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TitleDistinctive molecular architectures of G- and G-coupled GLP-1 receptors.
Journal, issue, pagesActa Pharm Sin B, Vol. 16, Issue 3, Page 1779-1785, Year 2026
Publish dateJan 23, 2026
AuthorsQingtong Zhou / Jie Li / Yao Zhang / Xiaoqing Cai / Wei Han / Dehua Yang / Ming-Wei Wang /
External linksActa Pharm Sin B / PubMed:41909725 / PubMed Central
MethodsEM (single particle)
Resolution2.92 - 3.18 Å
Structure data

66468

9x20

EMDB-66468, PDB-9x20:
Cryo-EM structure of the GLP-1-bound human GLP-1R-Gi complex
Method: EM (single particle) / Resolution: 3.18 Å

66470

9x22

EMDB-66470, PDB-9x22:
Cryo-EM structure of the GLP-1-bound human GLP-1R-Gq complex
Method: EM (single particle) / Resolution: 2.92 Å

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsSIGNALING PROTEIN/IMMUNE SYSTEM / GLP-1R / SIGNALING PROTEIN-IMMUNE SYSTEM complex

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