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-Structure paper
| タイトル | Virological characteristics of SARS-CoV-2-related coronaviruses dynamically circulating in Southeast Asia. |
|---|---|
| ジャーナル・号・ページ | Cell, Vol. 189, Issue 13, Page 4075-4093.e25, Year 2026 |
| 掲載日 | 2026年6月25日 |
著者 | Supaporn Wacharapluesadee / Wilaiporn Saikruang / Spyros Lytras / Kanata Matsumoto / Keiya Uriu / Alfredo Hinay / Ziyi Guo / Khwankamon Rattanatumhi / Ananporn Supataragul / Sasiprapa Ninwattana / Nattakarn Thippamom / Tanawut Srisuk / Patarapol Maneeorn / Kirana Noradechanon / Prateep Duengkae / Nutthinee Sirichan / Yusuke Kosugi / Shigeru Fujita / Maximilian Stanley Yo / Ryo Matsunaga / Bingjie Hu / Lianzhao Du / Lei Wang / Masumi Tsuda / Yoshitaka Oda / Hesham Nasser / Kanako Terakado Kimura / Hiroaki Akasaka / Hiroyuki Asakura / Mami Nagashima / Kenji Sadamasu / Kazuhisa Yoshimura / Yuki Yamamoto / Tetsuharu Nagamoto / Takanori Asakura / Wataru Shihoya / Takao Hashiguchi / Terumasa Ikeda / Shinya Tanaka / Hin Chu / Kouhei Tsumoto / Osamu Nureki / / / Arnon Plianchaisuk / Opass Putcharoen / Kei Sato / ![]() |
| PubMed 要旨 | By sampling horseshoe bats-the reservoir hosts of SARS-CoV-2-related coronaviruses (SC2r-CoVs)-in Thailand, we present two clades of SC2r-CoVs co-circulating in the same bat population. Through a ...By sampling horseshoe bats-the reservoir hosts of SARS-CoV-2-related coronaviruses (SC2r-CoVs)-in Thailand, we present two clades of SC2r-CoVs co-circulating in the same bat population. Through a comprehensive set of experimental approaches, including cryo-electron microscopy (cryo-EM), pseudovirus and live virus assays, and hamster experiments, we characterize the virological properties of these new viruses. We show that one of the two clades discovered in this study is able to bind the human angiotensin converting enzyme 2 (ACE2) receptor; however, it exhibits reduced fusogenicity and replication in vitro and lower pathogenicity and transmissibility compared with SARS-CoV-2. Phylogeography and recombination analyses reveal a complex evolutionary history for these viruses characterized by extensive, recent geographic movement and recombination with co-circulating virus lineages. Our findings provide new insights into the diversity of SC2r-CoVs dynamically co-circulating in Southeast Asia as well as the virological characteristics of these viruses relative to SARS-CoV-2. |
リンク | Cell / PubMed:42097139 |
| 手法 | EM (単粒子) |
| 解像度 | 2.77 Å |
| 構造データ | EMDB-63852, PDB-9u4o: |
| 化合物 | ![]() ChemComp-NAG: |
| 由来 |
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キーワード | VIRAL PROTEIN / COMPLEX |
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万見文献について



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リンク


coronaviridae (ウイルス)
homo sapiens (ヒト)
キーワード