登録情報 データベース : EMDB / ID : EMD-32334 ダウンロードとリンクタイトル CryoEM structure of human KChIP2-Kv4.3 complex マップデータ 詳細 試料複合体 : Complex of voltage-gated potassium channel Kv4.3 with KChIP2タンパク質・ペプチド : Kv channel-interacting protein 2タンパク質・ペプチド : Isoform 2 of Potassium voltage-gated channel subfamily D member 3 詳細機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
ventricular cardiac muscle cell membrane repolarization / ER retention sequence binding / positive regulation of voltage-gated potassium channel activity / Kv4.2-KChIP2 channel complex / clustering of voltage-gated potassium channels / A-type (transient outward) potassium channel activity / Phase 1 - inactivation of fast Na+ channels / positive regulation of potassium ion export across plasma membrane / potassium channel complex / membrane repolarization during ventricular cardiac muscle cell action potential ... ventricular cardiac muscle cell membrane repolarization / ER retention sequence binding / positive regulation of voltage-gated potassium channel activity / Kv4.2-KChIP2 channel complex / clustering of voltage-gated potassium channels / A-type (transient outward) potassium channel activity / Phase 1 - inactivation of fast Na+ channels / positive regulation of potassium ion export across plasma membrane / potassium channel complex / membrane repolarization during ventricular cardiac muscle cell action potential / membrane repolarization during cardiac muscle cell action potential / potassium ion export across plasma membrane / membrane repolarization / Voltage gated Potassium channels / regulation of potassium ion transmembrane transport / postsynaptic specialization membrane / regulation of heart contraction / 活動電位 / voltage-gated potassium channel activity / potassium channel activity / regulation of heart rate by cardiac conduction / detection of calcium ion / GABA-ergic synapse / potassium channel regulator activity / voltage-gated potassium channel complex / muscle contraction / protein homooligomerization / potassium ion transport / 筋鞘 / chemical synaptic transmission / postsynaptic membrane / transmembrane transporter binding / 樹状突起スパイン / neuronal cell body / シナプス / 樹状突起 / calcium ion binding / protein-containing complex binding / シグナル伝達 / identical protein binding / metal ion binding / 細胞膜 / 細胞質 類似検索 - 分子機能 Potassium channel, voltage dependent, Kv4.3 / Potassium channel, voltage dependent, Kv4 / Shal-type voltage-gated potassium channels, N-terminal / Potassium channel, voltage dependent, Kv4, C-terminal / Shal-type voltage-gated potassium channels, N-terminal / Domain of unknown function (DUF3399) / Recoverin family / Potassium channel, voltage dependent, Kv / Potassium channel tetramerisation-type BTB domain / BTB/POZ domain ... Potassium channel, voltage dependent, Kv4.3 / Potassium channel, voltage dependent, Kv4 / Shal-type voltage-gated potassium channels, N-terminal / Potassium channel, voltage dependent, Kv4, C-terminal / Shal-type voltage-gated potassium channels, N-terminal / Domain of unknown function (DUF3399) / Recoverin family / Potassium channel, voltage dependent, Kv / Potassium channel tetramerisation-type BTB domain / BTB/POZ domain / EF-hand domain pair / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain / Voltage-dependent channel domain superfamily / SKP1/BTB/POZ domain superfamily / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / Ion transport domain / Ion transport protein / EF-hand domain pair 類似検索 - ドメイン・相同性 Kv channel-interacting protein 2 / Potassium voltage-gated channel subfamily D member 3 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度 : 2.8 Å 詳細 データ登録者Ma DM / Guo JT 資金援助 4件 詳細 詳細を隠すOrganization Grant number 国 Ministry of Science and Technology (MoST, China) 2021FZZX001-28 Ministry of Science and Technology (MoST, China) LD21H020001 National Natural Science Foundation of China (NSFC) LR19C050002 National Natural Science Foundation of China (NSFC) LY19H020007
引用ジャーナル : Cell Res / 年 : 2022タイトル : Structural basis for the gating modulation of Kv4.3 by auxiliary subunits.著者 : Demin Ma / Cheng Zhao / Xiaochen Wang / Xiaoxiao Li / Yi Zha / Yan Zhang / Guosheng Fu / Ping Liang / Jiangtao Guo / Dongwu Lai / 履歴 登録 2021年12月2日 - ヘッダ(付随情報) 公開 2022年11月2日 - マップ公開 2022年11月2日 - 更新 2022年11月2日 - 現状 2022年11月2日 処理サイト : PDBj / 状態 : 公開
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