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TitleDistinct filament morphology and membrane tethering features of the dual FtsZ paralogs in Odinarchaeota.
Journal, issue, pagesEMBO J, Vol. 44, Issue 21, Page 5940-5964, Year 2025
Publish dateAug 8, 2025
AuthorsJayanti Kumari / Akhilesh Uthaman / Sucharita Bose / Ananya Kundu / Vaibhav Sharma / Soumyajit Dutta / Anubhav Dhar / Srijita Roy / Ramanujam Srinivasan / Samay Pande / Kutti R Vinothkumar / Pananghat Gayathri / Saravanan Palani /
PubMed AbstractThe Asgard phylum has emerged as a model to study eukaryogenesis because of their close relatedness with the eukaryotes. In this study, we use FtsZ proteins from a member of the class Odinarchaeia as ...The Asgard phylum has emerged as a model to study eukaryogenesis because of their close relatedness with the eukaryotes. In this study, we use FtsZ proteins from a member of the class Odinarchaeia as representatives to investigate the probable origin, evolution, and assembly of the FtsZ/tubulin protein superfamily in Asgard archaea. We performed a comparative analysis of the biochemical properties and cytoskeletal assembly of FtsZ1 and FtsZ2, the two FtsZ isoforms in the Odinarchaeota metagenome. Our electron microscopy analysis reveals that OdinFtsZ1 assembles into curved single protofilaments, while OdinFtsZ2 forms stacked spiral ring-like structures. Upon sequence analysis, we identified an N-terminal amphipathic helix in OdinFtsZ1, which mediates direct membrane tethering. In contrast, OdinFtsZ2 is recruited to the membrane by the anchor OdinSepF via OdinFtsZ2's C-terminal tail. Overall, we report the presence of two distant evolutionary paralogs of FtsZ in Odinarchaeota, with distinct filament assemblies and differing modes of membrane targeting. Our findings highlight the diversity of FtsZ proteins in the archaeal phylum Asgardarchaeota, providing valuable insights into the evolution and differentiation of tubulin-family proteins.
External linksEMBO J / PubMed:40781499 / PubMed Central
MethodsEM (helical sym.)
Resolution3.6 Å
Structure data

64825

9v7v

EMDB-64825, PDB-9v7v:
Structure of FtsZ1 in complex with GMPCPP from Candidatus Odinarchaeota
Method: EM (helical sym.) / Resolution: 3.6 Å

Chemicals

ChemComp-G2P:
PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER / GMP-CPP, energy-carrying molecule analogue*YM

Source
  • candidatus odinarchaeota (archaea)
KeywordsCELL CYCLE / Cell division Protein

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