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TitleMolecular mechanisms of naturally encoded signaling bias at the complement anaphylatoxin receptors.
Journal, issue, pagesMol. Cell, Year 2026
Publish dateApr 6, 2026 (structure data deposition date)
AuthorsTiwari, D. / Sawada, K. / Dalal, A. / Mishra, S. / Li, X.X. / Dent, J.C. / Kim, K. / Yadav, M.K. / Roy, N. / Ganguly, M. ...Tiwari, D. / Sawada, K. / Dalal, A. / Mishra, S. / Li, X.X. / Dent, J.C. / Kim, K. / Yadav, M.K. / Roy, N. / Ganguly, M. / Banerjee, N. / Stepniewski, T.M. / Ahn, D. / Yamaguchi, K. / Oshima, H.S. / Hashimoto, K. / Fung, J.N. / Lerskiatiphanich, T. / Cui, C.S. / Lee, J.D. / Selent, J. / Inoue, A. / Clark, R.J. / Chung, K.Y. / Banerjee, R. / Sano, F.K. / Woodruff, T.M. / Nureki, O. / Shukla, A.K.
External linksMol. Cell / PubMed:42330960
MethodsEM (single particle)
Resolution2.97 - 3.82 Å
Structure data

PDB-25if:
Structure of mC5aR2 in complex with mC5a-desArg (Monomer)
Method: ELECTRON MICROSCOPY / Resolution: 3.42 Å

PDB-9v35:
Structure of C5a anaphylatoxin chemotactic receptor 2, C5aR2 in the Apo state
Method: ELECTRON MICROSCOPY / Resolution: 2.97 Å

PDB-9v38:
Structure of C5a anaphylatoxin chemotactic receptor 2, C5aR2 bound to EP54
Method: ELECTRON MICROSCOPY / Resolution: 3.25 Å

PDB-9v3c:
Structure of C5a anaphylatoxin chemotactic receptor 2, C5aR2 bound to C5a
Method: ELECTRON MICROSCOPY / Resolution: 3.82 Å

PDB-9v3y:
Structure of C5a anaphylatoxin chemotactic receptor 2, C5aR2 bound to C5a-pep
Method: ELECTRON MICROSCOPY / Resolution: 3.06 Å

PDB-9v4d:
Structure of C5a anaphylatoxin chemotactic receptor 2, C5aR2 bound to R8Y
Method: ELECTRON MICROSCOPY / Resolution: 3.07 Å

PDB-9wdi:
Structure of mC5aR2 in complex with mC5a-desArg
Method: ELECTRON MICROSCOPY / Resolution: 3.33 Å

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / G protein coupled receptor / G protein / Membrane protein / Immunite system

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