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- EMDB-40968: Atomic model of the mammalian Mediator complex with MED26 subunit -

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基本情報

登録情報
データベース: EMDB / ID: EMD-40968
タイトルAtomic model of the mammalian Mediator complex with MED26 subunit
マップデータAtomic model of the mammalian Mediator complex with MED26 subunit
試料
  • 複合体: Mouse mediator complex
    • タンパク質・ペプチド: x 27種
キーワードmouse mediator / complex / GENE REGULATION / MED26 subunit
機能・相同性
機能・相同性情報


positive regulation of T cell extravasation / Nuclear Receptor transcription pathway / negative regulation of smooth muscle cell differentiation / enucleate erythrocyte development / positive regulation of type II interferon-mediated signaling pathway / regulation of RNA biosynthetic process / androgen biosynthetic process / positive regulation of G0 to G1 transition / retinal pigment epithelium development / mammary gland branching involved in thelarche ...positive regulation of T cell extravasation / Nuclear Receptor transcription pathway / negative regulation of smooth muscle cell differentiation / enucleate erythrocyte development / positive regulation of type II interferon-mediated signaling pathway / regulation of RNA biosynthetic process / androgen biosynthetic process / positive regulation of G0 to G1 transition / retinal pigment epithelium development / mammary gland branching involved in thelarche / G0 to G1 transition / thyroid hormone receptor signaling pathway / Regulation of lipid metabolism by PPARalpha / core mediator complex / Cytoprotection by HMOX1 / regulation of vitamin D receptor signaling pathway / Estrogen-dependent gene expression / LBD domain binding / ventricular trabecula myocardium morphogenesis / thyroid hormone generation / mediator complex / nuclear retinoic acid receptor binding / positive regulation of keratinocyte differentiation / embryonic heart tube development / camera-type eye development / cellular response to thyroid hormone stimulus / monocyte differentiation / positive regulation of hepatocyte proliferation / embryonic hindlimb morphogenesis / peroxisome proliferator activated receptor binding / nuclear vitamin D receptor binding / limb development / lens development in camera-type eye / nuclear thyroid hormone receptor binding / positive regulation of intracellular estrogen receptor signaling pathway / embryonic hemopoiesis / mammary gland epithelial cell proliferation / embryonic placenta development / megakaryocyte development / histone acetyltransferase binding / cellular response to hepatocyte growth factor stimulus / termination of RNA polymerase II transcription / cortical actin cytoskeleton / epithelial cell proliferation involved in mammary gland duct elongation / fat cell differentiation / skeletal muscle cell differentiation / mammary gland branching involved in pregnancy / somatic stem cell population maintenance / nuclear retinoid X receptor binding / blastocyst development / general transcription initiation factor binding / cellular response to epidermal growth factor stimulus / negative regulation of neuron differentiation / hematopoietic stem cell differentiation / negative regulation of keratinocyte proliferation / positive regulation of transcription initiation by RNA polymerase II / peroxisome proliferator activated receptor signaling pathway / animal organ regeneration / erythrocyte development / positive regulation of transcription elongation by RNA polymerase II / nuclear receptor-mediated steroid hormone signaling pathway / ubiquitin ligase complex / negative regulation of fibroblast proliferation / RNA polymerase II preinitiation complex assembly / histone acetyltransferase activity / keratinocyte differentiation / transcription coregulator activity / lactation / positive regulation of erythrocyte differentiation / liver development / nuclear receptor coactivator activity / mRNA transcription by RNA polymerase II / nuclear receptor binding / promoter-specific chromatin binding / nuclear estrogen receptor binding / protein-DNA complex / animal organ morphogenesis / brain development / cell morphogenesis / chromatin DNA binding / transcription coactivator binding / protein import into nucleus / transcription corepressor activity / ubiquitin protein ligase activity / heart development / actin binding / transcription regulator complex / angiogenesis / transcription coactivator activity / in utero embryonic development / RNA polymerase II-specific DNA-binding transcription factor binding / transcription by RNA polymerase II / cytoskeleton / nuclear body / protein ubiquitination / RNA polymerase II cis-regulatory region sequence-specific DNA binding / chromatin binding / positive regulation of cell population proliferation / regulation of transcription by RNA polymerase II / positive regulation of gene expression
類似検索 - 分子機能
Mediator complex subunit 26, C-terminal domain / Mediator complex subunit 26, middle domain / Mediator of RNA polymerase II transcription subunit 26 / Mediator complex subunit 26 C-terminal / Mediator complex subunit 26 middle domain / Mediator complex, subunit Med25, PTOV domain / Mediator complex, subunit Med25, synapsin 1 / Mediator of RNA polymerase II transcription subunit 25, von Willebrand factor type A domain / Mediator complex subunit 25, PTOV domain superfamily / Mediator complex subunit 25 PTOV activation and synapsin 2 ...Mediator complex subunit 26, C-terminal domain / Mediator complex subunit 26, middle domain / Mediator of RNA polymerase II transcription subunit 26 / Mediator complex subunit 26 C-terminal / Mediator complex subunit 26 middle domain / Mediator complex, subunit Med25, PTOV domain / Mediator complex, subunit Med25, synapsin 1 / Mediator of RNA polymerase II transcription subunit 25, von Willebrand factor type A domain / Mediator complex subunit 25, PTOV domain superfamily / Mediator complex subunit 25 PTOV activation and synapsin 2 / Mediator complex subunit 25 synapsin 1 / Mediator complex subunit 25 von Willebrand factor type A / Mediator complex, subunit Med19, metazoa / Mediator of RNA pol II transcription subunit 19 / Mediator complex, subunit Med29, metazoa / Mediator complex, subunit Med24, / : / Mediator complex subunit 24 N-terminal / Mediator complex subunit 29 / Mediator complex subunit 16, central helical bridge / Mediator complex, subunit Med23 / Mediator complex subunit 23 / Mediator of RNA polymerase II transcription subunit 15 / : / : / ARC105/Med15 mediator subunit N-terminal KIX domain / ARC105/Med15 mediator subunit central domain / ARC105/Med15 mediator subunit C-terminal domain / Mediator complex, subunit Med6, metazoa/plant / Mediator complex, subunit Med30, metazoa / Mediator complex, subunit Med28 / Mediator of RNA polymerase II transcription subunit 9, metazoan / Mediator complex subunit 30 / Mediator complex subunit 28 / Mediator complex, subunit Med27 / Mediator complex subunit 27 / : / : / Mediator complex subunit 16, C-terminal / Mediator complex, subunit Med16 / Mediator complex subunit 16, N-terminal / : / Mediator complex, subunit Med10 / Transcription factor subunit Med10 of Mediator complex / Mediator of RNA polymerase II transcription subunit 9 / RNA polymerase II transcription mediator complex subunit 9 / Mediator complex, subunit Med4 / Vitamin-D-receptor interacting Mediator subunit 4 / Mediator complex, subunit Med31 / Mediator complex, subunit Med21 / Mediator of RNA polymerase II, subunit Med31 superfamily / Mediator complex, subunit Med7 superfmaily / SOH1 / Subunit 21 of Mediator complex / Mediator complex, subunit Med7 / Mediator complex, subunit Med7/Med21-like / MED7 protein / Mediator complex, subunit Med20 / Mediator complex, subunit Med14 / TATA-binding related factor (TRF) of subunit 20 of Mediator complex / Mediator complex subunit MED14 / Soluble quinoprotein glucose/sorbosone dehydrogenase / Mediator complex, subunit Med6 / Mediator complex, subunit Med17 / Mediator complex, subunit Med6 superfamily / MED6 mediator sub complex component / Subunit 17 of Mediator complex / Mediator of RNA polymerase II transcription subunit 22 / Mediator complex, subunit Med8, fungi/metazoa / Mediator complex, subunit Med11 / Surfeit locus protein 5 subunit 22 of Mediator complex / Mediator of RNA polymerase II transcription complex subunit 8 / Mediator complex protein / Mediator complex, subunit Med18 / Med18 protein / Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type / Domain in the N-terminus of transcription elongation factor S-II (and elsewhere) / : / Mediator complex, subunit Med1 / Mediator of RNA polymerase II transcription subunit 1 / TFIIS helical bundle-like domain / Transcription factor IIS, N-terminal / TFIIS N-terminal domain profile. / TFIIS/LEDGF domain superfamily / Coactivator CBP, KIX domain superfamily / von Willebrand factor A-like domain superfamily / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily
類似検索 - ドメイン・相同性
Mediator of RNA polymerase II transcription subunit 14 / Mediator of RNA polymerase II transcription subunit 22 / Mediator of RNA polymerase II transcription subunit 16 / Mediator of RNA polymerase II transcription subunit 26 / Mediator of RNA polymerase II transcription subunit 23 / Mediator of RNA polymerase II transcription subunit 19 / Mediator of RNA polymerase II transcription subunit 25 / Mediator of RNA polymerase II transcription subunit 17 / Mediator of RNA polymerase II transcription subunit 9 / Mediator of RNA polymerase II transcription subunit 28 ...Mediator of RNA polymerase II transcription subunit 14 / Mediator of RNA polymerase II transcription subunit 22 / Mediator of RNA polymerase II transcription subunit 16 / Mediator of RNA polymerase II transcription subunit 26 / Mediator of RNA polymerase II transcription subunit 23 / Mediator of RNA polymerase II transcription subunit 19 / Mediator of RNA polymerase II transcription subunit 25 / Mediator of RNA polymerase II transcription subunit 17 / Mediator of RNA polymerase II transcription subunit 9 / Mediator of RNA polymerase II transcription subunit 28 / Mediator of RNA polymerase II transcription subunit 6 / Mediator of RNA polymerase II transcription subunit 15 / Mediator of RNA polymerase II transcription subunit 1 / Mediator of RNA polymerase II transcription subunit 24 / Mediator of RNA polymerase II transcription subunit 21 / Mediator of RNA polymerase II transcription subunit 4 / Mediator of RNA polymerase II transcription subunit 30 / Mediator of RNA polymerase II transcription subunit 10 / Mediator of RNA polymerase II transcription subunit 31 / Mediator of RNA polymerase II transcription subunit 18 / Mediator of RNA polymerase II transcription subunit 7 / Mediator of RNA polymerase II transcription subunit 8 / Mediator of RNA polymerase II transcription subunit 11 / Mediator of RNA polymerase II transcription subunit 27 / Mediator of RNA polymerase II transcription subunit 29 / Mediator of RNA polymerase II transcription subunit 20
類似検索 - 構成要素
生物種Mus musculus (ハツカネズミ)
手法単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 4.68 Å
データ登録者Zhao H / Asturias F
資金援助 米国, 2件
OrganizationGrant number国
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)R01-67167 米国
National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS) 米国
引用ジャーナル: Mol Cell / 年: 2024
タイトル: An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II.
著者: Haiyan Zhao / Jiaqin Li / Yufei Xiang / Sohail Malik / Supriya V Vartak / Giovana M B Veronezi / Natalie Young / McKayla Riney / Jens Kalchschmidt / Andrea Conte / Seol Kyoung Jung / Srinivas ...著者: Haiyan Zhao / Jiaqin Li / Yufei Xiang / Sohail Malik / Supriya V Vartak / Giovana M B Veronezi / Natalie Young / McKayla Riney / Jens Kalchschmidt / Andrea Conte / Seol Kyoung Jung / Srinivas Ramachandran / Robert G Roeder / Yi Shi / Rafael Casellas / Francisco J Asturias /
要旨: The essential Mediator (MED) coactivator complex plays a well-understood role in regulation of basal transcription in all eukaryotes, but the mechanism underlying its role in activator-dependent ...The essential Mediator (MED) coactivator complex plays a well-understood role in regulation of basal transcription in all eukaryotes, but the mechanism underlying its role in activator-dependent transcription remains unknown. We investigated modulation of metazoan MED interaction with RNA polymerase II (RNA Pol II) by antagonistic effects of the MED26 subunit and the CDK8 kinase module (CKM). Biochemical analysis of CKM-MED showed that the CKM blocks binding of the RNA Pol II carboxy-terminal domain (CTD), preventing RNA Pol II interaction. This restriction is eliminated by nuclear receptor (NR) binding to CKM-MED, which enables CTD binding in a MED26-dependent manner. Cryoelectron microscopy (cryo-EM) and crosslinking-mass spectrometry (XL-MS) revealed that the structural basis for modulation of CTD interaction with MED relates to a large intrinsically disordered region (IDR) in CKM subunit MED13 that blocks MED26 and CTD interaction with MED but is repositioned upon NR binding. Hence, NRs can control transcription initiation by priming CKM-MED for MED26-dependent RNA Pol II interaction.
履歴
登録2023年6月2日-
ヘッダ(付随情報) 公開2024年6月12日-
マップ公開2024年6月12日-
更新2024年8月7日-
現状2024年8月7日処理サイト: RCSB / 状態: 公開

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構造の表示

添付画像

emd_40968.png

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マップ

ファイルダウンロード / ファイル: emd_40968.map.gz / 形式: CCP4 / 大きさ: 669.9 MB / タイプ: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
注釈Atomic model of the mammalian Mediator complex with MED26 subunit
ボクセルのサイズX=Y=Z: 1.11 Å
密度
表面レベル登録者による: 0.054
最小 - 最大-0.070911705 - 0.30787417
平均 (標準偏差)-0.00021929563 (±0.008145886)
対称性空間群: 1
詳細

EMDB XML:

マップ形状
Axis orderXYZ
Origin000
サイズ560560560
Spacing560560560
セルA=B=C: 621.60004 Å
α=β=γ: 90.0 °

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添付データ

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ハーフマップ: Half Map 1

ファイルemd_40968_half_map_1.map
注釈Half Map 1
投影像・断面図
軸ZYX

投影像

断面 (1/2)
密度ヒストグラム

ヒストグラム

ヒストグラム (対数)

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ハーフマップ: Half Map 2

ファイルemd_40968_half_map_2.map
注釈Half Map 2
投影像・断面図
軸ZYX

投影像

断面 (1/2)
密度ヒストグラム

ヒストグラム

ヒストグラム (対数)

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試料の構成要素

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全体 : Mouse mediator complex

全体名称: Mouse mediator complex
要素
  • 複合体: Mouse mediator complex
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 1
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 4
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 6
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 7
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 8
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 9
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 10
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 11
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 14
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 15
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 16
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 17
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 18
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 19
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 20
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 21
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 22
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 23
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 24
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 25
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 26
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 27
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 28
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 29
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 30
    • タンパク質・ペプチド: Mediator of RNA polymerase II transcription subunit 31
    • タンパク質・ペプチド: Unknown Peptide

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超分子 #1: Mouse mediator complex

超分子名称: Mouse mediator complex / タイプ: complex / ID: 1 / 親要素: 0 / 含まれる分子: all
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 1.0 MDa

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分子 #1: Mediator of RNA polymerase II transcription subunit 1

分子名称: Mediator of RNA polymerase II transcription subunit 1
タイプ: protein_or_peptide / ID: 1 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 167.354859 KDa
配列文字列: MKAQGETEDS ERLSKMSSLL ERLHAKFNQN RPWSETIKLV RQVMEKRVVM SSGGHQHLVS CLETLQKALK VTSLPAMTDR LESIARQNG LGSHLSASGT ECYITSDMFY VEVQLDPAGQ LCDVKVAHHG ENPVSCPELV QQLREKNFEE FSKHLKGLVN L YNLPGDNK ...文字列:
MKAQGETEDS ERLSKMSSLL ERLHAKFNQN RPWSETIKLV RQVMEKRVVM SSGGHQHLVS CLETLQKALK VTSLPAMTDR LESIARQNG LGSHLSASGT ECYITSDMFY VEVQLDPAGQ LCDVKVAHHG ENPVSCPELV QQLREKNFEE FSKHLKGLVN L YNLPGDNK LKTKMYLALQ SLEQDLSKMA IMYWKATNAA PLDKILHGSV GYLTPRSGGH LMNMKYYASP SDLLDDKTAS PI ILHEKNV PRSLGMNASV TIEGTSAMYK LPIAPLIMGS HPADNKWTPS FSAVTSANSV DLPACFFLKF PQPIPVSKAF VQK LQNCTG IPLFETPPTY LPLYELITQF ELSKDPDPLP LNHNMRFYAA LPGQQHCYFL NKDAPLPDGQ SLQGTLVSKI TFQH PGRVP LILNMIRHQV AYNTLIGSCV KRTILKEDSP GLLQFEVCPL SESRFSVSFQ HPVNDSLVCV VMDVQDSTHV SCKLY KGLS DALICTDDFI AKVVQRCMSI PVTMRAIRRK AETIQADTPA LSLIAETVED MVKKNLPPAS SPGYGMTTGN NPMSGT TTP TNTFPGGPIT TLFNMSMSIK DRHESVGHGE DFSKVSQNPI LTSLLQITGN GGSTIGSSPT PPHHTPPPVS SMAGNTK NH PMLMNLLKDN PAQDFSTLYG SSPLERQNSS SGSPRMEMCS GSNKAKKKKS SRVPPDKPKH QTEDDFQREL FSMDVDSQ N PMFDVSMTAD ALDTPHITPA PSQCSTPPAT YPQPVSHPQP SIQRMVRLSS SDSIGPDVTD ILSDIAEEAS KLPSTSDDC PPIGTPVRDS SSSGHSQSAL FDSDVFQTNN NENPYTDPAD LIADAAGSPN SDSPTNHFFP DGVDFNPDLL NSQSQSGFGE EYFDESSQS GDNDDFKGFA SQALNTLGMP MLGGDNGEPK FKGSSQADTV DFSIISVAGK ALGAADLMEH HSGSQSPLLT T GELGKEKT QKRVKEGNGT GASSGSGPGS DSKPGKRSRT PSNDGKSKDK PPKRKKADTE GKSPSHSSSN RPFTPPTSTG GS KSPGSSG RSQTPPGVAT PPIPKITIQI PKGTVMVGKP SSHSQYTSSG SVSSSGSKSH HSHSSSSSSL ASASTSGKVK SSK SEGSSS SKLSGSMYAS QGSSGSSQSK NSSQTGGKPG SSPITKHGLS SGSSSTKMKP QGKPSSLMNP SISKPNISPS HSRP PGGSD KLASPMKPVP GTPPSSKAKS PISSGSSGSH VSGTSSSSGM KSSSGSASSG SVSQKTPPAS NSCTPSSSSF SSSGS SMSS SQNQHGSSKG KSPSRNKKPS LTAVIDKLKH GVVTSGPGGE DPIDSQMGAS TNSSNHPMSS KHNTSGGEFQ SKREKS DKD KSKVSASGGS VDSSKKTSES KNVGSTGVAK IIISKHDGGS PSIKAKVTLQ KPGESGGDGL RPQIASSKNY GSPLISG ST PKHERGSPSH SKSPAYTPQN VDSESESGSS IAERSYQNSP SSEDGIRPLP EYSTEKHKKH KKEKKKVRDK DRDKKKSH S MKPENWSKSP ISSDPTASVT NNPILSADRP SRLSPDFMIG EEDDDLMDVA LIGN

UniProtKB: Mediator of RNA polymerase II transcription subunit 1

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分子 #2: Mediator of RNA polymerase II transcription subunit 4

分子名称: Mediator of RNA polymerase II transcription subunit 4
タイプ: protein_or_peptide / ID: 2 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 29.817475 KDa
配列文字列: MAASSSGEKE KERMGGVSGM AGLGSTRERL LSALEDLEVL SRELIEMLAI SRNQKLLQLE EENQVLELLI HRDGDFQELM KLALNQGKV HHEMQALEKE VEKRDSDIQQ LQKQLKEAEQ ILATAVYQAK EKLKSIEKAR KGAISSEEII KYAHRISASN A VCAPLTWV ...文字列:
MAASSSGEKE KERMGGVSGM AGLGSTRERL LSALEDLEVL SRELIEMLAI SRNQKLLQLE EENQVLELLI HRDGDFQELM KLALNQGKV HHEMQALEKE VEKRDSDIQQ LQKQLKEAEQ ILATAVYQAK EKLKSIEKAR KGAISSEEII KYAHRISASN A VCAPLTWV PGDPRRPYPT DLEMRSGLLG QMNNPSTSGV NGHLPGDALA AGRLPDVLAP QYPWQSNDMS VNMLPPNHSS DF LLEPPGH NKENEDDVEV MSTDSSSSSS DSD

UniProtKB: Mediator of RNA polymerase II transcription subunit 4

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分子 #3: Mediator of RNA polymerase II transcription subunit 6

分子名称: Mediator of RNA polymerase II transcription subunit 6
タイプ: protein_or_peptide / ID: 3 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 28.473553 KDa
配列文字列: MAAVDIRDNL LGISWVDSSW IPILNSGSVL DYFSERSNPF YDRTCNNEVV KMQRLTLEHL NQMVGIEYIL LHAQEPILFI IRKQQRQSP AQVIPLADYY IIAGVIYQAP DLGSVINSRV LTAVHGIQSA FDEAMSYCRY HPSKGYWWHF KDHEEQEKVK P KAKRKEEP ...文字列:
MAAVDIRDNL LGISWVDSSW IPILNSGSVL DYFSERSNPF YDRTCNNEVV KMQRLTLEHL NQMVGIEYIL LHAQEPILFI IRKQQRQSP AQVIPLADYY IIAGVIYQAP DLGSVINSRV LTAVHGIQSA FDEAMSYCRY HPSKGYWWHF KDHEEQEKVK P KAKRKEEP SSIFQRQRVD ALLIDLRQKF PPRFVQQKSG EKPVPVDQAK KEAEPLPETV KSEEKESTKN IQQTVSTKGP PE KRMRLQ

UniProtKB: Mediator of RNA polymerase II transcription subunit 6

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分子 #4: Mediator of RNA polymerase II transcription subunit 7

分子名称: Mediator of RNA polymerase II transcription subunit 7
タイプ: protein_or_peptide / ID: 4 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 27.244252 KDa
配列文字列: MGEPQQVSAL PPPPMQYIKE YTDENIQEGL APKPPPPIKD SYMMFGNQFQ CDDLIIRPLE SQGIERLHPM QFDHKKELRK LNMSILINF LDLLDILIRS PGSIKREEKL EDLKLLFVHV HHLINEYRPH QARETLRVMM EVQKRQRLET AERFQKHLER V IEMIQNCL ...文字列:
MGEPQQVSAL PPPPMQYIKE YTDENIQEGL APKPPPPIKD SYMMFGNQFQ CDDLIIRPLE SQGIERLHPM QFDHKKELRK LNMSILINF LDLLDILIRS PGSIKREEKL EDLKLLFVHV HHLINEYRPH QARETLRVMM EVQKRQRLET AERFQKHLER V IEMIQNCL ASLPDDLPHS EAGMRVKAEP MDTDDNSNCP GQNEQQRESS GHRRDQIIEK DAALCVLIDE MNERP

UniProtKB: Mediator of RNA polymerase II transcription subunit 7

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分子 #5: Mediator of RNA polymerase II transcription subunit 8

分子名称: Mediator of RNA polymerase II transcription subunit 8
タイプ: protein_or_peptide / ID: 5 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 29.232008 KDa
配列文字列: MQREEKQLEA SLDALLNQVA DLKNSLGSFI YKLENEYDRL TWPSVLDSFA LLSGQLNTLN KVLKHEKTPL FRNQVIIPLV LSPDRDEDL MRQTEGRVPV FSHEVVPDHL RTKPDPEVEE QEKQLTTDAA RIGADAAQKQ IQSLNKMCSN LLEKISKEER E SESGGLRP ...文字列:
MQREEKQLEA SLDALLNQVA DLKNSLGSFI YKLENEYDRL TWPSVLDSFA LLSGQLNTLN KVLKHEKTPL FRNQVIIPLV LSPDRDEDL MRQTEGRVPV FSHEVVPDHL RTKPDPEVEE QEKQLTTDAA RIGADAAQKQ IQSLNKMCSN LLEKISKEER E SESGGLRP NKQTFNPGDT NALVAAVAFG KGLSNWRPSG SSGPGQPGQP GAGTILAGAS GLPQVQMPGA PNQQQPMLSG VQ MAQAGQP GKMPSGIKTN IKSASMHPYQ R

UniProtKB: Mediator of RNA polymerase II transcription subunit 8

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分子 #6: Mediator of RNA polymerase II transcription subunit 9

分子名称: Mediator of RNA polymerase II transcription subunit 9
タイプ: protein_or_peptide / ID: 6 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 15.729063 KDa
配列文字列:
MASSGVAGGR QAEDTLQPPP ELLPESKPPP PPQPLPVAAL PPPAAPRPQS PAGAKEENYS FLPLVHNVIK CMDKDSPDLH QDLNALKTK FQELRKLIGT MPGIHVSPEQ QQQQLHSLRE QVRTKNELLQ KYKSLCMFEI PKD

UniProtKB: Mediator of RNA polymerase II transcription subunit 9

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分子 #7: Mediator of RNA polymerase II transcription subunit 10

分子名称: Mediator of RNA polymerase II transcription subunit 10
タイプ: protein_or_peptide / ID: 7 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 15.683943 KDa
配列文字列:
MAEKFDHLEE HLEKFVENIR QLGIIVSDFQ PSSQAGLSQK LNFIVTGLQD IDKCRQQLHD ITVPLEVFEY IDQGRNPQLY TKECLERAL AKNEQVKGKI DTMKKFKSLL IQELSKVFPE DMAKYRSIRG EDHPPS

UniProtKB: Mediator of RNA polymerase II transcription subunit 10

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分子 #8: Mediator of RNA polymerase II transcription subunit 11

分子名称: Mediator of RNA polymerase II transcription subunit 11
タイプ: protein_or_peptide / ID: 8 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 13.147803 KDa
配列文字列:
MATYSLANER LRALEDIERE IGAILQNAGT AILELSKEKT NERLLDRQAA AFTTSVQHVE AELSAQIRYL TQVATGQPHE GSSYSSRKD CQMALKRVDY ARLKISDVAR TCEQMLEN

UniProtKB: Mediator of RNA polymerase II transcription subunit 11

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分子 #9: Mediator of RNA polymerase II transcription subunit 14

分子名称: Mediator of RNA polymerase II transcription subunit 14
タイプ: protein_or_peptide / ID: 9 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 161.144766 KDa
配列文字列: MAPVQLDNHQ LIPPGGGGGS SGGGGSSSGS ASAPAPPPPA AAVAAAAAAA ASPGYRLSTL IEFLLHRAYS ELMVLTDLLP RKSDVERKI EIVQFASRTR QLFVRLLALV KWANDAGKVE KCAMISSFLD QQAILFVDTA DRLASLARDA LVHARLPSFA I PYAIDVLT ...文字列:
MAPVQLDNHQ LIPPGGGGGS SGGGGSSSGS ASAPAPPPPA AAVAAAAAAA ASPGYRLSTL IEFLLHRAYS ELMVLTDLLP RKSDVERKI EIVQFASRTR QLFVRLLALV KWANDAGKVE KCAMISSFLD QQAILFVDTA DRLASLARDA LVHARLPSFA I PYAIDVLT TGSYPRLPTC IRDKIIPPDP ITKIEKQATL HQLNQILRHR LVTTDLPPQL ANLTVANGRV KFRVEGEFEA TL TVMGDDP EVPWRLLKLE ILVEDKETGD GRALVHSMQI DFIHQLVQSR LFADEKPLQD MYNCLHCFCL SLQLEVLHSQ TLM LIRERW GDLVQVERYH AGKSLSLSVW NQQVLGRKTG TASVHKVTIK IDENDVSKPL QIFHDPPLPA SDSKLVERAM KIDH LSIEK LLIDSVHARA HQRLQELKAI LRSFNANESS SIETALPALI VPILEPCGNS ECLHIFVDLH SGMFQLMLYG LDPAT LEDM EKSLNDDMKR IIPWIQQLKF WLGQQRCKQS IKHLPTITTE TLQLANYSTH PIGSLSKNKL FIKLTRLPQY YIVVEM LEV PNKPTQLSYN YYFMSVSTAD REDSPVMALL LQQFKDNIQD LMSYTKTGKQ TRTGTKHKLS DDPCPIDSKK AKRSGEM CA FNKVLAHFVA MCDTNMPFVG LRLELSNLEI PHQGVQVEGD GFNHAIRLLK IPPCKGISEE TQKALDRSLL DCTFRLQG R NNRTWVAELV FANCPLNGTS TREQGPSRHV YLTYENLLSE PVGGRKVVEM FLNDWSSIAR LYECVLEFAR SLPEIPAHL NIFSEVRVYN YRKLILCYGT TKGSSISIQW NSIHQKFHIA LGTVGPNSGC SNCHNTILHQ LQEMFNKTPN VVQLLQVLFD TQAPLNAIN KLPTVPMLGL TQRTNTAYQC FSILPQSSTH IRLAFRNMYC IDIYCRSRGV VAIRDGAYSL FDNSKLVEGF Y PAPGLKTF LNMFVDSNQD ARRRSVNEDD NPPSPIGGDM MDSLISQLQP PQQQPFPKQP GTSGAYPLTS PPTSYHSTVN QS PSMMHTQ SPGNLHAASS PSGALRAPSP ASFVPTPPPS SHGISIGPGA SFASPHGTLD PSSPYTMVSP SGRAGNWPGS PQV SGPSPA TRLPGMSPAN PSLHSPVPDV SHSPRAGTSS QTMPTNMPPP RKLPQRSWAA SIPTILTHSA LNILLLPSPT PGLV PGLAG SYLCSPLERF LGSVIMRRHL QRIIQQETLQ LINSNEPGVI MFKTDALKCR VALSPKTNQT LQLKVTPENA GQWKP DELQ VLEKFFETRV AGPPFKANTL IAFTKLLGAP THILRDCVHI MKLELFPDQA TQLKWNVQFC LTIPPSAPPI APPGTP AVV LKSKMLFFLQ LTQKTSVPPQ EPVSIIVPII YDMASGTTQQ ADIPRQQNSS VAAPMMVSNI LKRFAEMNPP RQGECTI FA AVRDLMANLT LPPGGRP

UniProtKB: Mediator of RNA polymerase II transcription subunit 14

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分子 #10: Mediator of RNA polymerase II transcription subunit 15

分子名称: Mediator of RNA polymerase II transcription subunit 15
タイプ: protein_or_peptide / ID: 10 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 86.68293 KDa
配列文字列: MDVSGQETDW RSAAFRQKLV SQIEDAMRKA GVAHSKSSKD MESHVFLKAK TRDEYLSLVA RLIIHFRDIH NKKSQASVSD PMNALQSLT GGPTPGAAGI GMPPRGPGQS LGGMGGLGAM GQPLPLSGQP PPGTSGMAPH GMAVVSTATP QTQLQLQQVA L QQQQQQQQ ...文字列:
MDVSGQETDW RSAAFRQKLV SQIEDAMRKA GVAHSKSSKD MESHVFLKAK TRDEYLSLVA RLIIHFRDIH NKKSQASVSD PMNALQSLT GGPTPGAAGI GMPPRGPGQS LGGMGGLGAM GQPLPLSGQP PPGTSGMAPH GMAVVSTATP QTQLQLQQVA L QQQQQQQQ QQQFQQQQAA LQQQQQQQQQ QQQQQQFQAQ QNAMQQQFQA VVQQQQLQQQ QQQQHLIKLH HQSQQQQIQQ QQ LQRMAQL QLQQQQQQQQ QQALQAQPPM QQPSMQQPQP PPSQALPQQL SQLHHPQHHQ PPPQAQQSPI AQNQPPQIPP QSQ SQPLVS QAQALPGPML YAAQQQLKFV RAPMVVQQPQ VQPQVQQVQP QVQPQAAVQA AQSAQMVAPG VQMIAEALAQ GGMH VRARF PPTSTMSAGP SSSISLGGQP TTQVSQSSLT MLSSPSPGQQ VQTPQSMPPP PQPSPQPGSQ PNSNVSSGPA PSPSS FLPS PSPQPSQSPV TARTPQNFSV PSPGPLNTPV NPSSVMSPAG SSQAEEQQYL DKLKQLSKYI EPLRRMINKI DKNEDR KKD LSKMKSLLDI LTDPSKRCPL KTLQKCEIAL EKLKNDMAVP TPPPPPVLPT KQQDLCQPLL DAVLANIRSP VFNHSLY RT FVPAMMAIHG PPIVSPVVCS RKRRFEEDER QSIPNVLQGE VARLDPKFLV NLDPSHCSNN GTVHLICKLD DKDLPSVP P LELSVPADYP AQSPMWIDRQ WQYDANPFLQ SVHRCMTSRL LQLPDKHSVT ALLNTWAQSI HQACLSAA

UniProtKB: Mediator of RNA polymerase II transcription subunit 15

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分子 #11: Mediator of RNA polymerase II transcription subunit 16

分子名称: Mediator of RNA polymerase II transcription subunit 16
タイプ: protein_or_peptide / ID: 11 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 91.890484 KDa
配列文字列: MDLAYVCEWE KWAKSTYCPS LPLACAWSCR NLIAFTTDLR NDDQDLTHMI HILDTEHPWE VHSVSSGHSE AITCLEWDQS GSRLLSADA DGQIKCWSMA DHLANSWESS VGSQVEGDPI VALSWLHNGV KLALHVEKSG ASSFGEKFSR VKFSPSLTLF G GKPMEGWI ...文字列:
MDLAYVCEWE KWAKSTYCPS LPLACAWSCR NLIAFTTDLR NDDQDLTHMI HILDTEHPWE VHSVSSGHSE AITCLEWDQS GSRLLSADA DGQIKCWSMA DHLANSWESS VGSQVEGDPI VALSWLHNGV KLALHVEKSG ASSFGEKFSR VKFSPSLTLF G GKPMEGWI AVTVSGLVTV SLLKPSGQVL TSTESLCRLR GRVALADIAF TGGGNIVVAA ADGSSASPVK FYKVCVSVVS EK CRIDTEI LPSLFMRCTT DPNRKDRFPA ITHLKFLARD MSEQVLLCAS SQTSSLVECW SLRKEGLPVN NIFQQISPVV GDK QPMILK WRILSATNDL DRVSAVALPK LPISLTNTDL KVASDTQFYP GLGLALAFQD GSVHMVHRLS LQTMAVFYSS APRS LDEPA LKRPRTTCPA VHFKAMQLSW TSLALVGIDN HGKLSMLRIS PSLGHPLEPK LALQHLLFLL EYCMVTGYDW WDILL HVQP GMVQSLVERL HEEYTRQKPA LQQVLSTRIL AMKASLCKLS PCTVARVCDY HTKLFLMAIT STLKSLLRPH FLNTPD KSP GDRLAEICAK ITDVDIDKVM INLKTEEFVL DMNTLQALQQ LLQWVGDFVL YLLVSLPNQG SPLRPGHSFL RDGTSLG ML RELMVVIRIW GLLKPSCLPV YTATSDTQDS MSLLFRLLTK LWICCRDEGA ASEPDEGLVD ECCLLPSQLL VPNLDWLP A SDGLVSRLQP KQPLRLRFGR APTLPSSTST LQLDGLTRAP GQPKIDHLRR LHLGAYPTEE CKACTRCGCV TMLKSPNKT TAVTQWEQRW IKNCLCGGLW RRVPLSCS

UniProtKB: Mediator of RNA polymerase II transcription subunit 16

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分子 #12: Mediator of RNA polymerase II transcription subunit 17

分子名称: Mediator of RNA polymerase II transcription subunit 17
タイプ: protein_or_peptide / ID: 12 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 72.555609 KDa
配列文字列: MSGVRAVRIS IESACEKQVQ EVGLDGTETY LQPLSMSQNL ARLAQRIDFS QGSGSEEEEA AGPDGDAPDW GGAGADQDDE EGLVKFQPS LWPWDSVRNN LRSALTEMCV LYDVLSIVRD KKFMTLDPVS QDALPPKQSP QTLQLISKKK SLAGAAQILL K GAERLTKS ...文字列:
MSGVRAVRIS IESACEKQVQ EVGLDGTETY LQPLSMSQNL ARLAQRIDFS QGSGSEEEEA AGPDGDAPDW GGAGADQDDE EGLVKFQPS LWPWDSVRNN LRSALTEMCV LYDVLSIVRD KKFMTLDPVS QDALPPKQSP QTLQLISKKK SLAGAAQILL K GAERLTKS VAENQENKLQ RDFNSELLRL RQHWKLRKVG DKILGDLSYR SAGSLFPHHG TFEVIKNTDI DLDKKIPEDY CP LDVQIPS DLEGSAYIKV SIQKQAPDIG DLGTVNLFKR PLPKSKPGSP HWQTKLEAAQ NVLLCKEIFA QLSREAVQIK SQI PHIVVK NQIISQPFPS LQLSISLCHS SDDKKSQKCA AEKPGQEDHL YVLEHNLHLL IREFHKQTLS SIVMPHPASA PFGH KRMRL SGPQAFDKNE INSIQSTEGL LEKIIKQAKH IFLRSRTAAT IDSLASRIED PQIQAHWSNI NDVYESSVKV LITSQ GYEQ ICKSIQLQLN IGVEQVRVVH RDGRVIMLSH QEQELQDFLL SQMSQHQVHA VQQLAKVMGW QVLSFSNHVG LGPIES IGN ASAITVASPS GDYAISVRNG PESGSKIMVQ FPRNQCKDLP KSDVLQDSKW SHLRGPFKEV QWNKMEGRNF VYKMELL MS ALSPCLL

UniProtKB: Mediator of RNA polymerase II transcription subunit 17

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分子 #13: Mediator of RNA polymerase II transcription subunit 18

分子名称: Mediator of RNA polymerase II transcription subunit 18
タイプ: protein_or_peptide / ID: 13 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 23.675652 KDa
配列文字列: MEAPPVTMMP VTGGTINMME YLLQGSVLDH SLESLIHRLR GLCDNMEPET FLDHEMVFLL KGQQASPFVL RARRSMDRAG APWHLRYLG QPEMGDKNRH ALVRNCVDIA TSENLTDFLM EMGFRMDHEF VAKGHLFRKG IMKVVVYKIF RILVPGNTDS T EALSLSYL ...文字列:
MEAPPVTMMP VTGGTINMME YLLQGSVLDH SLESLIHRLR GLCDNMEPET FLDHEMVFLL KGQQASPFVL RARRSMDRAG APWHLRYLG QPEMGDKNRH ALVRNCVDIA TSENLTDFLM EMGFRMDHEF VAKGHLFRKG IMKVVVYKIF RILVPGNTDS T EALSLSYL VELSVVAPAG QDMVSDDMRN FAEQLKPLVH LEKIDPKRLM

UniProtKB: Mediator of RNA polymerase II transcription subunit 18

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分子 #14: Mediator of RNA polymerase II transcription subunit 19

分子名称: Mediator of RNA polymerase II transcription subunit 19
タイプ: protein_or_peptide / ID: 14 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 25.866531 KDa
配列文字列: MENFTALFGA QTDPPPPPSA LGFGPGKPPP PPPPPPGGGP GAAPPSTATS APAGADKSTA GSGPFYLMRE LPGSTELTGS TNLITHYNL EQAYNKFCGK KVKEKLSNFL PDLPGMIDLP GSHDNSSLRS LIEKPPILGG SFNPITGTML SGFRLHTGPL P EQCRLMHI ...文字列:
MENFTALFGA QTDPPPPPSA LGFGPGKPPP PPPPPPGGGP GAAPPSTATS APAGADKSTA GSGPFYLMRE LPGSTELTGS TNLITHYNL EQAYNKFCGK KVKEKLSNFL PDLPGMIDLP GSHDNSSLRS LIEKPPILGG SFNPITGTML SGFRLHTGPL P EQCRLMHI QPPKKKNKHK HKQSRTQDPV PPETPSDSDH KKKKKKKEED PERKRKKKEK KKKKNRHSPD HPGMGSSQAS SS

UniProtKB: Mediator of RNA polymerase II transcription subunit 19

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分子 #15: Mediator of RNA polymerase II transcription subunit 20

分子名称: Mediator of RNA polymerase II transcription subunit 20
タイプ: protein_or_peptide / ID: 15 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 23.213775 KDa
配列文字列: MGVTCVSQMP VAEGKSLQQT VELLTKKLEM LGAEKQGTFC VDCETYHTAA STLGSQGQAG KLMYVMHNSE YPLSCFALFE NGPCLIADT NFDVLMVKLK GFFQSAKASK IETRGTRYQY CDFLVKVGTV TMGPSARGIS VEVEYGPCVV ASDCWSLLLE F LQSFLGSH ...文字列:
MGVTCVSQMP VAEGKSLQQT VELLTKKLEM LGAEKQGTFC VDCETYHTAA STLGSQGQAG KLMYVMHNSE YPLSCFALFE NGPCLIADT NFDVLMVKLK GFFQSAKASK IETRGTRYQY CDFLVKVGTV TMGPSARGIS VEVEYGPCVV ASDCWSLLLE F LQSFLGSH APGAPTVFGN RHDAVYGPAD TMIQYMELFN KIRKQQQVPV AGIR

UniProtKB: Mediator of RNA polymerase II transcription subunit 20

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分子 #16: Mediator of RNA polymerase II transcription subunit 21

分子名称: Mediator of RNA polymerase II transcription subunit 21
タイプ: protein_or_peptide / ID: 16 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 15.600307 KDa
配列文字列:
MADRLTQLQD AVNSLADQFC NAIGVLQQCG PPASFSNIQT AINKDQPANP TEEYAQLFAA LIARTAKDID VLIDSLPSEE STAALQAAS LYKLEEENHE AATCLEDVVY RGDMLLEKIQ SALADIAQSQ LKTRSVTHSH SLPDS

UniProtKB: Mediator of RNA polymerase II transcription subunit 21

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分子 #17: Mediator of RNA polymerase II transcription subunit 22

分子名称: Mediator of RNA polymerase II transcription subunit 22
タイプ: protein_or_peptide / ID: 17 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 22.30475 KDa
配列文字列: MAQQRALPQS KETLLQSYNK RLKDDIKSIM DNFTEIIKTA KIEDETQVSR ATQGEQDNYE MHVRAANIVR AGESLMKLVS DLKQFLILN DFPSVNEAID QRNQQLRALQ EECDRKLITL RDEVSIDLYE LEEEYYSSSS SLCEANDLPL CEAYWRLDLD A DSADGLSA ...文字列:
MAQQRALPQS KETLLQSYNK RLKDDIKSIM DNFTEIIKTA KIEDETQVSR ATQGEQDNYE MHVRAANIVR AGESLMKLVS DLKQFLILN DFPSVNEAID QRNQQLRALQ EECDRKLITL RDEVSIDLYE LEEEYYSSSS SLCEANDLPL CEAYWRLDLD A DSADGLSA PLLASPETGA GPLQSAAPVH SHGGGPGPTE HT

UniProtKB: Mediator of RNA polymerase II transcription subunit 22

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分子 #18: Mediator of RNA polymerase II transcription subunit 23

分子名称: Mediator of RNA polymerase II transcription subunit 23
タイプ: protein_or_peptide / ID: 18 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 156.265656 KDa
配列文字列: METQLQSIFE EVVKTEIIEE AFPGMFMDTP EDEKTKLISC LAAFRQFWSG LSQESHEQCV QWIVKFIHGQ HSPKRISFLY DCLAMAVET GLLPPRMVCE SLINSDSLEW ERTQLWALTF KLVRKIIGGV DYKGVRDLLK AILEKILTIP NTVSSAVVQQ L LAAREVIA ...文字列:
METQLQSIFE EVVKTEIIEE AFPGMFMDTP EDEKTKLISC LAAFRQFWSG LSQESHEQCV QWIVKFIHGQ HSPKRISFLY DCLAMAVET GLLPPRMVCE SLINSDSLEW ERTQLWALTF KLVRKIIGGV DYKGVRDLLK AILEKILTIP NTVSSAVVQQ L LAAREVIA YILERNACLL PAYFAVTEIR KLYPEGKLPH WLLGNLVSDF VDTFRPTARI NSICGRCSLL PVVNNSGAIC NS WKLDPAT LRFPLKGLLP YDKDLFEPQT ALLRYVLEQP YSRDMVCNML GLNKQHKQRC PVLEDQLVDL VVYAMERSET EEK FDDGGT SQLLWQHLSS QLIFFVLFQF ASFPHMVLSL HQKLAGRGLI KGRDHLMWVL LQFISGSIQK NALADFLPVM KLFD LLYPE KECIPVPDIN KPQSTHAFAM TCIWIHLNRK AQNGDSTLQI PIPHSLKLHH EFLQQSLRNK SLQMNDYKIA LLCNA YSTN SECFTLPMGA LVETIYGNGI MRVPLPGTSC LASASVTPLP MNLLDSLTVH AKMSLIHSIA TRVIKLAHTK SSVALA PAL VETYSRLLVY MEIESLGIKG FISQLLPTVF KSHAWGILHT LLEMFSHRMH HIQPHYRVQL LSHLHTLAAV AQTNQNQ LH LCVESTALRL ITALGSSEVQ PQFTRFLNDP KTVLSAESEE LNRALILTLA RATHVTDFFT GSDSIQGTWC KDILQTIM N FTPHNWASHT LSCFPAPLQA FFKQNNVPQE SRFNLKKNVE EEYRKWKSMT DENEIITQFS VQGFPPLFLC LLWKMLLET DHISQIGYKV LERIGARALV AHVRTFADFL VYEFSTSAGG QQLNKCIEIL NDMVWKYNIV TLDRLILCLA MRSHEGNEAQ VCYFIIQLL LLKPNDFRNR VSDFVKENSP EHWLQSDWHT KHMSYHKKYP EKLYFEGLAE QVDPPVPIQS PYLPIYFGNV C LRFLPVFD IVIHRFLELL PVSKSLETLL DHLGGLYKFH DRPVTYLYNT LHYYEMCLRN RDHLKRKLVH AIIGSLKDNR PQ GWCLSDT YLKHAMNARE DNPWVPEDSY YCKLIGRLVD TMAGKSPGPF PNCDWRFNEF PNPAAHALHV TCVELMALAV PGK DVGNAL LNVVLKSQPL VPRENITAWM NAIGLIITAL PEPYWIVLHD RIVNVISSSS LTSETEWVGY PFRLFDFTAC HQSY SEMSC SYTLALAHAV WHHSSIGQLS LIPKFLTEAL LPVVKTEFQL LYVYHLVGPF LQRFQQERTR CMIEIGVAFY DMLLN VDQC STHLNYMDPI CDFLYHMKYM FTGDSVKEQV EKIICNLKPA LKLRLRFITH ISKMEPAVPP QALNSGSPAP QSNQVP ASL PVTQ

UniProtKB: Mediator of RNA polymerase II transcription subunit 23

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分子 #19: Mediator of RNA polymerase II transcription subunit 24

分子名称: Mediator of RNA polymerase II transcription subunit 24
タイプ: protein_or_peptide / ID: 19 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 110.106867 KDa
配列文字列: MKVVNLKQAI LQAWKERWSD YQWAINMKKF FPKGATWDIL NLAEALLEQA MIGPSPNPLI LSYLKYAISS QMVSCSSVLT AISKFDDFS RDLCVQALLD IMDMFCDRLS CHGKAEECIG LCRALLSALH WLLRCTAASA ERLQEGLEAG TPAPGEKQLA L CLQCLEKT ...文字列:
MKVVNLKQAI LQAWKERWSD YQWAINMKKF FPKGATWDIL NLAEALLEQA MIGPSPNPLI LSYLKYAISS QMVSCSSVLT AISKFDDFS RDLCVQALLD IMDMFCDRLS CHGKAEECIG LCRALLSALH WLLRCTAASA ERLQEGLEAG TPAPGEKQLA L CLQCLEKT LSSTKNRALL HIAKLEEASS WTAIEHSLLK LGEILANLSN PQLRSQAERC GTLIRSIPSM LSVHSEQLHK TG FPTIHAL ILLEGTMNLT GEMQPLVEQL MMVKRMQHIP TPLFVLEIWK ACFVGLIESP EGTQELKWTA FTYLKIPQVL VKL KKYFHG EKDFTEDVNC AFEFLLKLTP LLDKADQRCN CDCTNFLLQE CNKQGLLSEV NFASLVGKRT ADRDPQLKSS ENAN IQPNP GLILRAEPTV TNILKTMDAD HSKSPEGLLG VLGHMLSGKS LDLLLAAAAA TGKLKSFARK FINLNEFTTH GSGES TKTA SVRALLFDIS FLMLCHVAQT YGSEVILSES SSGEEVPFFE TWMQTCMPEE GKILNPDHPC FRPDSTKVES LVALLN NSS EMKLVQMKWH EACLSISAAI LEILNAWENG VLAFESIQKI TDNIKGKVCS LAVCAVAWLV AHVRMLGLDE REKSLQM IR QLAGPLYSEN TLQFYNERVV IMNSILEHMC ADVLQQTATQ IKFPSTGVDT MPYWNLLPPK RPIKEVLTDI FAKVLEKG W VDSRSIHILD TLLHMGGVYW FCNNLIKELL KETRKEHTLR AVQLLYSIFC LDMQQVTLVL LGHILPGLLT DSSKWHSLM DPPGTALAKL AVWCALSSYS SHKGQASSRQ KKRHREDIED YVSLFPVEDM QPSKLMRLLS SSDDDANILS SPTDRSMNSS LSASQLHTV NMRDPLNRVL ANLFLLISSI LGSRTAGPHT QFVQWFMEEC VGCLEQDSRG SILQFMPFTT VSELVKVSAM S SPKVVLAI TDLSLPLGRQ VAAKAIAAL

UniProtKB: Mediator of RNA polymerase II transcription subunit 24

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分子 #20: Mediator of RNA polymerase II transcription subunit 25

分子名称: Mediator of RNA polymerase II transcription subunit 25
タイプ: protein_or_peptide / ID: 20 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 78.173328 KDa
配列文字列: MVPGSEGPAR AGGLVADVVF VIEGTANLGP YFEELRKHYL LPAIEYFNGG PPAETDFGGD YGGTQYSLVV FNTVDCAPES YVQCHAPTS SAYEFVTWLD GIKFMGGGGE SCSLIAEGLS TALQLFDDFK KMREQIGQTH RVCLLICNSP PYLLPAVEST T YSGCTTES ...文字列:
MVPGSEGPAR AGGLVADVVF VIEGTANLGP YFEELRKHYL LPAIEYFNGG PPAETDFGGD YGGTQYSLVV FNTVDCAPES YVQCHAPTS SAYEFVTWLD GIKFMGGGGE SCSLIAEGLS TALQLFDDFK KMREQIGQTH RVCLLICNSP PYLLPAVEST T YSGCTTES LVQKIGERGI HFSIVSPRKL PALRLLFEKA APPALLEPLQ QPADVSQDPR HMVLVRGLVL PVGGSSTSGS LQ TKQAVPL PPAPASAATL SAAPPQALPP VPPQYQVPGN LSAAQVAAQN AVEAAKSQKA GLGPRFSPIN PLQQAAPGVG PPF SQAPAP PLAPVPPGAP KPPPASQPSL VSTVAPGPVL AAPAQPGAPS LAGTVTPGGV NGPSAAQLGG PALGGQQSVS NKLL AWSGV LEWQEKPKPA SVDANTKLTR SLPCQVYVNH GENLKTEQWP QKLIMQLIPQ QLLTTLGPLF RNSRMVQFHF TNKDL ESLK GLYRIMGNGF AGCVHFPHTA PCEVRVLMLL YSSKKKIFMG LIPYDQSGFV NGIRQVITNH KQVQQQKLEQ QRGMGA QQA PPVLGPILEE QARPPQNLLQ LRAPQPQPQG AVGASAATGQ PQPQGATQAP TGAPQGPPGA APGPPPSGPI LRPQNPG AN PQLRSLLLNP APPQTGVPPP QASLHHLQPP GAPTLLPPHQ SMGQPQLGPQ LLHPPPAQSW PTQLPQRAPL PGQMLLSG G PRGPVPQPGL QPSVMEDDIL MDLI

UniProtKB: Mediator of RNA polymerase II transcription subunit 25

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分子 #21: Mediator of RNA polymerase II transcription subunit 26

分子名称: Mediator of RNA polymerase II transcription subunit 26
タイプ: protein_or_peptide / ID: 21 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 64.773477 KDa
配列文字列: MTAAPASPQQ MRDRLLQAID SQSNIRNMVA VLEVISSLER YPITKEALEE TRLGKLINDV RKKTKNEELA KRAKRLLRSW QKLIEPVHQ NEVALRALAG AAGSANGGAH NCRPEMGVAG APKSIHDLKN RNDIQRLPGQ RLDRLGSRKR RGDQRDLGHP G PPHKVSKG ...文字列:
MTAAPASPQQ MRDRLLQAID SQSNIRNMVA VLEVISSLER YPITKEALEE TRLGKLINDV RKKTKNEELA KRAKRLLRSW QKLIEPVHQ NEVALRALAG AAGSANGGAH NCRPEMGVAG APKSIHDLKN RNDIQRLPGQ RLDRLGSRKR RGDQRDLGHP G PPHKVSKG SPDPLVPNAS PLPTNGISGS PESLPSPLDG SGHLGPDGSR LEPSDNEKHS TKIPVNAVRP RPSSPGLGKP PV PCLQTKA AQLQQLDRAD ESPGPPYPRG SSRCSFSPRN SRHEGSFSRH RSSYIPKGQV SSPSPWPQPP DNTQVPSPLP LAQ PPTPPV RRQELLPNAE SPVHWPEQSE GHPRLTGPAC RAGFSPDSSK ADSDATSSGG SDSKKKKRYR PRDYTVNLDG QVAE AGVKP VRLKERKLTF DPMTRQIRPL TQKEPVRADS PVPTEQLPRT ELEQQEVKAS LQSPFEQTNW KELSRNEIIQ SYLSR QSSL LSSSGAQTPG AHHFMAEYLK QEESSRQGAR QPHVLLPLPT PTDLPGLTRE VTQDDLDRIQ AQQWPGVNGC EDTQGN WYD WTQCISLDPH GDDGRLNILP YVCLD

UniProtKB: Mediator of RNA polymerase II transcription subunit 26

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分子 #22: Mediator of RNA polymerase II transcription subunit 27

分子名称: Mediator of RNA polymerase II transcription subunit 27
タイプ: protein_or_peptide / ID: 22 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 35.343605 KDa
配列文字列: MADVLSVGVN LEAFSQAISA IQALRSSVSR VFDCLKDGMR NKETLEGREK AFIANFQDNL HSVNRDLNEL ERLSNLVGKP SENHPLHNS GLLSLDPVQD KTPLYSQLLQ AYKWSNKLQY HAGLASGLLN QQSLKRSANQ MGVSAKRRPK AQPTTLVLPP Q YVDDVISR ...文字列:
MADVLSVGVN LEAFSQAISA IQALRSSVSR VFDCLKDGMR NKETLEGREK AFIANFQDNL HSVNRDLNEL ERLSNLVGKP SENHPLHNS GLLSLDPVQD KTPLYSQLLQ AYKWSNKLQY HAGLASGLLN QQSLKRSANQ MGVSAKRRPK AQPTTLVLPP Q YVDDVISR IDRMFPEMSI HLSRPNGTSA MLLVTLGKVL KVIVVMRSLF IDRTIVKGYN ESVYTEDGKL DIWSKSSYQV FQ KVTDHAT TALLHYQLPQ MPDVVVRSFM TWLRSYIKLF QAPCQRCGKF LQDGLPPTWR DFRTLEAFHD TCRQ

UniProtKB: Mediator of RNA polymerase II transcription subunit 27

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分子 #23: Mediator of RNA polymerase II transcription subunit 28

分子名称: Mediator of RNA polymerase II transcription subunit 28
タイプ: protein_or_peptide / ID: 23 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 19.558145 KDa
配列文字列:
MAASLGGMFT GQPPGPPPPP PGLPGQASLL QAAPGAPRPS NSTLVDELES SFEACFASLV SQDYVNGTDQ EEIRTGVDQC IQKFLDIAR QTECFFLQKR LQLSVQKPDQ VIKEDVSELR SELQRKDALV QKHLTKLRHW QQVLEDINVQ HKKPADMPQG S LAFLEQAS ANIPAPLKQT

UniProtKB: Mediator of RNA polymerase II transcription subunit 28

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分子 #24: Mediator of RNA polymerase II transcription subunit 29

分子名称: Mediator of RNA polymerase II transcription subunit 29
タイプ: protein_or_peptide / ID: 24 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 21.027727 KDa
配列文字列: MAAPQPQAAA VSSASGVSGP GSAGGPGPQQ QPQPTQLVGS AQSGLLQQQQ QDFDPVQRYK MLIPQLKESL QTLMKVAAQN LIQNTNIDN GQKSSDAPLQ RFDKCLEEFY ALCDQLELCL RLAHECLSQS CDSAKHSPTL VPTATKPDAV QPDSLPYPQY L AVIKAQIT ...文字列:
MAAPQPQAAA VSSASGVSGP GSAGGPGPQQ QPQPTQLVGS AQSGLLQQQQ QDFDPVQRYK MLIPQLKESL QTLMKVAAQN LIQNTNIDN GQKSSDAPLQ RFDKCLEEFY ALCDQLELCL RLAHECLSQS CDSAKHSPTL VPTATKPDAV QPDSLPYPQY L AVIKAQIT CAKDIHTALL DCANKVTGKT TAPSTGPGGS L

UniProtKB: Mediator of RNA polymerase II transcription subunit 29

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分子 #25: Mediator of RNA polymerase II transcription subunit 30

分子名称: Mediator of RNA polymerase II transcription subunit 30
タイプ: protein_or_peptide / ID: 25 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 20.383354 KDa
配列文字列:
MSTPPLAPTG MASGPFGGPQ AQQAAREVNT ATLCRIGQET VQDIVYRTME IFQLLRNMQL PNGVTYHTGT YQDRLTKLQD HLRQLSILF RKLRLVYDKC NENCGGMDPI PVEQLIPYVD EDGSKNDDRA GPPRFASEER REIVEVNKKL KQKNQQLKQI M DQLRNLIW DINAMLAMRN

UniProtKB: Mediator of RNA polymerase II transcription subunit 30

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分子 #26: Mediator of RNA polymerase II transcription subunit 31

分子名称: Mediator of RNA polymerase II transcription subunit 31
タイプ: protein_or_peptide / ID: 26 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 15.792077 KDa
配列文字列:
MAAAVAMETD DAGNRLRFQL ELEFVQCLAN PNYLNFLAQR GYFKDKAFVN YLKYLLYWKE PEYAKYLKYP QCLHMLELLQ YEHFRKELV NAQCAKFIDE QQILHWQHYS RKRVRLQQAL AEQQQQNNTA GK

UniProtKB: Mediator of RNA polymerase II transcription subunit 31

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分子 #27: Unknown Peptide

分子名称: Unknown Peptide / タイプ: protein_or_peptide / ID: 27 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Mus musculus (ハツカネズミ)
分子量理論値: 1.720111 KDa
配列文字列:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)

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実験情報

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構造解析

手法クライオ電子顕微鏡法
解析単粒子再構成法
試料の集合状態particle

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試料調製

濃度0.1 mg/mL
緩衝液pH: 7.9
糖包埋材質: ice
凍結凍結剤: ETHANE / チャンバー内湿度: 100 % / チャンバー内温度: 277 K / 装置: HOMEMADE PLUNGER

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電子顕微鏡法

顕微鏡FEI TALOS ARCTICA
撮影フィルム・検出器のモデル: GATAN K3 (6k x 4k) / 平均電子線量: 22.5 e/Å2
電子線加速電圧: 200 kV / 電子線源: FIELD EMISSION GUN
電子光学系C2レンズ絞り径: 50.0 µm / 照射モード: FLOOD BEAM / 撮影モード: BRIGHT FIELD / Cs: 2.7 mm / 最大 デフォーカス（公称値）: 3.5 µm
最小 デフォーカス（公称値）: 0.7000000000000001 µm
実験機器
モデル: Talos Arctica / 画像提供: FEI Company

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画像解析

初期モデルモデルのタイプ: INSILICO MODEL
最終 再構成解像度のタイプ: BY AUTHOR / 解像度: 4.68 Å / 解像度の算出法: FSC 0.143 CUT-OFF / 使用した粒子像数: 199078
初期 角度割当タイプ: MAXIMUM LIKELIHOOD
最終 角度割当タイプ: MAXIMUM LIKELIHOOD
FSC曲線 (解像度の算出)

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万見について

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お知らせ

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2022年2月9日: EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

  • EMDBのヘッダファイルのバージョン3が、公式のフォーマットとなりました。
  • これまでは公式だったバージョン1.9は、アーカイブから削除されます。

関連情報:EMDBヘッダ

外部リンク:wwPDBはEMDBデータモデルのバージョン3へ移行します

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2020年8月12日: 新型コロナ情報

新型コロナ情報

URL: https://pdbjlvh1.pdbj.org/emnavi/covid19.php

新ページ: EM Navigatorに新型コロナウイルスの特設ページを開設しました。

関連情報:Covid-19情報 / 2020年3月5日: 新型コロナウイルスの構造データ

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2020年3月5日: 新型コロナウイルスの構造データ

新型コロナウイルスの構造データ

関連情報:万見生物種 / 2020年8月12日: 新型コロナ情報

外部リンク:COVID-19特集ページ - PDBj / 今月の分子2020年2月：コロナウイルスプロテーアーゼ

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2019年1月31日: EMDBのIDの桁数の変更

EMDBのIDの桁数の変更

  • EMDBエントリに付与されているアクセスコード(EMDB-ID)は4桁の数字(例、EMD-1234)でしたが、間もなく枯渇します。これまでの4桁のID番号は4桁のまま変更されませんが、4桁の数字を使い切った後に発行されるIDは5桁以上の数字(例、EMD-12345)になります。5桁のIDは2019年の春頃から発行される見通しです。
  • EM Navigator/万見では、接頭語「EMD-」は省略されています。

関連情報:Q: 「EMD」とは何ですか？ / 万見/EM NavigatorにおけるID/アクセスコードの表記

外部リンク:EMDB Accession Codes are Changing Soon! / PDBjへお問い合わせ

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2017年7月12日: PDB大規模アップデート

PDB大規模アップデート

  • 新バージョンのPDBx/mmCIF辞書形式に基づくデータがリリースされました。
  • 今回の更新はバージョン番号が4から5になる大規模なもので、全エントリデータの書き換えが行われる「Remediation」というアップデートに該当します。
  • このバージョンアップで、電子顕微鏡の実験手法に関する多くの項目の書式が改定されました(例：em_softwareなど)。
  • EM NavigatorとYorodumiでも、この改定に基づいた表示内容になります。

外部リンク:wwPDB Remediation / OneDepデータ基準に準拠した、より強化された内容のモデル構造ファイルが、PDBアーカイブで公開されました。

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万見 (Yorodumi)

幾万の構造データを、幾万の視点から

  • 万見(Yorodumi)は、EMDB/PDB/SASBDBなどの構造データを閲覧するためのページです。
  • EM Navigatorの詳細ページの後継、Omokage検索のフロントエンドも兼ねています。

関連情報:EMDB / PDB / SASBDB / 3つのデータバンクの比較 / 万見検索 / 2016年8月31日: 新しいEM Navigatorと万見 / 万見文献 / Jmol/JSmol / 機能・相同性情報 / 新しいEM Navigatorと万見の変更点

他の情報も見る