登録情報 | データベース: EMDB / ID: EMD-38208 |
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タイトル | Structure of radafaxine-bound state of the human Norepinephrine Transporter |
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マップデータ | |
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試料 | - 複合体: NET
- タンパク質・ペプチド: GFP-MBP-solute carrier family 6 member 2,Maltose/maltodextrin-binding periplasmic protein,Sodium-dependent noradrenaline transporter,Maltose/maltodextrin-binding periplasmic protein,Sodium-dependent noradrenaline transporter
- リガンド: 2-acetamido-2-deoxy-beta-D-glucopyranose
- リガンド: (2~{S},3~{S})-2-(3-chlorophenyl)-3,5,5-trimethyl-morpholin-2-ol
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キーワード | antidepressant / bupropion / TRANSPORT PROTEIN |
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機能・相同性 | 機能・相同性情報
neurotransmitter:sodium symporter activity / Defective SLC6A2 causes orthostatic intolerance (OI) / norepinephrine uptake / norepinephrine:sodium symporter activity / dopamine:sodium symporter activity / norepinephrine transport / neurotransmitter transmembrane transporter activity / monoamine transmembrane transporter activity / Na+/Cl- dependent neurotransmitter transporters / monoamine transport ...neurotransmitter:sodium symporter activity / Defective SLC6A2 causes orthostatic intolerance (OI) / norepinephrine uptake / norepinephrine:sodium symporter activity / dopamine:sodium symporter activity / norepinephrine transport / neurotransmitter transmembrane transporter activity / monoamine transmembrane transporter activity / Na+/Cl- dependent neurotransmitter transporters / monoamine transport / neurotransmitter transport / dopamine uptake involved in synaptic transmission / response to pain / detection of maltose stimulus / amino acid transport / maltose transport complex / neuronal cell body membrane / beta-tubulin binding / carbohydrate transport / carbohydrate transmembrane transporter activity / maltose binding / maltose transport / maltodextrin transmembrane transport / alpha-tubulin binding / sodium ion transmembrane transport / ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing / ATP-binding cassette (ABC) transporter complex / cell chemotaxis / neuron cellular homeostasis / presynaptic membrane / outer membrane-bounded periplasmic space / actin binding / chemical synaptic transmission / periplasmic space / response to xenobiotic stimulus / axon / DNA damage response / cell surface / membrane / metal ion binding / plasma membrane類似検索 - 分子機能 Sodium:neurotransmitter symporter, noradrenaline / Sodium:neurotransmitter symporter family signature 2. / Sodium:neurotransmitter symporter family signature 1. / Sodium:neurotransmitter symporter / Sodium:neurotransmitter symporter superfamily / Sodium:neurotransmitter symporter family / Sodium:neurotransmitter symporter family profile. / Maltose/Cyclodextrin ABC transporter, substrate-binding protein / Solute-binding family 1, conserved site / Bacterial extracellular solute-binding proteins, family 1 signature. ...Sodium:neurotransmitter symporter, noradrenaline / Sodium:neurotransmitter symporter family signature 2. / Sodium:neurotransmitter symporter family signature 1. / Sodium:neurotransmitter symporter / Sodium:neurotransmitter symporter superfamily / Sodium:neurotransmitter symporter family / Sodium:neurotransmitter symporter family profile. / Maltose/Cyclodextrin ABC transporter, substrate-binding protein / Solute-binding family 1, conserved site / Bacterial extracellular solute-binding proteins, family 1 signature. / Bacterial extracellular solute-binding protein / Bacterial extracellular solute-binding protein類似検索 - ドメイン・相同性 Maltose/maltodextrin-binding periplasmic protein / Sodium-dependent noradrenaline transporter類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.04 Å |
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データ登録者 | Wu JX / Ji WM |
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資金援助 | 中国, 1件 Organization | Grant number | 国 |
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National Natural Science Foundation of China (NSFC) | 32371266 | 中国 |
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引用 | ジャーナル: To Be Published タイトル: Substrate binding and inhibition mechanism of norepinephrine transporter 著者: Ji WM / Wu JX |
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履歴 | 登録 | 2023年12月5日 | - |
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ヘッダ(付随情報) 公開 | 2024年7月10日 | - |
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マップ公開 | 2024年7月10日 | - |
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更新 | 2024年7月10日 | - |
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現状 | 2024年7月10日 | 処理サイト: PDBj / 状態: 公開 |
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