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TitleHuman enterotoxigenic Escherichia coli (ETEC) infections elicit antibodies that broadly neutralize mucinases of pathogenic Escherichia coli and Shigella.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 123, Page e2614012123-e2614012123, Year 2026
Publish dateNov 16, 2025 (structure data deposition date)
AuthorsBuckley, D.P. / Akhtar, M. / Thapa, M. / Schmitz, A. / Turner, J. / Vickers, T.J. / Khatoon, N. / Kaisar, M.H. / Coggin, J.A. / Ganguli, D. ...Buckley, D.P. / Akhtar, M. / Thapa, M. / Schmitz, A. / Turner, J. / Vickers, T.J. / Khatoon, N. / Kaisar, M.H. / Coggin, J.A. / Ganguli, D. / Sheikh, A. / Laird, R.M. / Poly, F. / Porter, C.K. / Ruiz-Perez, F. / Miller, M.J. / Chowdhury, F. / Bhuiyan, T.R. / Qadri, F. / Trillo-Muyo, S. / Dolan, B. / van der Post, S. / Ellebedy, A. / Berndsen, Z.T. / Fleckenstein, J.M.
External linksProc. Natl. Acad. Sci. USA / PubMed:42296351
MethodsEM (single particle)
Resolution1.99 - 3.7 Å
Structure data

PDB-9z76:
Cryo-EM structure of Enterotoxigenic Escherichia coli autotransporter A (EatA) complexed with the fragment antigen binding domain of monoclonal antibody 25
Method: ELECTRON MICROSCOPY / Resolution: 3.32 Å

PDB-9z77:
Cryo-EM structure of Enterotoxigenic Escherichia coli autotransporter A (EatA) complexed with the fragment antigen binding domain of monoclonal antibody G12
Method: ELECTRON MICROSCOPY / Resolution: 3.7 Å

PDB-9z78:
Cryo-EM structure of Enterotoxigenic Escherichia coli autotransporter A (EatA) complexed with the fragment antigen binding domain of monoclonal antibody 15
Method: ELECTRON MICROSCOPY / Resolution: 2.64 Å

PDB-9z79:
Cryo-EM structure of Enterotoxigenic Escherichia coli autotransporter A (EatA) complexed with the fragment antigen binding domain of monoclonal antibody 40
Method: ELECTRON MICROSCOPY / Resolution: 2.66 Å

PDB-9z7a:
Cryo-EM structure of Secreted extracellular protein A (SepA) from Shigella flexneri complexed with the fragment antigen binding domain of monoclonal antibody 40
Method: ELECTRON MICROSCOPY / Resolution: 1.99 Å

PDB-9z7b:
Cryo-EM structure of Protein involved in colonization (Pic) from Enteroaggregative Escherichia coli complexed with the fragment antigen binding domain of monoclonal antibody 40
Method: ELECTRON MICROSCOPY / Resolution: 2.69 Å

Source
  • escherichia coli (E. coli)
  • homo sapiens (human)
  • shigella flexneri 2a str. 2457t (bacteria)
  • escherichia coli 042 (bacteria)
KeywordsHYDROLASE/IMMUNE SYSTEM / PROTEASE / BETA-HELIX / SECRETED / MONOCLONAL ANTIBODY / HYDROLASE / HYDROLASE-IMMUNE SYSTEM complex

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