登録情報 データベース : PDB / ID : 2qkh 構造の表示 ダウンロードとリンクタイトル Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP 要素Glucose-dependent insulinotropic polypeptide Glucose-dependent insulinotropic polypeptide receptor 詳細キーワード SIGNALING PROTEIN/HORMONE / GPCR / incretin / hormone-GPCR complex / extracellular domain / ligand binding domain / ECD / glugacon receptor family / hormone recognition fold / diabetes / helix formation / Cleavage on pair of basic residues / Polymorphism / Alternative splicing / G-protein coupled receptor / Glycoprotein / Membrane / Transducer / Transmembrane / SIGNALING PROTEIN-HORMONE COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
gastric inhibitory polypeptide receptor binding / gastric inhibitory peptide receptor activity / glucagon family peptide binding / digestive system development / gastric inhibitory peptide signaling pathway / glucagon receptor binding / desensitization of G protein-coupled receptor signaling pathway / regulation of fatty acid biosynthetic process / positive regulation of cAMP-mediated signaling / endocrine pancreas development ... gastric inhibitory polypeptide receptor binding / gastric inhibitory peptide receptor activity / glucagon family peptide binding / digestive system development / gastric inhibitory peptide signaling pathway / glucagon receptor binding / desensitization of G protein-coupled receptor signaling pathway / regulation of fatty acid biosynthetic process / positive regulation of cAMP-mediated signaling / endocrine pancreas development / Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) / response to selenium ion / response to fatty acid / G protein-coupled peptide receptor activity / response to acidic pH / positive regulation of D-glucose transmembrane transport / triglyceride homeostasis / exploration behavior / activation of adenylate cyclase activity / response to lipid / response to starvation / regulation of insulin secretion / peptide hormone binding / response to axon injury / response to amino acid / response to glucose / sensory perception of pain / response to nutrient / adult locomotory behavior / generation of precursor metabolites and energy / female pregnancy / long-term synaptic potentiation / adenylate cyclase-activating G protein-coupled receptor signaling pathway / positive regulation of insulin secretion / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / hormone activity / response to organic cyclic compound / response to peptide hormone / memory / Glucagon-type ligand receptors / response to calcium ion / transmembrane signaling receptor activity / positive regulation of cytosolic calcium ion concentration / G alpha (s) signalling events / secretory granule lumen / cell surface receptor signaling pathway / response to xenobiotic stimulus / endoplasmic reticulum lumen / neuronal cell body / signal transduction / extracellular space / extracellular region / membrane / plasma membrane 類似検索 - 分子機能 Gastric inhibitory polypeptide / GPCR, family 2, gastric inhibitory polypeptide receptor / GPCR, family 2, extracellular hormone receptor domain / Hormone receptor fold / Glucagon/GIP/secretin/VIP / Peptide hormone / Glucagon / GIP / secretin / VIP family signature. / Glucagon like hormones / : / G-protein coupled receptors family 2 signature 1. ... Gastric inhibitory polypeptide / GPCR, family 2, gastric inhibitory polypeptide receptor / GPCR, family 2, extracellular hormone receptor domain / Hormone receptor fold / Glucagon/GIP/secretin/VIP / Peptide hormone / Glucagon / GIP / secretin / VIP family signature. / Glucagon like hormones / : / G-protein coupled receptors family 2 signature 1. / Hormone receptor domain / GPCR, family 2, extracellular hormone receptor domain / G-protein coupled receptors family 2 profile 1. / Domain present in hormone receptors / GPCR family 2, extracellular hormone receptor domain superfamily / G-protein coupled receptors family 2 signature 2. / GPCR, family 2, secretin-like, conserved site / GPCR, family 2, secretin-like / 7 transmembrane receptor (Secretin family) / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2. / Few Secondary Structures / Irregular 類似検索 - ドメイン・相同性 methyl-beta-cyclodextrin / D(-)-TARTARIC ACID / Gastric inhibitory polypeptide / Gastric inhibitory polypeptide receptor 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / 単波長異常分散 / 解像度 : 1.9 Å 詳細データ登録者 Parthier, C. / Kleinschmidt, M. / Neumann, P. / Rudolph, R. / Manhart, S. / Schlenzig, D. / Fanghanel, J. / Rahfeld, J.-U. / Demuth, H.-U. / Stubbs, M.T. 引用ジャーナル : Proc.Natl.Acad.Sci.Usa / 年 : 2007タイトル : Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor著者 : Parthier, C. / Kleinschmidt, M. / Neumann, P. / Rudolph, R. / Manhart, S. / Schlenzig, D. / Fanghanel, J. / Rahfeld, J.-U. / Demuth, H.-U. / Stubbs, M.T. 履歴 登録 2007年7月11日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2007年8月14日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2017年10月18日 Group : Refinement description / カテゴリ : softwareItem : _software.classification / _software.contact_author ... _software.classification / _software.contact_author / _software.contact_author_email / _software.date / _software.language / _software.location / _software.name / _software.type / _software.version 改定 2.0 2020年7月29日 Group : Atomic model / Data collection ... Atomic model / Data collection / Database references / Derived calculations / Non-polymer description / Structure summary カテゴリ : atom_site / atom_site_anisotrop ... atom_site / atom_site_anisotrop / chem_comp / entity / entity_name_com / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_molecule_features / pdbx_nonpoly_scheme / struct_conn / struct_conn_type / struct_ref_seq_dif / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.type_symbol / _atom_site_anisotrop.U[1][1] / _atom_site_anisotrop.U[2][2] / _atom_site_anisotrop.U[3][3] / _atom_site_anisotrop.pdbx_auth_asym_id / _atom_site_anisotrop.pdbx_auth_atom_id / _atom_site_anisotrop.pdbx_auth_comp_id / _atom_site_anisotrop.pdbx_auth_seq_id / _atom_site_anisotrop.pdbx_label_atom_id / _atom_site_anisotrop.pdbx_label_comp_id / _atom_site_anisotrop.type_symbol / _chem_comp.formula / _chem_comp.formula_weight / _chem_comp.id / _chem_comp.mon_nstd_flag / _chem_comp.name / _chem_comp.pdbx_synonyms / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.src_method / _entity.type / _struct_ref_seq_dif.details 解説 : Carbohydrate remediation / Provider : repository / タイプ : Remediation
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