登録情報 | データベース: PDB / ID: 2zdu |
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タイトル | Crystal Structure of human JNK3 complexed with an isoquinolone inhibitor |
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要素 | Mitogen-activated protein kinase 10 |
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キーワード | TRANSFERASE / PROTEIN KINASE / Alternative splicing / ATP-binding / Chromosomal rearrangement / Cytoplasm / Epilepsy / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase |
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機能・相同性 | 機能・相同性情報
JUN kinase activity / Activation of the AP-1 family of transcription factors / Fc-epsilon receptor signaling pathway / MAP kinase kinase activity / response to light stimulus / mitogen-activated protein kinase / JNK cascade / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / regulation of circadian rhythm / FCERI mediated MAPK activation ...JUN kinase activity / Activation of the AP-1 family of transcription factors / Fc-epsilon receptor signaling pathway / MAP kinase kinase activity / response to light stimulus / mitogen-activated protein kinase / JNK cascade / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / regulation of circadian rhythm / FCERI mediated MAPK activation / cellular senescence / rhythmic process / Oxidative Stress Induced Senescence / protein phosphorylation / protein serine kinase activity / signal transduction / mitochondrion / nucleoplasm / ATP binding / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Mitogen-activated protein (MAP) kinase, JNK / : / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 ...Mitogen-activated protein (MAP) kinase, JNK / : / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-446 / Mitogen-activated protein kinase 10類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.5 Å |
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データ登録者 | Sogabe, S. / Ohra, T. / Itoh, F. / Habuka, N. / Fujishima, A. |
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引用 | ジャーナル: Bioorg.Med.Chem. / 年: 2008 タイトル: Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1) 著者: Asano, Y. / Kitamura, S. / Ohra, T. / Aso, K. / Igata, H. / Tamura, T. / Kawamoto, T. / Tanaka, T. / Sogabe, S. / Matsumoto, S. / Yamaguchi, M. / Kimura, H. / Itoh, F. |
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履歴 | 登録 | 2007年11月27日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2008年9月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2023年11月1日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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