登録情報 | データベース: PDB / ID: 3g70 |
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タイトル | Design and Preparation of Potent, Non-Peptidic, Bioavailable Renin Inhibitors |
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要素 | Renin |
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キーワード | HYDROLASE / human renin / Aspartyl protease / Cleavage on pair of basic residues / Disease mutation / Glycoprotein / Membrane / Protease / Secreted / Zymogen |
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機能・相同性 | 機能・相同性情報
renin / juxtaglomerular apparatus development / mesonephros development / response to cGMP / renin-angiotensin regulation of aldosterone production / drinking behavior / regulation of MAPK cascade / response to immobilization stress / angiotensin maturation / amyloid-beta metabolic process ...renin / juxtaglomerular apparatus development / mesonephros development / response to cGMP / renin-angiotensin regulation of aldosterone production / drinking behavior / regulation of MAPK cascade / response to immobilization stress / angiotensin maturation / amyloid-beta metabolic process / Metabolism of Angiotensinogen to Angiotensins / cell maturation / response to cAMP / hormone-mediated signaling pathway / kidney development / insulin-like growth factor receptor binding / regulation of blood pressure / male gonad development / cellular response to xenobiotic stimulus / apical part of cell / peptidase activity / response to lipopolysaccharide / aspartic-type endopeptidase activity / signaling receptor binding / proteolysis / extracellular space / extracellular region / plasma membrane類似検索 - 分子機能 Renin-like domain / Aspartic peptidase, N-terminal / A1 Propeptide / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ...Renin-like domain / Aspartic peptidase, N-terminal / A1 Propeptide / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2 Å |
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データ登録者 | Bezencon, O. / Bur, D. / Prade, L. / Weller, T. / Boss, C. / Fischli, W. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2009 タイトル: Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors 著者: Bezencon, O. / Bur, D. / Weller, T. / Richard-Bildstein, S. / Remen, L. / Sifferlen, T. / Corminboeuf, O. / Grisostomi, C. / Boss, C. / Prade, L. / Delahaye, S. / Treiber, A. / Strickner, P. ...著者: Bezencon, O. / Bur, D. / Weller, T. / Richard-Bildstein, S. / Remen, L. / Sifferlen, T. / Corminboeuf, O. / Grisostomi, C. / Boss, C. / Prade, L. / Delahaye, S. / Treiber, A. / Strickner, P. / Binkert, C. / Hess, P. / Steiner, B. / Fischli, W. |
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履歴 | 登録 | 2009年2月9日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2009年6月30日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Non-polymer description / Version format compliance |
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改定 2.0 | 2020年7月29日 | Group: Advisory / Atomic model ...Advisory / Atomic model / Data collection / Database references / Derived calculations / Non-polymer description / Structure summary カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_validate_close_contact / struct_asym / struct_conn / struct_ref_seq_dif / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.formula / _chem_comp.formula_weight / _chem_comp.id / _chem_comp.mon_nstd_flag / _chem_comp.name / _chem_comp.type / _pdbx_nonpoly_scheme.entity_id / _pdbx_nonpoly_scheme.mon_id / _pdbx_nonpoly_scheme.pdb_mon_id / _pdbx_validate_close_contact.auth_atom_id_2 / _pdbx_validate_close_contact.auth_comp_id_2 / _struct_asym.entity_id / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_label_comp_id / _struct_ref_seq_dif.details 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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