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TitleDual agonism and selective T-cell depletion activity of a PD-1-directed antibody for treating autoimmune diseases.
Journal, issue, pagesMabs, Vol. 18, Page 2624881-2624881, Year 2026
Publish dateJul 30, 2025 (structure data deposition date)
AuthorsJiang, W. / Li, L. / Xue, W. / He, X. / Chu, X. / Song, L. / Li, X. / Zhao, R. / Yuan, X. / Jin, X. ...Jiang, W. / Li, L. / Xue, W. / He, X. / Chu, X. / Song, L. / Li, X. / Zhao, R. / Yuan, X. / Jin, X. / Fan, L. / Sun, T. / Zhu, A. / Zhou, L. / Gu, F. / Xu, Q. / Ma, G. / Wang, S. / Jin, L. / Xu, J.L.
External linksMabs / PubMed:41640111
MethodsEM (single particle)
Resolution2.96 Å
Structure data

PDB-9w43:
Structure of the complex of human PD-1 and a PD-1-directed antibody
Method: ELECTRON MICROSCOPY / Resolution: 2.96 Å

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / PD-1 / PD-1-directed antibody / antigen-antibody complex

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