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TitleMechanistic insight into signal bias by the agonist-dependent conformational dynamics of GPR84
Journal, issue, pagesTo Be Published
Publish dateAug 28, 2025 (structure data deposition date)
AuthorsSuzuki, S. / Nishikawa, K. / Tran, D.P. / Akio, K. / Fujiyoshi, Y.
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.05 - 3.3 Å
Structure data

PDB-9wij:
Cryo-EM structure of GPR84 with GLPG1205
Method: ELECTRON MICROSCOPY / Resolution: 3.05 Å

PDB-9wik:
Cryo-EM structure of GPR84-Gi complex with DL-175
Method: ELECTRON MICROSCOPY / Resolution: 3.3 Å

Chemicals

PDB-1l93:
SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES


PDB Unreleased entry

PDB-1mbr: Unknown entry

Source
  • homo sapiens (human)
  • escherichia coli (E. coli)
  • synthetic construct (others)
KeywordsMEMBRANE PROTEIN / GPCR / SIGNALING PROTEIN

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