登録情報 | データベース: PDB / ID: 1unl |
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タイトル | Structural mechanism for the inhibition of CD5-p25 from the roscovitine, aloisine and indirubin. |
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要素 | - CYCLIN-DEPENDENT KINASE 5
- CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1
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キーワード | CYCLIN DEPENDENT KINASE / INHIBITOR / ATP-ANALOGUE / NEURODEGENERATIVE DISEASES |
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機能・相同性 | 機能・相同性情報
superior olivary nucleus maturation / protein kinase 5 complex / acetylcholine receptor activator activity / G1 to G0 transition involved in cell differentiation / ErbB-2 class receptor binding / negative regulation of synaptic plasticity / contractile muscle fiber / Activated NTRK2 signals through CDK5 / layer formation in cerebral cortex / neuron cell-cell adhesion ...superior olivary nucleus maturation / protein kinase 5 complex / acetylcholine receptor activator activity / G1 to G0 transition involved in cell differentiation / ErbB-2 class receptor binding / negative regulation of synaptic plasticity / contractile muscle fiber / Activated NTRK2 signals through CDK5 / layer formation in cerebral cortex / neuron cell-cell adhesion / positive regulation of calcium ion-dependent exocytosis / negative regulation of axon extension / receptor catabolic process / regulation of synaptic vesicle cycle / protein localization to synapse / corpus callosum development / regulation of dendritic spine morphogenesis / cerebellar cortex formation / CRMPs in Sema3A signaling / NGF-stimulated transcription / synaptic transmission, dopaminergic / ErbB-3 class receptor binding / calcium ion import / negative regulation of protein export from nucleus / axon extension / cyclin-dependent protein serine/threonine kinase activator activity / regulation of synaptic vesicle recycling / axonal fasciculation / motor neuron axon guidance / dendrite morphogenesis / embryo development ending in birth or egg hatching / regulation of neuron differentiation / synaptic vesicle transport / regulation of cyclin-dependent protein serine/threonine kinase activity / tau-protein kinase activity / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models / beta-tubulin binding / protein kinase activator activity / central nervous system neuron development / oligodendrocyte differentiation / receptor clustering / synaptic vesicle exocytosis / behavioral response to cocaine / synaptic vesicle endocytosis / negative regulation of cell cycle / DARPP-32 events / alpha-tubulin binding / cyclin-dependent protein kinase holoenzyme complex / positive regulation of protein targeting to membrane / ephrin receptor signaling pathway / regulation of protein localization to plasma membrane / regulation of macroautophagy / cyclin-dependent protein serine/threonine kinase activity / Schwann cell development / skeletal muscle tissue development / regulation of synaptic transmission, glutamatergic / regulation of cell migration / sensory perception of pain / positive regulation of microtubule polymerization / negative regulation of protein ubiquitination / synapse assembly / NPAS4 regulates expression of target genes / ionotropic glutamate receptor signaling pathway / excitatory postsynaptic potential / ephrin receptor binding / protein serine/threonine kinase activator activity / cerebellum development / axonogenesis / cell-matrix adhesion / filopodium / synaptic transmission, glutamatergic / hippocampus development / negative regulation of proteolysis / regulation of actin cytoskeleton organization / peptidyl-threonine phosphorylation / axon guidance / intracellular protein transport / ionotropic glutamate receptor binding / neuron migration / Hsp90 protein binding / visual learning / regulation of synaptic plasticity / tau protein binding / neuromuscular junction / neuron differentiation / G protein-coupled acetylcholine receptor signaling pathway / brain development / microtubule cytoskeleton organization / cellular response to amyloid-beta / neuron projection development / actin filament binding / positive regulation of neuron apoptotic process / rhythmic process / p53 binding / presynapse / lamellipodium / cell junction / kinase activity / Factors involved in megakaryocyte development and platelet production / growth cone類似検索 - 分子機能 Cyclin-dependent kinase 5 activator / Cyclin-dependent kinase 5 activator protein / Cyclin-like / Cyclin A; domain 1 / Cyclin-like superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site ...Cyclin-dependent kinase 5 activator / Cyclin-dependent kinase 5 activator protein / Cyclin-like / Cyclin A; domain 1 / Cyclin-like superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 R-ROSCOVITINE / Cyclin-dependent kinase 5 / Cyclin-dependent kinase 5 activator 1類似検索 - 構成要素 |
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生物種 | HOMO SAPIENS (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.2 Å |
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データ登録者 | Mapelli, M. / Crovace, C. / Massimiliano, L. / Musacchio, A. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2005 タイトル: Mechanism of Cdk5/P25 Binding by Cdk Inhibitors 著者: Mapelli, M. / Massimilinao, L. / Crovace, C. / Seeliger, M.A. / Tsai, L.-H. / Meijer, L. / Musacchio, A. |
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履歴 | 登録 | 2003年9月10日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2004年11月10日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Advisory / Version format compliance |
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改定 1.2 | 2023年12月13日 | Group: Data collection / Database references ...Data collection / Database references / Other / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf |
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