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Structure paper

TitleElectric dipole moment drives the dynamics of the TNFR1 complex I signalosome
Journal, issue, pagesNature, Year 2026
Publish dateMay 30, 2025 (structure data deposition date)
AuthorsZhao K / Liu JP / Liu C / Yuan JY
External linksNature / Search PubMed
MethodsEM (helical sym.) / EM (single particle)
Resolution2.62 - 3.41 Å
Structure data

64869

9v9c

EMDB-64869, PDB-9v9c:
Cryo-EM structure of human TNFR1 DD filament
Method: EM (helical sym.) / Resolution: 2.62 Å

64870

9v9e

EMDB-64870, PDB-9v9e:
Cryo-EM structure of human RIPK1 DD filament
Method: EM (helical sym.) / Resolution: 2.87 Å

65047

9vgd

EMDB-65047, PDB-9vgd:
Helical assembly of TRADD death domain
Method: EM (helical sym.) / Resolution: 3.3 Å

65094

9vin

EMDB-65094, PDB-9vin:
Ternary complex of TNFR1-DD, TRADD-DD and RIPK1-DD
Method: EM (single particle) / Resolution: 3.41 Å

Source
  • homo sapiens (human)
KeywordsPROTEIN FIBRIL / Death doamin / APOPTOSIS / Death domain / Inflammation / Tumor necrosis factor / TNFR1 / RIPK1 / TRADD

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