登録情報 | データベース: EMDB / ID: EMD-36914 |
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タイトル | Cryo-EM structure of Streptomyces coelicolor transcription initiation complex with the global transcription factor AfsR |
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マップデータ | |
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試料 | - 複合体: Streptomyces coelicolor transcription initiation complex with the global transcription factor AfsR
- タンパク質・ペプチド: DNA-directed RNA polymerase subunit alpha
- タンパク質・ペプチド: DNA-directed RNA polymerase subunit beta
- タンパク質・ペプチド: DNA-directed RNA polymerase subunit beta'
- タンパク質・ペプチド: DNA-directed RNA polymerase subunit omega
- タンパク質・ペプチド: RNA polymerase principal sigma factor HrdB
- DNA: Non-template strand DNA for AfsS promoter
- DNA: Template strand DNA for AfsS promoter
- タンパク質・ペプチド: Regulatory protein AfsR
- リガンド: MAGNESIUM ION
- リガンド: ZINC ION
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キーワード | transcription factor / TRANSCRIPTION-DNA complex / GENE REGULATION |
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機能・相同性 | 機能・相同性情報
pigment binding / bacterial-type RNA polymerase holo enzyme binding / nucleoid / phosphorelay signal transduction system / sigma factor activity / antibiotic biosynthetic process / DNA-directed RNA polymerase complex / DNA-templated transcription initiation / ribonucleoside binding / ADP binding ...pigment binding / bacterial-type RNA polymerase holo enzyme binding / nucleoid / phosphorelay signal transduction system / sigma factor activity / antibiotic biosynthetic process / DNA-directed RNA polymerase complex / DNA-templated transcription initiation / ribonucleoside binding / ADP binding / DNA-directed 5'-3' RNA polymerase activity / DNA-directed RNA polymerase / protein dimerization activity / DNA-templated transcription / regulation of DNA-templated transcription / magnesium ion binding / DNA binding / zinc ion binding / ATP binding / cytoplasm類似検索 - 分子機能 Bacterial transcriptional activator domain / Bacterial transcriptional activator domain / Bacterial transcriptional activator domain / Tetratricopeptide repeat / NB-ARC / NB-ARC domain / OmpR/PhoB-type DNA-binding domain profile. / OmpR/PhoB-type DNA-binding domain / Transcriptional regulatory protein, C terminal / Transcriptional regulatory protein, C terminal ...Bacterial transcriptional activator domain / Bacterial transcriptional activator domain / Bacterial transcriptional activator domain / Tetratricopeptide repeat / NB-ARC / NB-ARC domain / OmpR/PhoB-type DNA-binding domain profile. / OmpR/PhoB-type DNA-binding domain / Transcriptional regulatory protein, C terminal / Transcriptional regulatory protein, C terminal / Tetratricopeptide repeat / Signal transduction response regulator, C-terminal effector / Sigma-70 factors family signature 1. / RNA polymerase sigma factor RpoD, C-terminal / RNA polymerase sigma factor RpoD / RNA polymerase sigma-70 region 1.2 / Sigma-70 factor, region 1.2 / RNA polymerase sigma-70 region 3 / Sigma-70 region 3 / Sigma-70 factors family signature 2. / RNA polymerase sigma-70 / RNA polymerase sigma-70 region 4 / Sigma-70, region 4 / RNA polymerase sigma-70 region 2 / RNA polymerase sigma-70 like domain / Sigma-70 region 2 / RNA polymerase sigma factor, region 2 / RNA polymerase sigma factor, region 3/4-like / DNA-directed RNA polymerase, omega subunit / DNA-directed RNA polymerase, subunit beta-prime, bacterial type / DNA-directed RNA polymerase, beta subunit, external 1 domain superfamily / DNA-directed RNA polymerase, beta subunit, external 1 domain / RNA polymerase beta subunit external 1 domain / RNA polymerase, alpha subunit, C-terminal / Bacterial RNA polymerase, alpha chain C terminal domain / TPR repeat region circular profile. / DNA-directed RNA polymerase, alpha subunit / DNA-directed RNA polymerase beta subunit, bacterial-type / TPR repeat profile. / Tetratricopeptide repeats / Tetratricopeptide repeat / RNA polymerase Rpb6 / RNA polymerase, subunit omega/Rpo6/RPB6 / RNA polymerase Rpb6 / RNA polymerase Rpb1, domain 3 superfamily / RPB6/omega subunit-like superfamily / RNA polymerase Rpb1, clamp domain superfamily / DNA-directed RNA polymerase, subunit beta-prime / RNA polymerase Rpb2, domain 2 superfamily / RNA polymerase Rpb1, domain 3 / RNA polymerase Rpb1, domain 3 / RNA polymerase Rpb1, domain 1 / RNA polymerase Rpb1, domain 1 / RNA polymerase, alpha subunit / RNA polymerase Rpb1, domain 5 / RNA polymerase Rpb1, domain 4 / RNA polymerase Rpb1, domain 2 / RNA polymerase Rpb1, domain 5 / RNA polymerase Rpb1, domain 4 / RNA polymerase, beta subunit, protrusion / RNA polymerase beta subunit / RNA polymerase, N-terminal / RNA polymerase Rpb1, funnel domain superfamily / RNA polymerase I subunit A N-terminus / DNA-directed RNA polymerase, insert domain / DNA-directed RNA polymerase, RpoA/D/Rpb3-type / RNA polymerase Rpb3/RpoA insert domain / RNA polymerase Rpb3/Rpb11 dimerisation domain / RNA polymerases D / DNA-directed RNA polymerase, insert domain superfamily / RNA polymerase, RBP11-like subunit / RNA polymerase Rpb2, domain 2 / RNA polymerase Rpb2, domain 2 / RNA polymerase, beta subunit, conserved site / RNA polymerase Rpb2, domain 7 / RNA polymerase Rpb2, domain 3 / RNA polymerase Rpb2, OB-fold / RNA polymerase Rpb2, domain 7 / RNA polymerase Rpb2, domain 3 / RNA polymerases beta chain signature. / DNA-directed RNA polymerase, subunit 2, hybrid-binding domain / DNA-directed RNA polymerase, subunit 2 / DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily / RNA polymerase Rpb2, domain 6 / Tetratricopeptide-like helical domain superfamily / Winged helix-like DNA-binding domain superfamily / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 RNA polymerase principal sigma factor HrdB / Regulatory protein AfsR / DNA-directed RNA polymerase subunit alpha / DNA-directed RNA polymerase subunit beta' / DNA-directed RNA polymerase subunit omega / DNA-directed RNA polymerase subunit beta類似検索 - 構成要素 |
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生物種 | Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (バクテリア) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.4 Å |
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データ登録者 | Lin W / Shi J / Xu JC |
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資金援助 | 中国, 1件 Organization | Grant number | 国 |
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National Natural Science Foundation of China (NSFC) | 81903526 | 中国 |
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引用 | ジャーナル: Iscience / 年: 2024 タイトル: Structural insights into transcription activation of the Streptomyces antibiotic regulatory protein, AfsR 著者: Shi J / Ye Z / Feng Z / Wen A / Wang L / Zhang Z / Xu L / Song Q / Wang F / Liu T / Wang S / Feng Y / Lin W |
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履歴 | 登録 | 2023年7月24日 | - |
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ヘッダ(付随情報) 公開 | 2024年7月31日 | - |
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マップ公開 | 2024年7月31日 | - |
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更新 | 2024年7月31日 | - |
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現状 | 2024年7月31日 | 処理サイト: PDBc / 状態: 公開 |
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