILVMM PVASIIENNL LKW

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Macromolecule #32: Cytochrome c1

MacromoleculeName: Cytochrome c1 / type: protein_or_peptide / ID: 32 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 27.322316 KDa
SequenceString: SDLELHPPSY PWSHRGLLSS LDHTSIRRGF QVYKQVCSSC HSMDYVAYRH LVGVCYTEDE AKALAEEVEV QDGPNEDGEM FMRPGKLSD YFPKPYPNPE AARAANNGAL PPDLSYIVRA RHGGEDYVFS LLTGYCEPPR VSLREGLYFN PYFPGQAIGM A PPIYNEVL ...String:
SDLELHPPSY PWSHRGLLSS LDHTSIRRGF QVYKQVCSSC HSMDYVAYRH LVGVCYTEDE AKALAEEVEV QDGPNEDGEM FMRPGKLSD YFPKPYPNPE AARAANNGAL PPDLSYIVRA RHGGEDYVFS LLTGYCEPPR VSLREGLYFN PYFPGQAIGM A PPIYNEVL EFDDGTPATM SQVAKDVCTF LRWAAEPEHD HRKRMGLKML LMMGLLLPLV YAMKRHKWSV LKSRKLAYRP PK

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Macromolecule #33: Cytochrome b-c1 complex subunit Rieske, mitochondrial

MacromoleculeName: Cytochrome b-c1 complex subunit Rieske, mitochondrial / type: protein_or_peptide / ID: 33 / Number of copies: 2 / Enantiomer: LEVO / EC number: quinol-cytochrome-c reductase
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 21.654607 KDa
SequenceString: SHTDIKVPDF SDYRRPEVLD STKSSKESSE ARKGFSYLIT ATTTVGVAYA AKNVVSQFVS SMSASADVLA MSKIEIKLSD IPEGKNMAF KWRGKPLFVR HRTKKEIDQE AAVEVSQLRD PQHDLERVKK PEWVILIGVC THLGCVPIAN AGDFGGYYCP C HGSHYDAS ...String:
SHTDIKVPDF SDYRRPEVLD STKSSKESSE ARKGFSYLIT ATTTVGVAYA AKNVVSQFVS SMSASADVLA MSKIEIKLSD IPEGKNMAF KWRGKPLFVR HRTKKEIDQE AAVEVSQLRD PQHDLERVKK PEWVILIGVC THLGCVPIAN AGDFGGYYCP C HGSHYDAS GRIRKGPAPL NLEVPSYEFT SDDMVIVG

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Macromolecule #34: UQCRB

MacromoleculeName: UQCRB / type: protein_or_peptide / ID: 34 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Ovis aries (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 13.432314 KDa
SequenceString:
AGRPAVSASS KWLEGIRKWY YNAAGFNKLG LMRDDTIHEN DDVKEAIRRL PENLYNDRVF RIKRALDLSM RQQILPKEQW TKYEEDKFY LEPYLKEVIR ERKEREEWTK K

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Macromolecule #35: Ubiquinol-cytochrome c reductase complex III subunit VII

MacromoleculeName: Ubiquinol-cytochrome c reductase complex III subunit VII
type: protein_or_peptide / ID: 35 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 9.606067 KDa
SequenceString:
GRQFGHLTRV RHVITYSLSP FEQRAFPHYF SKGIPNVLRR TRACILRVAP PFVVFYLVYT WGTQEFEKSK RKNPAAYEND K

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Macromolecule #36: UQCRQH

MacromoleculeName: UQCRQH / type: protein_or_peptide / ID: 36 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Ovis aries (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 9.223133 KDa
SequenceString:
GDPKEEEEEE EELVDPLTTV REQCEQLEKC VKARERLELC DERVSSRSQT EEDCTEELFD FLHARDHCVA HKLFNSLK

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Macromolecule #37: UQCRFS1N

MacromoleculeName: UQCRFS1N / type: protein_or_peptide / ID: 37 / Details: Modelled as poly-alanine / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Ovis aries (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 6.656196 KDa
SequenceString: (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) ...String:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)

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Macromolecule #38: Ubiquinol-cytochrome c reductase, complex III subunit X

MacromoleculeName: Ubiquinol-cytochrome c reductase, complex III subunit X
type: protein_or_peptide / ID: 38 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 7.310372 KDa
SequenceString:
AAPTLTARLY SLLFRRTSTF ALTIVVGALF FERAFDQGAD AIYEHINEGK LWKHIKHKYE NKE

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Macromolecule #39: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

MacromoleculeName: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
type: protein_or_peptide / ID: 39 / Number of copies: 1 / Enantiomer: LEVO / EC number: NADH dehydrogenase
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 48.678281 KDa
SequenceString: FSGDTTAPKK TSFGSLKDED RIFTNLYGRH DWRLKGAQSR GDWYKTKEIL LKGPDWILGE VKTSGLRGRG GAGFPTGLKW SFMNKPSDG RPKYLVVNAD EGEPGTCKDR EIIRHDPHKL VEGCLVGGRA MGARAAYIYI RGEFYNEASN LQVAIREAYE A GLIGKNAC ...String:
FSGDTTAPKK TSFGSLKDED RIFTNLYGRH DWRLKGAQSR GDWYKTKEIL LKGPDWILGE VKTSGLRGRG GAGFPTGLKW SFMNKPSDG RPKYLVVNAD EGEPGTCKDR EIIRHDPHKL VEGCLVGGRA MGARAAYIYI RGEFYNEASN LQVAIREAYE A GLIGKNAC GSGYDFDVFV VRGAGAYICG EETALIESIE GKQGKPRLKP PFPADVGVFG CPTTVANVET VAVSPTICRR GG AWFASFG RERNSGTKLF NISGHVNNPC TVEEEMSVPL KELIEKHAGG VTGGWDNLLA VIPGGSSTPL IPKSVCETVL MDF DALIQA QTGLGTAAVI VMDRSTDIVK AIARLIEFYK HESCGQCTPC REGVDWMNKV MARFVRGDAR PAEIDSLWEI SKQI EGHTI CALGDGAAWP VQGLIRHFRP ELEERMQRFA QQHQARQAAS

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Macromolecule #40: NDUFV2

MacromoleculeName: NDUFV2 / type: protein_or_peptide / ID: 40 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 23.840428 KDa
SequenceString: GAGGALFVHR DTPKNNPETP FDFTPENYKR IEAIVKNYPE GHKAAAVLPV LDLAQRQNGW LPISAMNKVA EILQVPPMRV YEVATFYTM YNRKPVGKYH IQVCTTTPCM LRNSDSILEA IQKKLGIKVG ETTPDKLFTL IEVECLGACV NAPMVQINDN Y YEDLTPKD ...String:
GAGGALFVHR DTPKNNPETP FDFTPENYKR IEAIVKNYPE GHKAAAVLPV LDLAQRQNGW LPISAMNKVA EILQVPPMRV YEVATFYTM YNRKPVGKYH IQVCTTTPCM LRNSDSILEA IQKKLGIKVG ETTPDKLFTL IEVECLGACV NAPMVQINDN Y YEDLTPKD IEEIIDELKA GKIPKPGPRS GRFSCEPAGG LTSLTEPPKG PGFGVQAGL

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Macromolecule #41: NADH:ubiquinone oxidoreductase core subunit S1

MacromoleculeName: NADH:ubiquinone oxidoreductase core subunit S1 / type: protein_or_peptide / ID: 41 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 77.031156 KDa
SequenceString: TATAASNLIE VFVDGQSVMV EPGTTVLQAC EKVGMQIPRF CYHERLSVAG NCRMCLVEIE KAPKVVAACA MPVMKGWNIL TNSEKTKKA REGVMEFLLA NHPLDCPICD QGGECDLQDQ SMMFGSDRSR FLEGKRAVED KNIGPLVKTI MTRCIQCTRC I RFASEIAG ...String:
TATAASNLIE VFVDGQSVMV EPGTTVLQAC EKVGMQIPRF CYHERLSVAG NCRMCLVEIE KAPKVVAACA MPVMKGWNIL TNSEKTKKA REGVMEFLLA NHPLDCPICD QGGECDLQDQ SMMFGSDRSR FLEGKRAVED KNIGPLVKTI MTRCIQCTRC I RFASEIAG VDDLGTTGRG NDMQVGTYIE KMFMSELSGN IIDICPVGAL TSKPYAFTAR PWETRKTESI DVMDAVGSNI VV STRTGEV MRILPRMHED INEEWISDKT RFAYDGLKRQ RLTEPMVRNE KGLLTHTTWE DALSRVAGML QSCQGNDVAA IAG GLVDAE ALIALKDLLN RVDSDTLCTE EVFPTAGAGT DLRSNYLLNT TIAGVEEADV VLLVGTNPRF EAPLFNARIR KSWL HNDLK VALIGSPVDL TYRYDHLGDS PKILQDIASG SHPFSQVLQE AKKPMVVLGS SALQRNDGAA ILAAVSNIAQ KIRTS SGVT GDWKVMNILH RIASQVAALD LGYKPGVEAI RKNPPKMLFL LGADGGCVTR QDLPKDCFIV YQGHHGDVGA PIADVI LPG AAYTEKSATY VNTEGRAQQT KVAVMPPGLA REDWKIIRAL SEIAGMTLPY DTLDQVRNRL EEVSPNLVRY DDVEGAN YF QQASELSKLV NQQLLADPLV PPQLTIKDFY MTDSISRASQ TMAKCVKAVT EGAHAVEEPS IC

+
Macromolecule #42: NDUFS2

MacromoleculeName: NDUFS2 / type: protein_or_peptide / ID: 42 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Ovis aries (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 49.193273 KDa
SequenceString: ARQWQPDVEW AEQYGGAVMY PTKETAHWKP PPWNDVDPPK DTLVSNLTLN FGPQHPAAHG VLRLVMELSG EMVRKCDPHI GLLHRGTEK LIEYKTYLQA LPYFDRLDYV SMMCNEQAYS LAVEKLLNIQ PPPRAQWIRV LFGEITRLLN HIMAVTTHAL D IGAMTPFF ...String:
ARQWQPDVEW AEQYGGAVMY PTKETAHWKP PPWNDVDPPK DTLVSNLTLN FGPQHPAAHG VLRLVMELSG EMVRKCDPHI GLLHRGTEK LIEYKTYLQA LPYFDRLDYV SMMCNEQAYS LAVEKLLNIQ PPPRAQWIRV LFGEITRLLN HIMAVTTHAL D IGAMTPFF WMFEEREKMF EFYERVSGAR MHAAYVRPGG VHQDLPLGLM DDIYEFSKNF SLRIDELEEM LTNNRIWRNR TV DIGVVTA EDALNYGFSG VMLRGSGIQW DLRKTQPYDV YDQVEFDVPI GSRGDCYDRY LCRVEEMRQS IRIISQCLNK MPP GEIKVD DAKVSPPKRA EMKTSMESLI HHFKLYTEGY QVPPGATYTA IEAPKGEFGV YLVSDGSSRP YRCKIKAPGF AHLA GLDKM SKGHMLADVV AIIGTQDIVF GEVDR

+
Macromolecule #43: NADH:ubiquinone oxidoreductase core subunit S3

MacromoleculeName: NADH:ubiquinone oxidoreductase core subunit S3 / type: protein_or_peptide / ID: 43 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 26.441793 KDa
SequenceString: ESASADTRPT VRPRNDVAHK QLSAFGEYVA EILPKYVQQV QVSCFSELEI CIHPDGVIPV LTFLRDHSNA QFKSLADLTA VDIPTRQNR FEIVYNLLSL RFNSRIRVKT YTDELTPVES SVSVYKAANW YEREIWDMFG VFFANHPDLR RILTDYGFEG H PFRKDFPL ...String:
ESASADTRPT VRPRNDVAHK QLSAFGEYVA EILPKYVQQV QVSCFSELEI CIHPDGVIPV LTFLRDHSNA QFKSLADLTA VDIPTRQNR FEIVYNLLSL RFNSRIRVKT YTDELTPVES SVSVYKAANW YEREIWDMFG VFFANHPDLR RILTDYGFEG H PFRKDFPL SGYVELRYDD EVKRVVAEPV ELAQEFRKFD LNSPWEAFPA YRQPPESLKL EAGDKKPEAK

+
Macromolecule #44: NDUFS7

MacromoleculeName: NDUFS7 / type: protein_or_peptide / ID: 44 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Ovis aries (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 20.104531 KDa
SequenceString:
PSSTQPAVSQ ARAVVPKPAA LPSSRGEYVV AKLDDLINWA RRSSLWPMTF GLACCAVEMM HMAAPRYDMD RFGVVFRASP RQSDVMIVA GTLTNKMAPA LRKVYDQMPE PRYVVSMGSC ANGGGYYHYS YSVVRGCDRI VPVDIYVPGC PPTAEALLYG I LQLQKKIK REKRLRIWYR R

+
Macromolecule #45: NDUFS8

MacromoleculeName: NDUFS8 / type: protein_or_peptide / ID: 45 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Ovis aries (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 20.219947 KDa
SequenceString:
TYKYVNLREP SMDMKSVTDR AAQTLLWTEL IRGLGMTLSY LFREPATINY PFEKGPLSPR FRGEHALRRY PSGEERCIAC KLCEAVCPA QAITIEAEPR ADGSRRTTRY DIDMTKCIYC GFCQEACPVD AIVEGPNFEF STETHEELLY NKEKLLNNGD K WEAEIAAN IQADYLYR

+
Macromolecule #46: NDUFV3

MacromoleculeName: NDUFV3 / type: protein_or_peptide / ID: 46 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Ovis aries (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 8.423314 KDa
SequenceString:
SAESGKNEKG LPPNPKKQSP PKKPASAAPT EPFDNTTYKN LQHHDYSTYT FLDLNLDLSK FRMPQPSSGR ESPRH

+
Macromolecule #47: NDUFS6

MacromoleculeName: NDUFS6 / type: protein_or_peptide / ID: 47 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Ovis aries (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 10.651796 KDa
SequenceString:
GVRTSPTGEK VTHTGQVYDD EDYRRVRFVG RQKEVNENFA IDLIAEQPVS QVGSRVISCD GGGGALGHPR VYINLDKETK TGTCGYCGL QFRQQHH

+
Macromolecule #48: NADH:ubiquinone oxidoreductase subunit S4

MacromoleculeName: NADH:ubiquinone oxidoreductase subunit S4 / type: protein_or_peptide / ID: 48 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 15.3753 KDa
SequenceString:
AQDQTRDTQL ITVDEKLDIT TLTGVPEEHI KTRKARIFVP ARNNMQSGVN NTKKWKMEFD TRERWENPLM GWASTADPLS NLVLTFSTK EDAIAFAEKN GWSYDVEERK VPKPKSKSYG ANFSWNKRTR VSTK

+
Macromolecule #49: NADH:ubiquinone oxidoreductase subunit A9

MacromoleculeName: NADH:ubiquinone oxidoreductase subunit A9 / type: protein_or_peptide / ID: 49 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 38.660488 KDa
SequenceString: LHHAVIPHGK GGRSSVSGIV ATVFGATGFL GRYLVNHLGR MGSQVIVPYR CEPYDTMHLR PMGDLGQIIF MDWNGRDKDS IRRAVEHSN VVINLVGREW ETKNFDFEDV FVKIPQAIAQ VSKEAGVEKF IHISHLNADI KSSSKYLRNK AVGEKEVRET F PEATIIKP ...String:
LHHAVIPHGK GGRSSVSGIV ATVFGATGFL GRYLVNHLGR MGSQVIVPYR CEPYDTMHLR PMGDLGQIIF MDWNGRDKDS IRRAVEHSN VVINLVGREW ETKNFDFEDV FVKIPQAIAQ VSKEAGVEKF IHISHLNADI KSSSKYLRNK AVGEKEVRET F PEATIIKP ADIFGREDRF LNYFANIRWF GGVPLISLGK KTVKQPVYIV DVTKGIINAI KDPDARGKTF AFVGPNRYLL FD LVQYVFA VAHRPFLPYP MPHFAYRWIG RLFEISPFEP WTTRDKVERI HTTDRTLPHL PGLEDLGVQA TPLELKAIEV LRR HRTYRW LSSEIEDVQP AK

+
Macromolecule #50: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

MacromoleculeName: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
type: protein_or_peptide / ID: 50 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 10.966627 KDa
SequenceString:
AAAAAIRGVR GKLGLREIRI HLCQRSPGSQ GVRDFIEKRY VELKKANPDL PILIRECSDV QPKLWARYAF GQEKNVSLNN FSADQVTRA LENVLSSKA

+
Macromolecule #51: NDUFA5

MacromoleculeName: NDUFA5 / type: protein_or_peptide / ID: 51 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 13.156311 KDa
SequenceString:
AGLLKKTTGL VGLAVCETPH ERLKILYTKI LDVLGHIPKN AAYRKYTEQI TNEKLSIVKA EPDVKKLEEQ LQGGQIEEVI LQAENELSL ARKMIQWKPW EPLVEEPPAS QWKWPI

+
Macromolecule #52: NADH:ubiquinone oxidoreductase subunit A6

MacromoleculeName: NADH:ubiquinone oxidoreductase subunit A6 / type: protein_or_peptide / ID: 52 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 14.923245 KDa
SequenceString:
AASGLRQAAV AASTSVKPIF SRDMNEAKRR VRELYRAWYR EVPNTVHLFQ LDISVKQGRD KVREMFKKNA HVTDPRVVDL LVIKGKMEL EETINVWKQR THVMRFFHET EAPRPKDFLS KFYVGHDP

+
Macromolecule #53: NDUFA7

MacromoleculeName: NDUFA7 / type: protein_or_peptide / ID: 53 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 12.399201 KDa
SequenceString:
ASATRLIQGL RNWASGRDLQ AKLQLRYQEI SKRTQPPPKL PVGPSHRLSN NYYCARDGRR EAMPPSIVMS SQKVLVAGKP AESSAVAAS EKKAVSPAPP IKRWELSQDE PYL

+
Macromolecule #54: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

MacromoleculeName: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
type: protein_or_peptide / ID: 54 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sheep (sheep) / Organ: heart / Tissue: heart
Molecular weightTheoretical: 17.115508 KDa
SequenceString:
MELLQVLKRG LQQVSGHGGL RGYLRVLFRA NDVRVGTLVG EDKYGNKYYE DNKQFFGRHR WVIYTTEMNG KNTFWDVDGS MVPPEWHRW LHCMTDDPPT VKPPTARKFI WTNHKFNLSG TPQQYVPYST TRKKIQEWVP PSTPYK

+
Macromolecule #55: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE

MacromoleculeName: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE / type: ligand / ID: 55 / Number of copies: 5 / Formula: 3PE
Molecular weightTheoretical: 748.065 Da

+
Macromolecule #56: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE

MacromoleculeName: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE / type: ligand / ID: 56 / Number of copies: 1 / Formula: PC1
Molecular weightTheoretical: 790.145 Da
Chemical component information

ChemComp-PC1:
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE / phospholipid*YM

+
Macromolecule #57: S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-b...

MacromoleculeName: S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate
type: ligand / ID: 57 / Number of copies: 2 / Formula: ZMP
Molecular weightTheoretical: 568.704 Da
Chemical component information

ChemComp-ZMP:
S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate

+
Macromolecule #58: PROTOPORPHYRIN IX CONTAINING FE

MacromoleculeName: PROTOPORPHYRIN IX CONTAINING FE / type: ligand / ID: 58 / Number of copies: 4 / Formula: HEM
Molecular weightTheoretical: 616.487 Da
Chemical component information

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

+
Macromolecule #59: HEME C

MacromoleculeName: HEME C / type: ligand / ID: 59 / Number of copies: 2 / Formula: HEC
Molecular weightTheoretical: 618.503 Da
Chemical component information

ChemComp-HEC:
HEME C

+
Macromolecule #60: FE2/S2 (INORGANIC) CLUSTER

MacromoleculeName: FE2/S2 (INORGANIC) CLUSTER / type: ligand / ID: 60 / Number of copies: 4 / Formula: FES
Molecular weightTheoretical: 175.82 Da
Chemical component information

ChemComp-FES:
FE2/S2 (INORGANIC) CLUSTER

+
Macromolecule #61: CARDIOLIPIN

MacromoleculeName: CARDIOLIPIN / type: ligand / ID: 61 / Number of copies: 3 / Formula: CDL
Molecular weightTheoretical: 1.464043 KDa
Chemical component information

ChemComp-CDL:
CARDIOLIPIN / phospholipid*YM

+
Macromolecule #62: IRON/SULFUR CLUSTER

MacromoleculeName: IRON/SULFUR CLUSTER / type: ligand / ID: 62 / Number of copies: 6 / Formula: SF4
Molecular weightTheoretical: 351.64 Da
Chemical component information

ChemComp-FS1:
IRON/SULFUR CLUSTER

+
Macromolecule #63: FLAVIN MONONUCLEOTIDE

MacromoleculeName: FLAVIN MONONUCLEOTIDE / type: ligand / ID: 63 / Number of copies: 1 / Formula: FMN
Molecular weightTheoretical: 456.344 Da
Chemical component information

ChemComp-FMN:
FLAVIN MONONUCLEOTIDE

+
Macromolecule #64: ZINC ION

MacromoleculeName: ZINC ION / type: ligand / ID: 64 / Number of copies: 1 / Formula: ZN
Molecular weightTheoretical: 65.409 Da

+
Macromolecule #65: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

MacromoleculeName: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
type: ligand / ID: 65 / Number of copies: 1 / Formula: NDP
Molecular weightTheoretical: 745.421 Da
Chemical component information

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

-
Experimental details

-
Structure determination

Methodcryo EM
Processingsingle particle reconstruction
Aggregation stateparticle

-
Sample preparation

Concentration2 mg/mL
BufferpH: 7.4
Component:
ConcentrationFormulaName
0.25 MNaClsodium chloride
0.02 MHEPES
0.02 %Brij-35

Details: 250 mM NaCl, 20 mM HEPES, pH 7.7, 0.02% Brij-35
VitrificationCryogen name: PROPANE / Chamber humidity: 95 % / Chamber temperature: 277 K / Instrument: FEI VITROBOT MARK IV
Details: blotting for 30 seconds at 4 degrees Celsius, 95% humidity and flash freezing.

-
Electron microscopy

MicroscopeFEI TITAN KRIOS
Image recordingFilm or detector model: FEI FALCON II (4k x 4k) / Number grids imaged: 1 / Number real images: 1854 / Average exposure time: 2.0 sec. / Average electron dose: 51.0 e/Å2
Electron beamAcceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
Electron opticsCalibrated defocus max: 3.0 µm / Calibrated defocus min: 1.5 µm / Calibrated magnification: 100000 / Illumination mode: OTHER / Imaging mode: BRIGHT FIELD
Sample stageSpecimen holder model: FEI TITAN KRIOS AUTOGRID HOLDER / Cooling holder cryogen: NITROGEN
Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company

+
Image processing

Particle selectionNumber selected: 400000
CTF correctionSoftware - Name: Gctf
Startup modelType of model: PDB ENTRY
PDB model - PDB ID:

5lnk

Final reconstructionNumber classes used: 1 / Applied symmetry - Point group: C1 (asymmetric) / Resolution.type: BY AUTHOR / Resolution: 4.2 Å / Resolution method: FSC 0.143 CUT-OFF / Software - Name: RELION (ver. 2) / Number images used: 30836
Initial angle assignmentType: MAXIMUM LIKELIHOOD / Software - Name: RELION (ver. 2)
Final angle assignmentType: MAXIMUM LIKELIHOOD / Software - Name: RELION (ver. 2)
Final 3D classificationNumber classes: 3 / Software - Name: RELION (ver. 2)
FSC plot (resolution estimation)

-
Atomic model buiding 1

Initial model(PDB ID:

1ppj

,

5lnk

)
RefinementSpace: REAL / Protocol: OTHER / Overall B value: 90
Output model

PDB-6qc2:
Ovine respiratory supercomplex I+III2 open class 2

+
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