Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	The structural basis for LRRK2's activation and autoinhibition
Journal, issue, pages	Cell(Cambridge,Mass. ), Year 2026
Publish date	Sep 9, 2025 (structure data deposition date)
Authors	Villagran Suarez A / Hatch KS / Bodrug T / Gai W / Surridge KJ / Moussikhina E / Nguyen KH / Sanz-Murillo M / Callahan R / Xiong E ...Villagran Suarez A / Hatch KS / Bodrug T / Gai W / Surridge KJ / Moussikhina E / Nguyen KH / Sanz-Murillo M / Callahan R / Xiong E / Ramos D / Zhu L / Dederer V / Mathea S / Iwasa J / Knapp S / Shokat KM / Reck-Peterson SL / Leschziner AE
External links	Cell(Cambridge,Mass. ) / Search PubMed
Methods	EM (single particle)
Resolution	3.0 - 4.39 Å
Structure data	72649 9y7a EMDB-72649, PDB-9y7a: Leucine Rich Repeat Kinase 2 bound to GMP-PNP (inactive) Method: EM (single particle) / Resolution: 4.39 Å 72656 9y7i EMDB-72656, PDB-9y7i: Leucine Rich Repeat Kinase 2 bound to GMP-PNP (active) Method: EM (single particle) / Resolution: 3.73 Å 72751 9ybl EMDB-72751, PDB-9ybl: LRRK2 asymmetric dimer Method: EM (single particle) / Resolution: 3.44 Å 72756 9ybp EMDB-72756, PDB-9ybp: Leucine Rich Repeat Kinase 2 activate state (Apo ROC state 2) Method: EM (single particle) / Resolution: 4.0 Å 72762 9yc8 EMDB-72762, PDB-9yc8: Leucine Rich Repeat Kinase 2 activate state (Apo ROC state 1) Method: EM (single particle) / Resolution: 4.02 Å 72768 9ycd EMDB-72768, PDB-9ycd: Leucine Rich Repeat Kinase 2 R1441C mutant (active) Method: EM (single particle) / Resolution: 3.63 Å EMDB-72940: LRRK2 activated (flexible C-terminus) Method: EM (single particle) / Resolution: 3.53 Å 72941 9ygt EMDB-72941, PDB-9ygt: Leucine Rich Repeat Kinase 2 bound to GDP (from GMPPNP data) Method: EM (single particle) / Resolution: 3.42 Å EMDB-72978: Leucine Rich Repeat LRRK2 (GDP data) Method: EM (single particle) / Resolution: 4.14 Å EMDB-72982: Leucine Rich Repeat Kinase 2 active state (Apo state 3) Method: EM (single particle) / Resolution: 3.72 Å EMDB-73484: Focused refinement map on N-terminal half of LRRK2 GMPPNP (active)-Resolved EM Method: EM (single particle) / Resolution: 3.73 Å EMDB-73485: Focused refinement map on N-terminal half of LRRK2 bound to GMPPNP (active) Method: EM (single particle) / Resolution: 3.76 Å EMDB-73487: LRRK2 bound to GMP-PNP (inactive) Method: EM (single particle) / Resolution: 4.39 Å EMDB-73491: Focused refinement map on LRRK2 bound to GMPPNP (inactive) Method: EM (single particle) / Resolution: 4.35 Å EMDB-73492: Focused refinement map on LRRK2 bound to GMPPNP (inactive) Resolve EM Method: EM (single particle) / Resolution: 4.35 Å EMDB-73495: Focused refinement map of LRRK2 APO state 2 Method: EM (single particle) / Resolution: 3.82 Å EMDB-73496: Focused refinement map of LRRK2 APO state 1 Method: EM (single particle) / Resolution: 4.01 Å EMDB-73497: Focused map of LRRK2 bound to G10 (top) Method: EM (single particle) / Resolution: 3.0 Å EMDB-73499: Focused map of LRRK2 bound to G10 (WD40-DARPin) Method: EM (single particle) / Resolution: 3.21 Å EMDB-73501: Focused map of LRRK2 R1441C (active) Method: EM (single particle) / Resolution: 3.61 Å EMDB-73502: Focused map of LRRK2 R1441C (active) ResolveEM Method: EM (single particle) / Resolution: 3.61 Å
Chemicals	ChemComp-GNP: PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogueYM ChemComp-A1N: (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine ChemComp-GDP: GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying moleculeYM ChemComp-MG: Unknown entry
Source	homo sapiens (human)
Keywords	HYDROLASE / Kinase / GTPases / LRRK2 / GTPase