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データを開く
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基本情報
登録情報 | データベース: PDB / ID: 1fga | ||||||
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タイトル | REFINEMENT OF THE STRUCTURE OF HUMAN BASIC FIBROBLAST GROWTH FACTOR AT 1.6 ANGSTROMS RESOLUTION AND ANALYSIS OF PRESUMED HEPARIN BINDING SITES BY SELENATE SUBSTITUTION | ||||||
![]() | BASIC FIBROBLAST GROWTH FACTOR | ||||||
![]() | GROWTH FACTOR | ||||||
機能・相同性 | ![]() growth factor dependent regulation of skeletal muscle satellite cell proliferation / positive regulation of inner ear auditory receptor cell differentiation / positive regulation of neuroepithelial cell differentiation / regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / positive regulation of lens fiber cell differentiation / positive regulation of endothelial cell chemotaxis to fibroblast growth factor / positive regulation of cell fate specification / regulation of retinal cell programmed cell death / Formation of intermediate mesoderm / regulation of cell migration involved in sprouting angiogenesis ...growth factor dependent regulation of skeletal muscle satellite cell proliferation / positive regulation of inner ear auditory receptor cell differentiation / positive regulation of neuroepithelial cell differentiation / regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / positive regulation of lens fiber cell differentiation / positive regulation of endothelial cell chemotaxis to fibroblast growth factor / positive regulation of cell fate specification / regulation of retinal cell programmed cell death / Formation of intermediate mesoderm / regulation of cell migration involved in sprouting angiogenesis / FGFRL1 modulation of FGFR1 signaling / corticotropin hormone secreting cell differentiation / thyroid-stimulating hormone-secreting cell differentiation / chondroblast differentiation / lymphatic endothelial cell migration / chemokine binding / negative regulation of fibroblast growth factor receptor signaling pathway / POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation / positive regulation of cerebellar granule cell precursor proliferation / cerebellar granule cell precursor proliferation / positive regulation of stem cell differentiation / Formation of the nephric duct / positive regulation of epithelial tube formation / receptor-receptor interaction / hyaluronan catabolic process / regulation of endothelial cell chemotaxis to fibroblast growth factor / glial cell differentiation / negative regulation of wound healing / inner ear auditory receptor cell differentiation / stem cell development / Signaling by activated point mutants of FGFR3 / FGFR3c ligand binding and activation / Phospholipase C-mediated cascade; FGFR3 / FGFR2b ligand binding and activation / embryonic morphogenesis / fibroblast growth factor receptor binding / angiogenesis involved in coronary vascular morphogenesis / FGFR2c ligand binding and activation / Activated point mutants of FGFR2 / Phospholipase C-mediated cascade; FGFR2 / FGFR4 ligand binding and activation / FGFR1b ligand binding and activation / mammary gland epithelial cell differentiation / Phospholipase C-mediated cascade; FGFR4 / Signaling by activated point mutants of FGFR1 / FGFR1c ligand binding and activation / organ induction / Downstream signaling of activated FGFR1 / Phospholipase C-mediated cascade: FGFR1 / paracrine signaling / negative regulation of fibroblast migration / cell migration involved in sprouting angiogenesis / embryo development ending in birth or egg hatching / endothelial cell proliferation / positive regulation of vascular endothelial cell proliferation / positive regulation of endothelial cell chemotaxis / Signaling by FGFR2 IIIa TM / Syndecan interactions / branching involved in ureteric bud morphogenesis / positive regulation of cell migration involved in sprouting angiogenesis / positive regulation of DNA biosynthetic process / positive regulation of neuroblast proliferation / PI-3K cascade:FGFR3 / PI-3K cascade:FGFR2 / positive regulation of sprouting angiogenesis / positive regulation of stem cell proliferation / PI-3K cascade:FGFR4 / chemoattractant activity / PI-3K cascade:FGFR1 / negative regulation of blood vessel endothelial cell migration / positive regulation of cell division / Non-integrin membrane-ECM interactions / PI3K Cascade / neuroblast proliferation / response to axon injury / positive regulation of blood vessel endothelial cell migration / fibroblast growth factor receptor signaling pathway / canonical Wnt signaling pathway / regulation of angiogenesis / positive regulation of osteoblast differentiation / SHC-mediated cascade:FGFR3 / SHC-mediated cascade:FGFR2 / SHC-mediated cascade:FGFR4 / SHC-mediated cascade:FGFR1 / negative regulation of stem cell proliferation / release of sequestered calcium ion into cytosol / FRS-mediated FGFR3 signaling / positive regulation of cardiac muscle cell proliferation / FRS-mediated FGFR2 signaling / FRS-mediated FGFR4 signaling / Signaling by FGFR3 in disease / FRS-mediated FGFR1 signaling / positive regulation of vascular associated smooth muscle cell proliferation / positive regulation of endothelial cell proliferation / Signaling by FGFR2 in disease / substantia nigra development / ERK1 and ERK2 cascade / Signaling by FGFR1 in disease / positive regulation of endothelial cell migration / phosphatidylinositol 3-kinase/protein kinase B signal transduction 類似検索 - 分子機能 | ||||||
生物種 | ![]() | ||||||
手法 | ![]() | ||||||
![]() | Eriksson, A.E. / Matthews, B.W. | ||||||
![]() | ![]() タイトル: Refinement of the structure of human basic fibroblast growth factor at 1.6 A resolution and analysis of presumed heparin binding sites by selenate substitution. 著者: Eriksson, A.E. / Cousens, L.S. / Matthews, B.W. #1: ![]() タイトル: Three-Dimensional Structure of Human Basic Fibroblast Growth Factor 著者: Eriksson, A.E. / Cousens, L.S. / Weaver, L.H. / Matthews, B.W. | ||||||
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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ダウンロードとリンク
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ダウンロード
PDBx/mmCIF形式 | ![]() | 35.2 KB | 表示 | ![]() |
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PDB形式 | ![]() | 26.3 KB | 表示 | ![]() |
PDBx/mmJSON形式 | ![]() | ツリー表示 | ![]() | |
その他 | ![]() |
-検証レポート
文書・要旨 | ![]() | 440.2 KB | 表示 | ![]() |
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文書・詳細版 | ![]() | 450 KB | 表示 | |
XML形式データ | ![]() | 9.5 KB | 表示 | |
CIF形式データ | ![]() | 12.1 KB | 表示 | |
アーカイブディレクトリ | ![]() ![]() | HTTPS FTP |
-関連構造データ
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リンク
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集合体
登録構造単位 | ![]()
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単位格子 |
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Atom site foot note | 1: SG SEO 69 IS BONDED TO SG CYS 69 AND SG SEO 92 IS BONDED TO SD CYS 92. |
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要素
#1: タンパク質 | 分子量: 16435.857 Da / 分子数: 1 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() | ||||
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#2: 化合物 | #3: 化合物 | #4: 水 | ChemComp-HOH / | |
-実験情報
-実験
実験 | 手法: ![]() |
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試料調製
結晶 | マシュー密度: 1.82 Å3/Da / 溶媒含有率: 32.48 % | ||||||||||||||||||||||||||||||
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結晶化 | *PLUS pH: 8.1 / 手法: 蒸気拡散法 / 詳細: using macroseeding | ||||||||||||||||||||||||||||||
溶液の組成 | *PLUS
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-データ収集
回折 | Ambient pressure: 101 kPa / 平均測定温度: 298 K |
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放射光源 | 由来: rotating-anode X-ray tube / タイプ: RIGAKU RU200 / Target: Cu |
検出器 | タイプ: AREA DETECTOR / 検出器: AREA DETECTOR / 詳細: Xuong-Hamlin |
放射 | モノクロメーター: graphite / プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray / 波長: 1.5418 Å |
放射波長 | 相対比: 1 |
反射 | *PLUS 最高解像度: 1.6 Å / 最低解像度: 2.2 Å / Num. all: 46606 / Num. obs: 13971 / Rmerge(I) obs: 0.04 |
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解析
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精密化 | 解像度: 2.2→20 Å / Rfactor obs: 0.138 | ||||||||||||
精密化ステップ | サイクル: LAST / 解像度: 2.2→20 Å
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拘束条件 |
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精密化 | *PLUS 最高解像度: 2.2 Å / 最低解像度: 20 Å / Rfactor obs: 0.138 | ||||||||||||
溶媒の処理 | *PLUS | ||||||||||||
原子変位パラメータ | *PLUS | ||||||||||||
拘束条件 | *PLUS
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