| Title | Mechanistic basis for activation and selectivity of NK2R by endogenous and synthetic peptide agonists |
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| Journal, issue, pages | To Be Published |
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| Publish date | Jul 25, 2025 (structure data deposition date) |
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Authors | Ren Y / Pavlovskyil A / Liu X / Gerhart-Hines Z |
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External links | Search PubMed |
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| Methods | EM (single particle) |
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| Resolution | 2.82 - 3.4 Å |
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| Structure data | EMDB-65549, PDB-9w1j: Cryo-EM structure of neurokinin A (NKA)-bound neurokinin 2 receptor (NK2R) in complex with miniGs/q70 Method: EM (single particle) / Resolution: 2.97 Å EMDB-65570, PDB-9w2g: Cryo-EM structure of EB1001-bound neurokinin 2 receptor (NK2R) in complex with miniGs/q70 Method: EM (single particle) / Resolution: 3.4 Å EMDB-65571, PDB-9w2h: Cryo-EM structure of EB1002-bound neurokinin 2 receptor (NK2R) in complex with miniGs/q70 Method: EM (single particle) / Resolution: 3.12 Å EMDB-65572, PDB-9w2i: Cryo-EM structure of Peptide 336 (P336)-bound neurokinin 2 receptor (NK2R) in complex with miniGs/q70 Method: EM (single particle) / Resolution: 2.93 Å EMDB-65573, PDB-9w2j: Cryo-EM structure of Peptide 383 (P383)-bound neurokinin 2 receptor (NK2R) in complex with miniGs/q70 Method: EM (single particle) / Resolution: 2.82 Å |
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| Source | homo sapiens (human) lama glama (llama)- synthetic construct (others)
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Keywords | MEMBRANE PROTEIN / GPCR / Neurokinin A (NKA) / Neurokinin 2 Receptor (NK2R) / Active State / EB1001 / EB1002 / Peptide 336 (P336) / Peptide 383 (P383) |
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